Effects of atorvastatin on endothelial function and the expression of proinflammatory cytokines and adhesion molecules in young subjects with successfully repaired coarctation of aorta

Heart

Volumn 98, Issue 4, 2012, Pages 325-329

  Brili, S ^a   Tousoulis, Dimitris ^a   Antonopoulos, A S ^a   Antoniades, C ^a   Hatzis, G ^a   Bakogiannis, C ^a   Papageorgiou, N ^a   Stefanadis, C ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

ATORVASTATIN; CHOLESTEROL; INTERLEUKIN 1BETA; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; AORTA COARCTATION; AORTA RECONSTRUCTION; ARTICLE; CARDIOVASCULAR FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG MECHANISM; ENDOTHELIAL DYSFUNCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; INTERMETHOD COMPARISON; MALE; MYALGIA; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RHABDOMYOLYSIS; SIDE EFFECT;

ADULT; AORTIC COARCTATION; BIOLOGICAL MARKERS; CELL ADHESION MOLECULES; CYTOKINES; DISEASE PROGRESSION; ENDOTHELIUM, VASCULAR; FEMALE; FOLLOW-UP STUDIES; HEPTANOIC ACIDS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; POSTOPERATIVE PERIOD; PROGNOSIS; PROSPECTIVE STUDIES; PYRROLES; TIME FACTORS; VASCULAR SURGICAL PROCEDURES;

EID: 84856221255     PISSN: 13556037     EISSN: 1468201X     Source Type: Journal    
DOI: 10.1136/heartjnl-2011-300287     Document Type: Article

References (26)

1. Bobby JJ, Emami JM, Farmer RD, et al. Operative survival and 40 year follow up of surgical repair of aortic coarctation. Br Heart J 1991;65:271-6.
2. Dellipizzi A, Pucci ML, Mosny AY, et al. Contribution of constrictor prostanoids to the calcium-dependent basal tone in the aorta from rats with aortic coarctation-induced hypertension: relationship to nitric oxide. J Pharmacol Exp Ther 1997;283:75-81. (Pubitemid 27438948)
3. Meyer AA, Joharchi MS, Kundt G, et al. Predicting the risk of early atherosclerotic disease development in children after repair of aortic coarctation. Eur Heart J 2005;26:617-22. (Pubitemid 40461104)
4. Brili S, Tousoulis D, Antoniades C, et al. Evidence of vascular dysfunction in young patients with successfully repaired coarctation of aorta. Atherosclerosis 2005;182:97-103. (Pubitemid 41188374)
5. Gardiner HM, Celermajer DS, Sorensen KE, et al. Arterial reactivity is significantly impaired in normotensive young adults after successful repair of aortic coarctation in childhood. Circulation 1994;89:1745-50. (Pubitemid 24114253)
6. Brili S, Dernellis J, Aggeli C, et al. Aortic elastic properties in patients with repaired coarctation of aorta. Am J Cardiol 1998;82:1140-3, A10.
7. Ridker PM, Cannon CP, Morrow D, et al Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 (PROVE IT-TIMI 22) Investigators. C-reactive protein levels and outcomes after statin therapy. N Engl J Med 2005;352:20-8. (Pubitemid 40075677)
8. Ridker PM, Danielson E, Fonseca FA, et al. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med 2008;359:2195-207.
9. Antoniades C, Antonopoulos AS, Bendall JK, et al. Targeting redox signaling in the vascular wall: from basic science to clinical practice. Curr Pharm Des 2009;15:329-42.
10. Tousoulis D, Antoniades C, Katsi V, et al. The impact of early administration of low-dose atorvastatin treatment on inflammatory process, in patients with unstable angina and low cholesterol level. Int J Cardiol 2006;109:48-52.
11. Tousoulis D, Antoniades C, Vasiliadou C, et al. Effects of atorvastatin and vitamin C on forearm hyperaemic blood flow, asymmentrical dimethylarginine levels and the inflammatory process in patients with type 2 diabetes mellitus. Heart 2007;93:244-6. (Pubitemid 46180305)
12. Antoniades C, Bakogiannis C, Tousoulis D, et al. Preoperative atorvastatin treatment in CABG patients rapidly improves vein graft redox state by inhibition of Rac1 and NADPH-oxidase activity. Circulation 2010;122(11 Suppl):66-73.
13. Heitzer T, Schlinzig T, Krohn K, et al. Endothelial dysfunction, oxidative stress and risk of cardiovascular events in patients with coronary artery disease. Circulation 2001;104:2673-8. (Pubitemid 33108132)
14. Gidding SS, Rocchini AP, Moorehead C, et al. Increased Forearm vascular reactivity in patients with hypertension after repair of coarctation. Circulation 1985;71:495-9. (Pubitemid 15133807)
15. Schneeweiss A, Sherf L, Lehrer E, et al. Segmental study of the terminal coronary vessels in coarctation of the aorta: a natural model for study of the effect of coronary hypertension on human coronary circulation. Am J Cardiol 1982;49:1996-2002. (Pubitemid 12059057)
16. Ghaleh B, Hittinger L, Kim SJ, et al. Selective large coronary endothelial dysfunction in conscious dogs with chronic coronary pressure overload. Am J Physiol 1998;274:H539-51.
17. Heger M, Willfort A, Neunteufl T, et al. Vascular dysfunction after coarctation repair is related to the age at surgery. Int J Cardiol 2005;99:295-9. (Pubitemid 40320804)
18. Beekman RH, Katz BP, Moorehead-Steffens C, et al. Altered baroreceptor function in children with systolic hypertension after coarctation repair. Am J Cardiol 1983;52:112-17. (Pubitemid 13061337)
19. Tanous D, Benson LN, Horlick EM. Coarctation of the aorta: evaluation and management. Curr Opin Cardiol 2009;24:509-15.
20. Parker FB Jr, Streeten DH, Farrell B, et al. Preoperative and postoperative renin levels in coarctation of the aorta. Circulation 1982;66:513-14. (Pubitemid 12038571)
21. Brili S, Tousoulis D, Antoniades C, et al. Effects of ramipril on endothelial function and the expression of proinflammatory cytokines and adhesion molecules in young normotensive subjects with successfully repaired coarctation of aorta: a randomized cross-over study. J Am Coll Cardiol 2008;51:742-9. (Pubitemid 351221212)
22. Wenzel P, Daiber A, Oelze M, et al. Mechanisms underlying recoupling of Enos by Hmg-Coa reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus. Atherosclerosis 2008;198:65-76.
23. Ross R. Atherosclerosis - an inflammatory disease. N Engl J Med 1999;340:115-26. (Pubitemid 29054847)
24. Ridker PM, Hennekens CH, Buring JE, et al. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 2000;342:836-43. (Pubitemid 30165206)
25. Osmancik P, Bocsi J, Hambsch J, et al. Soluble endothelial adhesion molecule concentration in patients with aortic coarctation. Endothelium 2006;13:353-8. (Pubitemid 44712325)
26. Dichtl W, Dulak J, Frick M, et al. Hmg-Coa reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2003;23:58-63. (Pubitemid 36091626)