Lp(a)-cholesterol is associated with HDL-cholesterol in overweight and obese African American children and is not an independent risk factor for CVD

Cardiovascular Diabetology

Volumn 11, Issue , 2012, Pages

  Sharma, Sushma ^a,b   Merchant, Jayshree ^c   Fleming, Sharon E ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

Author keywords

Atherosclerosis; BMIz; CVD; HDL; LDL; Lipoprotein; Lp(a); Obesity; TAG; TC; Waist circumference

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERMEDIATE DENSITY LIPOPROTEIN; LIPOPROTEIN A; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL; BIOLOGICAL MARKER;

AFRICAN AMERICAN; ARTICLE; BODY HEIGHT; BODY MASS; BODY WEIGHT; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CHILD; CHOLESTEROL BLOOD LEVEL; CROSS-SECTIONAL STUDY; FEMALE; HUMAN; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; OBESITY; PUBERTY; SCHOOL CHILD; WAIST CIRCUMFERENCE; AGE; BLOOD; ETHNOLOGY; MULTIVARIATE ANALYSIS; PILOT STUDY; RISK ASSESSMENT; RISK FACTOR; STATISTICAL MODEL; STATISTICS; UNITED STATES;

AFRICAN AMERICANS; AGE FACTORS; BIOLOGICAL MARKERS; BODY MASS INDEX; CALIFORNIA; CARDIOVASCULAR DISEASES; CHILD; CHOLESTEROL, HDL; CROSS-SECTIONAL STUDIES; HUMANS; LINEAR MODELS; LIPOPROTEIN(A); MULTIVARIATE ANALYSIS; OBESITY; OVERWEIGHT; PILOT PROJECTS; RISK ASSESSMENT; RISK FACTORS; WAIST CIRCUMFERENCE;

EID: 84856188278     PISSN: None     EISSN: 14752840     Source Type: Journal    
DOI: 10.1186/1475-2840-11-10     Document Type: Article

References (27)

1. Berg K. A new serum type system in man-the Lp system. Acta Pathol Microbiol Scand 1963, 59:369-382.
2. Utermann G, Weber W. Protein composition of Lp(a) lipoprotein from human plasma. FEBS Lett 1983, 154(2):357-361. 10.1016/0014-5793(83)80182-3, 6219896.
3. Djurovic S, Berg K. Epidemiology of Lp(a) lipoprotein: its role in atherosclerotic/thrombotic disease. Clin Genet 1997, 52(5):281-292.
4. Brown SA, et al. The relation of lipoprotein[a] concentrations and apolipoprotein[a] phenotypes with asymptomatic atherosclerosis in subjects of the Atherosclerosis Risk in Communities (ARIC) Study. Arterioscler Thromb 1993, 13(11):1558-1566. 10.1161/01.ATV.13.11.1558, 8218095.
5. Schreiner PJ. Lipoprotein(a) as a risk factor for preclinical atherosclerotic disease in a biracial cohort: the Atherosclerosis Risk in Communities (ARIC) Study. Chem Phys Lipids 1994, 67-68:405-410.
6. Moliterno DJ, et al. No association between plasma lipoprotein(a) concentrations and the presence or absence of coronary atherosclerosis in African-Americans. Arterioscler Thromb Vasc Biol 1995, 15(7):850-855. 10.1161/01.ATV.15.7.850, 7600116.
7. Dangas G, et al. Correlation of serum lipoprotein(a) with the angiographic and clinical presentation of coronary artery disease. Am J Cardiol 1999, 83(4):583-585. A7, 10.1016/S0002-9149(98)00917-5, 10073865.
8. Marcovina SM, et al. Lipoprotein[a] concentrations and apolipoprotein[a] phenotypes in Caucasians and African Americans. The CARDIA study. Arterioscler Thromb 1993, 13(7):1037-1045. 10.1161/01.ATV.13.7.1037, 8318505.
9. Pearson TA, et al. AHA Guidelines for Primary Prevention of Cardiovascular Disease and Stroke: 2002 Update: Consensus Panel Guide to Comprehensive Risk Reduction for Adult Patients Without Coronary or Other Atherosclerotic Vascular Diseases. American Heart Association Science Advisory and Coordinating Committee. Circulation 2002, 106(3):388-391. 10.1161/01.CIR.0000020190.45892.75, 12119259.
10. Onat A, et al. Lipoprotein (a) in a population-based study: more significant in Turkish women than men?. Anadolu Kardiyol Derg 2005, 5(4):271-277.
11. Heyden S, et al. Raised Lipoprotein(a) in Hypercholesterolemic Black-Students Compared to Age-Matched Whites in North and South-Carolina. Int J Epidemiol 1994, 23(2):301-306. 10.1093/ije/23.2.301, 8082956.
12. Dahlen GH, et al. Association of levels of lipoprotein Lp(a), plasma lipids, and other lipoproteins with coronary artery disease documented by angiography. Circulation 1986, 74(4):758-765. 10.1161/01.CIR.74.4.758, 2944670.
13. Howard BV, et al. Concentrations of Lp(a) in black and white young adults: relations to risk factors for cardiovascular disease. Ann Epidemiol 1994, 4(5):341-350. 10.1016/1047-2797(94)90067-1, 7981840.
14. Cunningham TE, Sayers SM, Singh GR. Lipoprotein(a) identifies cardiovascular risk in childhood: the Australian aboriginal birth cohort study. J Paediatr Child Health 2011, 47(5):257-261. 10.1111/j.1440-1754.2010.01955.x, 21244559.
15. Chu NF, et al. Lipoprotein profiles, not anthropometric measures, correlate with serum lipoprotein(a) values in children: the Taipei children heart study. Eur J Epidemiol 2000, 16(1):5-12. 10.1023/A:1007692419117, 10780336.
16. Giger JN, et al. Genetic predictors of coronary heart disease risk factors in premenopausal African-American women. Ethn Dis 2005, 15(2):221-232.
17. Randall OS, et al. Response of lipoprotein(a) levels to therapeutic life-style change in obese African-Americans. Atherosclerosis 2004, 172(1):155-160. 10.1016/j.atherosclerosis.2003.09.017, 14709370.
18. Berenson GS, et al. Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study. N Engl J Med 1998, 338(23):1650-1656. 10.1056/NEJM199806043382302, 9614255.
19. Hirschler V, et al. Waist circumference identifies primary school children with metabolic syndrome abnormalities. Diabetes Technol Ther 2007, 9(2):149-157. 10.1089/dia.2006.0017, 17425440.
20. van Vliet M, et al. Cardiometabolic risk variables in overweight and obese children: a worldwide comparison. Cardiovasc Diabetol 2011, 10(1):106. 10.1186/1475-2840-10-106, 3258193, 22114790.
21. Ritchie LD, et al. Taking action together: a YMCA-based protocol to prevent type-2 diabetes in high-BMI inner-city African American children. Trials 2010, 11:60. 10.1186/1745-6215-11-60, 2894820, 20492667.
22. Kulkarni KR, et al. Identification and cholesterol quantification of low density lipoprotein subclasses in young adults by VAP-II methodology. J Lipid Res 1995, 36(11):2291-2302.
23. Kulkarni KR, et al. Quantification of cholesterol in all lipoprotein classes by the VAP-II method. J Lipid Res 1994, 35(1):159-168.
24. Raman A, et al. Accuracy of self-assessed Tanner staging against hormonal assessment of sexual maturation in overweight African-American children. J Ped Endocrin Metab 2009, 22:609-622.
25. Kimm SY, et al. Correlates of lipoprotein(a) levels in a biracial cohort of young girls: the NHLBI Growth and Health Study. J Pediatr 1999, 135(2 Pt 1):169-176.
26. Herd SL, et al. Body fat, fat distribution and serum lipids, lipoproteins and apolipoproteins in African-American and Caucasian-American prepubertal children. Int J Obes Relat Metab Disord 2001, 25(2):198-204. 10.1038/sj.ijo.0801524, 11410820.
27. Corsetti JP, et al. Effect of weight loss on serum lipoprotein(a) concentrations in an obese population. Clin Chem 1991, 37(7):1191-1195.