Patchouli alcohol: In vitro direct anti-influenza virus sesquiterpene in Pogostemon cablin Benth.

Journal of Natural Medicines

Volumn 66, Issue 1, 2012, Pages 55-61

  Kiyohara, Hiroaki ^a   Ichino, Chikara ^a   Kawamura, Yuka ^a   Nagai, Takayuki ^a   Sato, Noriko ^a   Yamada, Haruki ^a  

^a KITASATO UNIVERSITY   (Japan)

Author keywords

Influenza virus; Lamiaceae (Labiatae); Patchouli alcohol; Pogostemon cablin Benth.

Indexed keywords

ANTIVIRUS AGENT; BISABOLENE; CADINENE; CARYOPHYLLENE; CEDRENE; CEDROL; DIHYDROFARNESOL; ELEMOL; FARNESOL; HEXANE; METHANOL; NOOTKATONE; PATCHOULI ALCOHOL; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; POGOSTEMON CABLIN EXTRACT; SESQUITERPENE DERIVATIVE; SILICA GEL; THUJOPSENE; UNCLASSIFIED DRUG; VALENCENE; VIRUS SIALIDASE;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; COLUMN CHROMATOGRAPHY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; FRACTIONATION; IC 50; IN VITRO STUDY; INFLUENZA VIRUS A H1N1; INFLUENZA VIRUS A H3N2; INFLUENZA VIRUS B; KIDNEY CELL; MEDICINAL PLANT; NONHUMAN; PLAQUE FORMING CELL; POGOSTEMON CABLIN; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SOLVENT FRACTIONATION; VIRUS CELL INTERACTION; VIRUS LOAD;

ANIMALS; ANTIVIRAL AGENTS; CELL LINE; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, REVERSE-PHASE; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEXANES; INFLUENZA A VIRUS, H1N1 SUBTYPE; LAMIACEAE; NEURAMINIDASE; PLANT EXTRACTS; PLANT LEAVES; PLANTS, MEDICINAL; SESQUITERPENES; SOLVENTS; VIRAL PLAQUE ASSAY; VIRAL PROTEINS;

EID: 84856228937     PISSN: 13403443     EISSN: 18610293     Source Type: Journal    
DOI: 10.1007/s11418-011-0550-x     Document Type: Article

References (25)

1. Long JK, Mossak SB, Goldman MP (1999) Antiviral agents for treating influenza. Cleve Clin J Med 67:92-95 (Pubitemid 30091205)
2. Hirsch MS, Kaplan JC (1990) Antiviral agents. In: Fields BN, Knipe DM (eds) Virology. Raven, New York, pp 441-468
3. Stephenson I, Nicholson KG (1999) Chemotherapeutic control of influenza. J Antimicrob Chemother 44:6-10 (Pubitemid 29353676)
4. Ge H, Wang YF, Xu J, Gu Q, Liu HB, Xiao PG, Zhou J, Liu Y, Yang Z, Su H (2010) Anti-influenza agents from traditional Chinese medicine. Nat Prod Rep 27:1758-1780
5. Pappaioanou M (2009) Highly pathogenic H5N1 avian influenza virus: cause of the next pandemic? Comp Immunol Microbiol Infect Dis 32:287-300
6. Girard MP, Tam JS, Assossou OM, Kieny MP (2010) The 2009 A (H1N1) influenza virus pandemic: a review. Vaccine 28:4895-4902
7. Boltz DA, Aldridge JR Jr, Webster RG, Govorkova EA (2010) Drugs in development for influenza. Drugs 70:1349-1362
8. Kawamura Y, Kiyohara H, Nagai T, Hiramoto T, Yamada H (2010) Anti-influenza virus active sesquiterpene from leaves of Pogostemon cablin. Abstr Annu Meet Pharm Soc Jpn 130(2):179
9. Xie YC, Tang F (2009) Protective effect of Pogostemon cablin on membrane fluidity of intestinal epithelia cell in ischemia/reperfusion rats after ischemia/reperfusion. Zhongguo Zhong Xi Yi Jie He Za Zhi 29:639-641
10. Kim HW, Cho SJ, Kim BY, Cho SI, Kim YK (2010) Pogostemon cablin as ROS scavenger in oxidant-induced cell death of human neuroglioma cells. Evid Based Complement Alternat Med 7:239-247. doi:10.1093/ecam/nem176
11. Tsai YC, Hsu HC, Yang WC, Tsai WJ, Chen CC, Watanabe T (2007) a-Bulnesene, a PAF inhibitor isolated from the essential oil of Pogostemon cablin. Fitoterapia 78:7-11 (Pubitemid 44909359)
12. Yang Y, Kinoshita K, Koyama K, Takahashi K, Tai T, Nunoura Y, Watanabe K (1999) Anti-emetic principles of Pogostemon cablin (Blanco) Benth. Phytomedicine 6:89-93 (Pubitemid 129634465)
13. Lai X, Su Z, Zhang F, Peng S, Hu J (2010) Use of patchouli alcohol in medicament preparation. PCT WO2010/096987
14. Shimizu T, Hino A, Tsutsumi A, Park YK, Watanabe W, Kurokawa M (2008) Anti-influenza virus activity of propolis in vitro and its efficacy against influenza infection in mice. Antivir Chem Chemother 19:7-13
15. Neszmelyi A, Lukacs G (1981) Natural abundance 13C-13C coupling constants for carbon connectivity pattern determination and NMR spectra analysis: patchoulol. J Chem Soc Chem Commun 999-1001
16. Dobler M, Dunitz JD, Gubler B, Weber HP (1963) The structure of patchouli alcohol. Proc Chem Soc London 383
17. Roberts JS (1972) The sesquiterpenoids. In: Newman AA (ed) Chemistry of terpenes and terpenoids. Academic, London, pp 88-146
18. Wei G (2007) Digitalization of gas chromatography-mass spectrometry characteristic fingerprint chromatogram of Pogostemon cablin and its application in herb identification. Zhongchengyao 29:322-325
19. Cai QQ, Huang YH, Xi P, Zen HF, Tang HM (2006) Analysis of Huoxiangzhengqifang extracted by supercritical carbon dioxide with TLC and gas chromatography-mass spectrometry. Xiandai Shipin Yu Yaopin Zazhi 16:32-34
20. Minagawa K, Kouzuki S, Yoshimoto J, Kawamura Y, Tani H, Iwata T, Terui Y, Nakai H, Yagi S, Hattori N, Fujiwara T, Kamigauchi T (2002) Stachyflin and acetylstachyflin, novel antiinfluenza A virus substances, produced by Stachybotrys sp. RF-7260 J Antibiotics 55:155-164
21. Wright AE, Rueth SA, Cross SS (1991) An antiviral sesquiterpene hydroquinone from the marine sponge Strongylophora hartmani. J Nat Prod 54:1108-1111
22. Yoshimoto J, Kakui M, Iwasaki H, Fujiwara T, Sugimoto H, Hattori N (1999) Identification of a novel HA conformational change inhibitor of human influenza virus. Arch Virol 144:865-878 (Pubitemid 29284852)
23. Nagai T, Nishibe Y, Makino Y, Tomimori T, Yamada H (1997) Enhancement of in vivo anti-influenza virus activity of 5,7,40- trihydroxy-8-methoxyflavone by drug delivery system using hydroxypropyl cellulose. Biol Pharm Bull 20:1082-1085 (Pubitemid 27497993)
24. Watanabe W, Konno K, Ijichi K, Inoue H, Yokota T, Shigeta S (1994) MTT colorimetric assay system for the screening of antiorthomyxo- and anti-paramyxoviral agents. J Virol Methods 48:257-265
25. Miki K, Nagai T, Suzuki K, Tsujimura R, Koyama K, Kinoshita K, Furuhata K, Yamada H, Takahashi K (2007) Anti-influenza virus activity of biflavonoids. Bioorg Med Chem Lett 17:772-775 (Pubitemid 46108558)