The effects of subarachnoid administration of preservative-free S(+)-ketamine on spinal cord and meninges in dogs

Anesthesia and Analgesia

Volumn 114, Issue 2, 2012, Pages 450-455

  Rojas, Alfredo Cury ^a   Alves, Juliana Gaiotto ^a   Moreira E Lima, Rodrigo ^a   Esther Alencar Marques, Mariângela ^a   Moreira De Barros, Guilherme Antônio ^a   Fukushima, Fernanda Bono ^a   Modolo, Norma Sueli Pinheiro ^a   Ganem, Eliana Marisa ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

EOSIN; ESKETAMINE; ETOMIDATE; FENTANYL; GLIAL FIBRILLARY ACIDIC PROTEIN; HEMATOXYLIN; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CAUDA EQUINA; CELL ACTIVATION; CELL COUNT; CLINICAL OBSERVATION; CONTROLLED STUDY; DEMYELINATION; DRUG EFFECT; EXPERIMENTAL DOG; FEMALE; HISTOPATHOLOGY; MALE; MENINX; MICROSCOPY; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE; SPINAL CORD; STAINING;

ANALGESICS; ANIMALS; CELL DEATH; CHEMISTRY, PHARMACEUTICAL; DOGS; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; GLIAL FIBRILLARY ACIDIC PROTEIN; INJECTIONS, SPINAL; KETAMINE; MALE; MENINGES; MYELIN SHEATH; PRESERVATIVES, PHARMACEUTICAL; RANDOM ALLOCATION; SPINAL CORD; TIME FACTORS;

EID: 84856228644     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ANE.0b013e31823a5d1b     Document Type: Article

References (33)

1. Arditti J, Spadari M, de Haro L, Brun A, Bourdon JH, Valli M. Ketamine-dreams and realities. Acta Clin Belg 2002:Suppl:31-3
2. Subramaniam K, Subramaniam B, Steinbrook RA. Ketamine as adjuVant analgesic to opioids: a quantitative and qualitative systematic review. Anesth Analg 2004;99:482-95 (Pubitemid 38970424)
3. Petrenko AB, Yamakura T, Baba H, Shimoji K. The role of N-methyl-D-aspartate (NMDA) receptors in pain: a review. Anesth Analg 2003;97:1108-16 (Pubitemid 37158698)
4. Hocking G, Cousins MJ. Ketamine in chronic pain management: an evidence-based review. Anesth Analg 2003;97:1730-9 (Pubitemid 37475130)
5. Walker SM, Goudas LC, Cousins MJ, Carr DB. Combination spinal analgesic chemotherapy: a systematic review. Anesth Analg 2002;95:674-715 (Pubitemid 35006863)
6. Oye I, Paulsen O, Maurset A. Effects of ketamine on sensory perception: evidence for a role of N-methyl-D-aspartate receptors. J Pharmacol Exp Ther 1992;260:1209-13
7. Eisenach JC, Yaksh TL. Epidural ketamine in healthy children-what's the point? Anesth Analg 2003;96:626
8. Vranken JH, Troost D, Wegener JT, Kruis MR, Van Der Vegt MH. Neuropathological findings after continuous intrathecal administration of S(-)-ketamine for the management of neuropathic cancer pain. Pain 2005;117:231-5 (Pubitemid 41764792)
9. Ahuja BR. Analgesic effect of intrathecal ketamine in rats. Br J Anaesth 1983;55:991-5 (Pubitemid 13017011)
10. Borgbjerg FM, Svensson BA, Frigast C, Gordh T Jr. Histopathology after repeated intrathecal injections of preservativefree ketamine in the rabbit: a light and electron microscopic examination. Anesth Analg 1994;79:105-11 (Pubitemid 24203441)
11. Errando CL, Sifre C, Moliner S, Valia JC, Gimeno O, Minguez A, Boils P. Subarachnoid ketamine in swine-pathological findings after repeated doses: acute toxicity study. Reg Anesth Pain Med 1999;24:146-52 (Pubitemid 29169577)
12. Malinovsky JM, Cozian A, Lepage JY, Mussini JM, Pinaud M, Souron R. Ketamine and midazolam neurotoxicity in the rabbit. Anesthesiology 1991;75:91-7
13. Malinovsky JM, Lepage JY, Cozian A, Mussini JM, Pinaud M, Souron R. Is ketamine or its preservative responsible for neurotoxicity in the rabbit? Anesthesiology 1993;78:109-15 (Pubitemid 23038985)
14. Yaksh TL, Tozier N, Horais KA, Malkmus S, Rathbun M, Lafranco L, Eisenach J. Toxicology profile of N-methyl-Daspartate antagonists delivered by intrathecal infusion in the canine model. Anesthesiology 2008;108:938-49 (Pubitemid 351589491)
15. Bogduk N. Epidural Use of Steroids in the Management of Back Pain and Sciatica of Spinal Origin. Canberra: Commonwealth of Australia, 1994
16. Hendrix PK, Raffe MR, Robinson EP, Felice LJ, Randall DA, Epidural administration of bupivacaine, morphine, or their combination for postoperative analgesia in dogs. J Am Vet Med Assoc 1996;209:598-607 (Pubitemid 26252158)
17. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983;16:109-10 (Pubitemid 13058546)
18. Collins TJ. ImageJ for microsopy. Biotechniques 2007;43:25-30
19. Fleiss JL, Levin BA, Paik MC. Statistical Methods for Rates and Proportions, 3rd ed. Hoboken, NJ: J. Wiley, 2003
20. Team RDC. R: A Language and Environment for Statistical Computing. In: Computing RFfS ed. Vienna, Austria, 2006
21. Vadivelu N, Mitra S, Narayan D. Recent adVances in postoperative pain management. Yale J of Biology and Med 2010;83:11-25
22. Walker SM, Westin BD, Deumens R, Grafe M, Yaksh TL. Effects of intrathecal ketamine in the neonatal rat: evaluation of apoptosis and long-term functional outcome. Anesthesiology 2010;113:147-59
23. Himmelseher S, Durieux ME. Ketamine for perioperative pain management. Anesthesiology 2005;102:211-20 (Pubitemid 40082858)
24. Himmelseher S, Ziegler-Pithamitsis D, Argiriadou H, Martin J, Jelen-Esselborn S, Kochs E. Small-dose S(-)-ketamine reduces postoperative pain when applied with ropivacaine in epidural anesthesia for total knee arthroplasty. Anesth Analg 2001;92:1290-5 (Pubitemid 32385960)
25. Subramaniam K, Subramaniam B, Pawar DK, Kumar L. Evaluation of the safety and efficacy of epidural ketamine combined with morphine for postoperative analgesia after major upper abdominal surgery. J Clin Anesth 2001;13:339-44 (Pubitemid 32720489)
26. Pires SR, Ganem EM, Marques M, Castiglia YM. Effects of increasing spinal hyperbaric lidocaine concentrations on spinal cord and meninges: experimental study in dogs. Rev Bras Anestesiol 2006;56:253-62 (Pubitemid 43854442)
27. Ganem EM, Vianna PT, Marques M, Castiglia YM, Vane LA. Neurotoxicity of subarachnoid hyperbaric bupivacaine in dogs. Reg Anesth 1996;21:234-8 (Pubitemid 26152763)
28. Fukushima FB, Barros GA, Marques ME, Vidal EL, Ganem EM. The neuraxial effects of intraspinal amitriptyline at low concentrations. Anesth Analg 2009;109:965-71
29. Farber NB, Kim SH, Dikranian K, Jiang XP, Heinkel C. Receptor mechanisms and circuitry underlying NMDA antagonist neurotoxicity. Mol Psychiatry 2002;7:32-43 (Pubitemid 34087877)
30. Hoyte L, Barber PA, Buchan AM, Hill MD. The rise and fall of NMDAantagonists for ischemic stroke. Curr Mol Med 2004;4:131-6 (Pubitemid 38425910)
31. Vranken JH, Van der Vegt MH, Kal JE, Kruis MR. Treatment of neuropathic cancer pain with continuous intrathecal administration of S-ketamine. Acta Anaesthesiol Scand 2004;48:249-52 (Pubitemid 38166472)
32. Kozec SA, Sator-Katzenschlager S, Kress HG. IntrathecalS(-) ketamine in refractory neuropathic cancer pain. Pain 2006;121:283-4
33. Vranken JH, Troost D, de Haan P, Pennings FA, Van der Vegt MH, Dijkgraaf MG, Hollmann MW. Severe toxic damage to the rabbit spinal cord after intrathecal administration of preservativefree S(-)-ketamine. Anesthesiology 2006;105:813-8 (Pubitemid 44477328)