Nicotinic acid hydrazones: A novel anticonvulsant pharmacophore

Medicinal Chemistry Research

Volumn 20, Issue 9, 2011, Pages 1499-1504

  Sinha, Reema ^a   Sara, U V Singh ^b   Khosa, R L ^c   Stables, James ^d   Jain, Jainendra ^a  

^a Ram Eesh Institute of Vocational & Technical Education   (India)

^b DJ College of Pharmacy   (India)

^c BHARAT INSTITUTE OF TECHNOLOGY   (India)

^d NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

Anticonvulsant activity; Antiepileptic drug design; Aryl acid hydrazones; Docking; GABA A; Maximal electroshock test; ScPTZ

Indexed keywords

AMINOTRANSFERASE; ANTICONVULSIVE AGENT; GAMMA AMINO BUTYRATE AMINOTRANSFERASE; HYDRAZONE DERIVATIVE; LYSINE; N1 (2 FLUOROBENZYLIDENE)BENZHYDRAZIDE; N1 (2 FLUOROBENZYLIDENE)ISONICOTINOHYDRAZIDE; N1 (2 NITROBENZYLIDENE)ISONICOTINOHYDRAZIDE; N1 (3 BROMOBENZYLIDENE)NICOTINOHYDRAZIDE; N1 (3 BROMOBENZYLIDENE)TOLYLHYDRAZIDE; N1 (3 CHLOROBENZYLIDENE)NICOTINOHYDRAZIDE; N1 (3 CHLOROBENZYLIDENE)TOLYLHYDRAZIDE; N1 (4 CHLOROBENZYLIDENE)ISONICOTINOHYDRAZIDE; N1 (4 CHLOROBENZYLIDENE)NICOTINOHYDRAZIDE; NICOTINIC ACID; NICOTINIC ACID HYDRAZONE; PHENYTOIN; SEMICARBAZONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; CLONIC SEIZURE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG BINDING; DRUG EFFECT; DRUG SYNTHESIS; ELECTRIC SHOCK; GENETIC ALGORITHM; MAXIMAL ELECTROSHOCK SEIZURE; MOLECULAR DOCKING; NONHUMAN; PHARMACOPHORE; RAT; SEIZURE;

EID: 84856221867     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-010-9396-0     Document Type: Conference Paper

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