Synthesis of 3-phenylsulfonylmethyl cyclohexylaminobenzamide-derived antagonists of CC chemokine receptor 2 (CCR2)

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 3, 2012, Pages 1384-1387

  Yang, Michael G ^a   Xiao, Zili ^a   Shi, Qing ^a   Cherney, Robert J ^a   Tebben, Andrew J ^a   De Lucca, George V ^a   Santella III, Joseph B ^a   Mo, Ruowei ^a   Cvijic, Mary Ellen ^a   Zhao, Qihong ^a   Barrish, Joel C ^a   Carter, Percy H ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Antagonist; CCR2; Chemokine; GPCR

Indexed keywords

3 PHENYLSULFONYLMETHYL CYCLOHEXYLAMINOBENZAMIDE DERIVATIVE; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR2 ANTAGONIST; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; INFLAMMATION; STRUCTURE ACTIVITY RELATION;

AMIDES; AMINOBENZOIC ACIDS; ANIMALS; CYCLIZATION; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MICROSOMES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; RATS; RECEPTORS, CCR2; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; SULFUR;

EID: 84856208740     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.12.057     Document Type: Article

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