P.O.P.A. Study: Prevention of Postoperative Abdominal Adhesions by Icodextrin 4% Solution After Laparotomy for Adhesive Small Bowel Obstruction. A Prospective Randomized Controlled Trial

Journal of Gastrointestinal Surgery

Volumn 16, Issue 2, 2012, Pages 382-388

  Catena, Fausto ^a   Ansaloni, Luca ^a   Saverio, Salomone Di ^a   Pinna, Antonio D ^b  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b NONE

Author keywords

Abdominal adhesions; Adhesive small bowel obstruction; Icodextrin; Prevention of adhesions formation; Randomized controlled trial

Indexed keywords

GLUCAN; GLUCOSE; ICODEXTRIN;

AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; FOLLOW UP; HUMAN; INTESTINE OBSTRUCTION; LAPAROTOMY; MALE; MIDDLE AGED; PERITONEAL DISEASE; POSTOPERATIVE COMPLICATION; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; SINGLE BLIND PROCEDURE; TISSUE ADHESION; TREATMENT OUTCOME;

AGED; FEMALE; FOLLOW-UP STUDIES; GLUCANS; GLUCOSE; HUMANS; INTESTINAL OBSTRUCTION; LAPAROTOMY; MALE; MIDDLE AGED; PERITONEAL DISEASES; POSTOPERATIVE COMPLICATIONS; PROSPECTIVE STUDIES; RECURRENCE; SINGLE-BLIND METHOD; TISSUE ADHESIONS; TREATMENT OUTCOME;

EID: 84856224783     PISSN: 1091255X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11605-011-1736-y     Document Type: Article

References (24)

1. Di Saverio S, Catena F, Ansaloni L, Gavioli M, Valentino M, Pinna AD. Water-soluble contrast medium (gastrografin) value in adhesive small intestine obstruction (ASIO): a prospective, randomized, controlled, clinical trial. World J Surg. 2008; 32(10): 2293-304.
2. Fevang BT, Fevang J, Lie SA, Soreide O, Svanes K, Viste A. Long term prognosis after operation for adhesive small bowel obstruction. Ann Surg 2004, 240(2): 193-201.
3. Ellis H. The clinical significance of adhesion: focus on intestinal obstruction. Eur J Surg Suppl 1997: 5-9.
4. Di Saverio S, Tugnoli G, Catena F, Biscardi A, Baldoni F. Spiller R. A tenacious complete small bowel obstruction. Gut. 2009; 58(6): 812-891.
5. Menzies D. Prospective adhesions: their treatment and relevance in clinical practice. Ann R Coll Surg Engl 1993, 75: 147-53.
6. Ellis H: The magnitude of adhesion-related problems. Ann Chir Gynaecol 1998, 87: 9-11.
7. Ray NF, Denton WG, Thamer M, Henderson SC, Perry S: Abdominal adhesiolysis: inpatient care and expenditures in the United States in 1994 J Am Coll Surg 1998, 186: 1-9.
8. Metwally M, Watson A, Lilford R, Vandekerckhove P. Fluid and pharmacological agents for adhesion prevention after gynaecological surgery. Cochrane Database Syst Rev. 2006;(2): CD001298.
9. Verco SJ, Peers EM, Brown CB, Rodgers KE, Roda N, diZerega G. Development of a novel glucose polymer solution (icodextrin) for adhesion prevention: pre-clinical studies. Hum Reprod. 2000; 15(8): 1764-72.
10. Müller SA, Treutner KH, Anurov M, Titkova S, Oettinger AP, Schumpelick V. Experimental evaluation of phospholipids and icodextrin in re-formation of peritoneal adhesions. Br J Surg. 2003; 90(12): 1604-7.
11. Johnson DW, Agar J, Collins J, Disney A, Harris DC, Ibels L, Irish A, Saltissi D, Suranyi M. (2003) Recommendations for the use of icodextrin in peritoneal dialysis patients. Nephrology (Carlton) 8(1): 1-7.
12. Brown CB, Luciano AA, Martin D, Peers E, Scrimgeour A, diZerega GS; Adept Adhesion Reduction Study Group. Adept (icodextrin 4% solution) reduces adhesions after laparoscopic surgery for adhesiolysis: a double-blind, randomized, controlled study. Fertil Steril. 2007 Nov; 88(5): 1413-26.
13. diZerega GS, Verco SJ, Young P, Kettel M, Kobak W, Martin D, Sanfilippo J, Peers EM, Scrimgeour A, Brown CB. A randomized, controlled pilot study of the safety and efficacy of 4% icodextrin solution in the reduction of adhesions following laparoscopic gynaecological surgery. Hum Reprod. 2002 Apr; 17(4): 1031-8.
14. Catena F, Ansaloni L, Lauro A, Ercolani G, D'Alessandro L, Pinna A. Prospective controlled randomized trial on prevention of postoperative abdominal adhesions by Icodextrin 4% solution after laparotomic operation for small bowel obstruction caused by adherences [POPA study: Prevention of Postoperative Adhesions on behalf of the World Society of Emergency Surgery]. Trials. 2008; 9: 74.
15. Di Saverio S, Tugnoli G, Orlandi PE, Casali M, Catena F, Biscardi A, Pillay O, Baldoni F. A 73-year-old man with long-term immobility presenting with abdominal pain. PLoS Med. 2009 Jul 14; 6(7): e1000092. Epub 2009 Jul 14.
16. Diaz JJ Jr, Bokhari F et al. Guidelines for management of small bowel obstruction J Trauma. 2008; 64(6): 1651-64.
17. Eastern Association for the Surgery of Trauma Practice Parameter Workgroup for Management of Small Bowel Obstruction. Practice management guidelines for small bowel obstruction 2007. www. east. org.
18. Catena F., Di Saverio S., Kelly M., Biffl W., Mandalà V., Ansaloni L, Velmahos G., Sartelli M., G. Tugnoli, M. Lupo, S. Mandalà, Pinna AD, Sugarbaker PH, H. VanGoor, Moore EE., Jeekel J. Bologna Guidelines for Diagnosis and Management of ADHESIVE SMALL BOWEL OBSTRUCTION: 2010 Evidence-Based Guidelines of the World Society of Emergency Surgery World Journal of Emergency Surgery 2011, 6: 5.
19. Brown CB, Luciano AA, Martin D, Peers E, Scrimgeour A, diZerega GS: Adept [icodextrin 4% solution] reduces adhesions after laparoscopic surgery for adhesiolysis: a double-blind, randomized, controlled study. Fertil Steril 2007, 88(5): 1413-26.
20. Baca B, Boler DE, Onur E, Akca O, Hamzaoglu I, Karahasanoglu T, Erdamar S, Atukeren P, Dirican A. Icodextrin and Seprafilm do not interfere with colonic anastomosis in rats. Eur Surg Res. 2007; 39(5): 318-23.
21. van den Tol P, ten Raa S, van Grevenstein H, Marquet R, van Eijck C, Jeekel H. Icodextrin reduces postoperative adhesion formation in rats without affecting peritoneal metastasis. Surgery. 2005; 137(3): 348-54.
22. Rodgers KE, Verco SJ, diZerega GS. Effects of intraperitoneal 4% icodextrin solution on the healing of bowel anastomoses and laparotomy incisions in rabbits. Colorectal Dis. 2003; 5(4): 324-30.
23. Kössi J, Grönlund S, Uotila-Nieminen M, Crowe A, Knight A, Keränen U. The effect of 4% icodextrin solution on adhesiolysis surgery time at the Hartmann's reversal: a pilot, multicentre, randomized control trial vs lactated Ringer's solution. Colorectal Dis. 2009; 11(2): 168-72.
24. Menzies D, Pascual MH, Walz MK, Duron JJ, Tonelli F, Crowe A, Knight A; ARIEL Registry. Use of icodextrin 4% solution in the prevention of adhesion formation following general surgery: from the multicentre ARIEL Registry. Ann R Coll Surg Engl. 2006; 88(4): 375-82.