Alexithymia is a non-motor symptom of Parkinson disease

American Journal of Geriatric Psychiatry

Volumn 20, Issue 2, 2012, Pages 133-141

  Assogna, Francesca ^a   Palmer, Katie ^a   Pontieri, Francesco E ^b   Pierantozzi, Mariangela ^c   Stefani, Alessandro ^c   Gianni, Walter ^d   Caltagirone, Carlo ^a,c   Spalletta, Gianfranco ^e  

^a IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

^d INRCA   (Italy)

^e NONE

Author keywords

Alexithymia; Depressive disorders; Neuropsychiatric symptoms; Parkinson disease

Indexed keywords

20 ITEM TORONTO ALEXITHYMIA SCALE; AGED; ALEXITHYMIA; ARTICLE; BECK DEPRESSION INVENTORY; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DEPRESSION; DISEASE COURSE; DISEASE SEVERITY; FEMALE; HAMILTON ANXIETY SCALE; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MINOR DEPRESSION; PARKINSON DISEASE; PSYCHOLOGIC TEST; STRUCTURED INTERVIEW; SYMPTOM;

EID: 84856212423     PISSN: 10647481     EISSN: 15457214     Source Type: Journal    
DOI: 10.1097/JGP.0b013e318209de07     Document Type: Article

References (37)

1. Zesiewicz TA, Gold M, Chari G, et al: Current issues in depression in Parkinson's disease. Am J Geriatr Psychiatry 1999; 7:110-118 (Pubitemid 29165459)
2. Weintraub D, Stern MB: Psychiatric complications in Parkinson disease. Am J Geriatr Psychiatry 2005; 13:844-851 (Pubitemid 46638672)
3. Weintraub D, Oehlberg KA, Katz IR, et al: Test characteristics of the 15-item Geriatric Depression Scale and Hamilton Depression Rating Scale in Parkinson disease. Am J Geriatr Psychiatry 2006; 14:169-175 (Pubitemid 43227640)
4. Assogna F, Pontieri FE, Caltagirone C, et al: The recognition of facial emotion expressions in Parkinson's disease. Eur Neuropsychopharmacol 2008; 18:835-848
5. Jacobs DH, Shuren J, Bowers D, et al: Emotional facial imagery, perception, and expression in Parkinson's disease. Neurology 1995; 45:1696-1702
6. Benke T, Bosch S, Andree B: A study of emotional processing in Parkinson's disease. Brain Cogn 1998; 38:36-52 (Pubitemid 28450571)
7. Sifneos PE: The prevalence of 'alexithymic' characteristics in psychosomatic patients. Psychother Psychosom 1973; 22:255-262
8. Davidson RJ, Ekman P, Saron CD, et al: Approach-withdrawal and cerebral asymmetry: emotional expression and brain physiology. J Pers Soc Psychol 1990; 58:330-341
9. Jessimer M, Markham R: Alexithymia: a right hemisphere dysfunction specific to recognition of certain facial expressions? Brain Cogn 1997; 34:246-258 (Pubitemid 27291107)
10. McDonald PW, Prkachin KM: The expression and perception of facial emotion in alexithymia: a pilot study. Psychosom Med 1990; 52:199-210 (Pubitemid 20112436)
11. Parker JD, Keightley ML, Smith CT, et al: Interhemispheric transfer deficit in alexithymia: an experimental study. Psychosom Med 1999; 61:464-468 (Pubitemid 29360309)
12. Zeitlin SB, Lane RD, O'Leary DS, et al: Interhemispheric transfer deficit and alexithymia. Am J Psychiatry 1989; 146:1434-1439 (Pubitemid 19271381)
13. Spalletta G, Pasini A, Costa A, et al: Alexithymic features in stroke: effects of laterality and gender. Psychosom Med 2001; 63:944-950 (Pubitemid 33101380)
14. Devinsky O, Morrell MJ, Vogt BA: Contributions of anterior cingulate cortex to behaviour. Brain 1995; 118:279-306
15. Hornak J, Rolls ET, Wade D: Face and voice expression identification in patients with emotional and behavioural changes following ventral frontal lobe damage. Neuropsychologia 1996; 34:247-261 (Pubitemid 26079003)
16. Alexander GE, Crutcher MD, DeLong MR: Basal gangliathalamocortical circuits: parallel substrates for motor, oculomotor, "prefrontal" and "limbic" functions. Prog Brain Res 1990; 85:119-146
17. Kenny ER, O'Brien JT, Cousins DA, et al: Functional connectivity in late-life depression using resting-state functional magnetic resonance imaging. Am J Geriatr Psychiatry 2010; 18:643-651
18. Bermond B: Brain and alexithymia, in The (non) expression of emotion in health and disease. Edited by Vingerhots A, Van Bussen F, Boelhouwer J. Tilburg, Netherlands, Tilburg University Press, 1997, pp 115-131
19. Berman KF, Weinberger DR: The prefrontal cortex in schizophrenia and other neuropsychiatric diseases: in vivo physiological correlates of cognitive deficits. Prog Brain Res 1990; 85:521-536; discussion 36-37
20. Costa A, Peppe A, Carlesimo GA, et al: Alexithymia in Parkinson's disease is related to severity of depressive symptoms. Eur J Neurol 2006; 13:836-841 (Pubitemid 44124679)
21. Costa A, Peppe A, Carlesimo GA, et al: Neuropsychological correlates of alexithymia in Parkinson's disease. J Int Neuropsychol Soc 2007; 13:980-992 (Pubitemid 47617549)
22. Costa A, Peppe A, Carlesimo GA, et al: Prevalence and characteristics of alexithymia in Parkinson's disease. Psychosomatics 2010; 51:22-28
23. Parker JD, Taylor GJ, Bagby RM: The 20-Item Toronto Alexithymia Scale. III. Reliability and factorial validity in a community population. J Psychosom Res 2003; 55:269-275 (Pubitemid 38366231)
24. Cravello L, Caltagirone C, Spalletta G: The SNRI venlafaxine improves emotional unawareness in patients with post-stroke depression. Hum Psychopharmacol 2009; 24:331-336
25. Hughes AJ, Daniel SE, Kilford L, et al: Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 1992; 55:181-184
26. Folstein MF, Folstein SE, McHugh PR: "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12:189-198
27. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders. 4th ed. rev. Washington, DC, American Psychiatric Press, 2000
28. Langston W, Ballard P: Parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP): implications for treatment and the pathogenesis of Parkinson's disease. Can J Neurol Sci 1984; 11:160-165 (Pubitemid 14133460)
29. Beck AT, Steer RA (eds): Beck Depression Inventory Manual. San Antonio, TX, The Psychological Corporation, 1987
30. Hamilton M: The clinical distinction between anxiety and depression. Br J Clin Pharmacol 1983; 15 (Suppl 2):165S-169S (Pubitemid 13094490)
31. First MB, Spitzer RL, Gibbon M, et al (eds): Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition (SCID-I/P). New York, Biometrics Research, New York State Psychiatric Institute, 2002
32. Bagby RM, Taylor GJ, Parker JD: The Twenty-item Toronto Alexithymia Scale-II. Convergent, discriminant, and concurrent validity. J Psychosom Res 1994; 38:33-40
33. Bagby RM, Parker JD, Taylor GJ: The twenty-item Toronto Alexithymia Scale-I. Item selection and cross-validation of the factor structure. J Psychosom Res 1994; 38:23-32
34. Hintikka J, Honkalampi K, Lehtonen J, et al: Are alexithymia and depression distinct or overlapping constructs: a study in a general population. Compr Psychiatry 2001; 42: 234-239 (Pubitemid 32410928)
35. Honkalampi K, Hintikka J, Tanskanen A, et al: Depression is strongly associated with alexithymia in the general population. J Psychosom Res 2000; 48:99-104 (Pubitemid 30128573)
36. Sprengelmeyer R, Young AW, Mahn K, et al: Facial expression recognition in people with medicated and unmedicated Parkinson's disease. Neuropsychologia 2003; 41:1047-1057 (Pubitemid 36349396)
37. Takahashi H, Yahata N, Koeda M, et al: Effects of dopaminergic and serotonergic manipulation on emotional processing: a pharmacological fMRI study. Neuroimage 2005; 27: 991-1001 (Pubitemid 41317266)