Very early diagnosis of chest pain by point-of-care testing: Comparison of the diagnostic efficiency of a panel of cardiac biomarkers compared with troponin measurement alone in the RATPAC trial

Heart

Volumn 98, Issue 4, 2012, Pages 312-318

  Collinson, Paul ^a,b   Goodacre, Steve ^c   Gaze, David ^a   Gray, Alasdair ^d  

^a ST GEORGE S HOSPITAL   (United Kingdom)

^b ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

^d ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CREATINE KINASE MB; MYOGLOBIN; TROPONIN I;

ACUTE HEART INFARCTION; ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; EARLY DIAGNOSIS; FEMALE; FOLLOW UP; HUMAN; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; MEDICAL DECISION MAKING; OUTCOME ASSESSMENT; POINT OF CARE TESTING; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RECEIVER OPERATING CHARACTERISTIC; REFERENCE VALUE; RISK ASSESSMENT; RISK FACTOR; SENSITIVITY ANALYSIS; THORAX PAIN; TREATMENT PLANNING; VALIDATION PROCESS;

ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CHEST PAIN; CREATINE KINASE, MB FORM; DIAGNOSIS, DIFFERENTIAL; EARLY DIAGNOSIS; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; MYOGLOBIN; PROGNOSIS; PROSPECTIVE STUDIES; ROC CURVE; TIME FACTORS; TROPONIN I; YOUNG ADULT;

EID: 84856227860     PISSN: 13556037     EISSN: 1468201X     Source Type: Journal    
DOI: 10.1136/heartjnl-2011-300723     Document Type: Article

References (20)

1. McCord J, Nowak RM, McCullough PA, et al. Ninety-minute exclusion of acute myocardial infarction by use of quantitative point-of-care testing of myoglobin and troponin I. Circulation 2001;104:1483-8. (Pubitemid 32917339)
2. Ng SM, Krishnaswamy P, Morissey R, et al. Ninety-minute accelerated critical pathway for chest pain evaluation. Am J Cardiol 2001;88:611-17. (Pubitemid 32831092)
3. Than M, Cullen L, Reid CM, et al. A 2-h diagnostic protocol to assess patients with chest pain symptoms in the Asia - Pacific region (ASPECT): a prospective observational validation study. Lancet 2011;377:1077-84.
4. Apple FS. A new season for cardiac troponin assays: it's time to keep a scorecard. Clin Chem 2009;55:1303-6.
5. Collinson PO, Clifford-Mobley O, Gaze D, et al. Assay imprecision and 99th-percentile reference value of a high-sensitivity cardiac troponin I assay. Clin Chem 2009;55:1433-4.
6. Apple FS, Pearce LA, Smith SW, et al. Role of monitoring changes in sensitive cardiac troponin I assay results for early diagnosis of myocardial infarction and prediction of risk of adverse events. Clin Chem 2009;55:930-7.
7. Kavsak PA, Ko DT, Wang X, et al. Increasing cardiac troponin changes measured by a research high-sensitivity troponin I assay: absolute vs percentage changes and long-term outcomes in a chest pain cohort. Clin Chem 2010;56:1902-4.
8. Goodacre SW, Bradburn M, Cross E, et al. The Randomised Assessment of Treatment using Panel Assay of Cardiac Markers (RATPAC) trial: a randomised controlled trial of point-of-care cardiac markers in the emergency department. Heart 2011;97:190-6.
9. Thygesen K, Alpert JS, White HD, et al. Universal definition of myocardial infarction. Circulation 2007;116:2634-53. (Pubitemid 350182388)
10. Goodacre SW, Morris FM, Campbell S, et al. A prospective, observational study of a chest pain observation unit in a British hospital. Emerg Med J 2002;19:117-21. (Pubitemid 34279609)
11. Loten C, Attia J, Hullick C, et al. Point of care troponin decreases time in the emergency department for patients with possible acute coronary syndrome: a randomised controlled trial. Emerg Med J 2010;27:194-8.
12. Ryan RJ, Lindsell CJ, Hollander JE, et al. A multicenter randomized controlled trial comparing central laboratory and point-of-care cardiac marker testing strategies: the Disposition Impacted by Serial Point of Care Markers in Acute Coronary Syndromes (DISPOeACS) trial. Ann Emerg Med 2009;53:321-8.
13. Renaud B, Maison P, Ngako A, et al. Impact of point-of-care testing in the emergency department evaluation and treatment of patients with suspected acute coronary syndromes. Acad Emerg Med 2008;15:216-24.
14. Collinson PO, John C, Lynch S, et al. A prospective randomized controlled trial of point-of-care testing on the coronary care unit. Ann Clin Biochem 2004;41:397-404. (Pubitemid 39279926)
15. Eggers KM, Oldgren J, Nordenskjold A, et al. Diagnostic value of serial measurement of cardiac markers in patients with chest pain: limited value of adding myoglobin to troponin I for exclusion of myocardial infarction. Am Heart J 2004;148:574-81. (Pubitemid 39349374)
16. Dekker MS, Mosterd A, van 't Hof AW, et al. Novel biochemical markers in suspected acute coronary syndrome: systematic review and critical appraisal. Heart 2010;96:1001-10.
17. Reichlin T, Hochholzer W, Bassetti S, et al. Early diagnosis of myocardial infarction with sensitive cardiac troponin assays. N Engl J Med 2009;361:858-67.
18. Keller T, Zeller T, Peetz D, et al. Sensitive troponin I assay in early diagnosis of acute myocardial infarction. N Engl J Med 2009;361:868-77.
19. Collinson PO, Gaze DC, Morris F, et al. Comparison of biomarker strategies for rapid rule out of myocardial infarction in the emergency department using ACC/ESC diagnostic criteria. Ann Clin Biochem 2006;43:273-80. (Pubitemid 44049690)
20. Straface AL, Myers JH, Kirchick HJ, et al. A rapid point-of-care cardiac marker testing strategy facilitates the rapid diagnosis and management of chest pain patients in the emergency department. Am J Clin Pathol 2008;129:788-95.