Long-term treatment with Kigelia Africana fruit extract ameliorates the testicular toxicity following cisplatin administration in male Sprague-Dawley rats

Journal of Medicinal Plant Research

Volumn 5, Issue 3, 2011, Pages 388-397

  Azu, O O ^a   Duru, F I O ^a   Osinubi, A A ^a   Oremosu, A A ^a   Norohna, C C ^a   Okanlawon, A O ^a   Elesha, S O ^a  

^a UNIVERSITY OF LAGOS   (Nigeria)

Author keywords

Cisplatin; Kigelia africana; Long term treatment; Testicular toxicity

Indexed keywords

CATALASE; CISPLATIN; FOLLITROPIN; GLUTATHIONE; KIGELIA AFRICANA EXTRACT; LUTEINIZING HORMONE; MALONALDEHYDE; PLANT EXTRACT; TESTOSTERONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIGNONIACEAE; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; ENZYME ACTIVITY; FRUIT; HISTOPATHOLOGY; KIGELIA AFRICANA; LONG TERM CARE; MALE; NONHUMAN; RAT; SEMINIFEROUS TUBULE; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; TESTIS DISEASE; WEIGHT REDUCTION;

ANIMALIA; KIGELIA AFRICANA; RATTUS;

EID: 84856173057     PISSN: None     EISSN: 19960875     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Abioye AIR, Duru FIO, Noronha CC, Okanlawon AO (2003). Aqueous extract of the bark of Kigelia africana reverses early testicular damage induced by methanol extract of Carica papaya. Nig. J. Health Biomed. Sci., 2: 87-89.
2. Atessahin A, Karahan I, Turk G, Gur S, Yilmaz S, Ceribasi AO (2006a). Protective role of lycopene on cisplatin-induced changes in sperm characteriastics, testicular damage and oxidative stress in rats. Reprod. Toxicol., 21: 42-47.
3. Aydiner A, Aytekin Y, Topuz E (1997). Effects of cisplatin on testicular tissue and Leydig cell-pituitary axis. Oncol., 54: 74-78.
4. Azu OO, Duru FIO, Osinubi AA, Norohna CC, Elesha SO, Okanlawon AO (2009). Preliminary study on the androgenic effects of Kigelia africana fruit extract in male Sprague-Dawley rats. Mid. East Fert. Soc. J., (MEFSJ) 14(3): 1-7.
5. Azu OO, Duru FIO, Osinubi AA, Noronha CC, Elesha SO, Okanlawon AO (2010a). Preliminary studies on the antioxidant effect of Kigelia africana fruit extract (Bignoniaceae) in male Sprague-Dawley rats. Afr. J. Biotechnol., 9(9): 1374-1381.
6. Azu OO, Duru FIO, Osinubi AA, Noronha CC, Elesha SO, Okanlawon AO (2010b). Protective agent, Kigelia africana, against cisplatininduced renal oxidative injury in Sprague-Dawley rats. Asian J. Pharm.l Clin. Res., 3: 84-88.
7. Azu OO, Duru FIO, Osinubi AA, Oremosu AA, Noronha CC, Elesha SO, Okanlawon AO (2010c). Histomorphometric effects of Kigelia Africana (Bignoniaceae) fruit extract following short-term treatment with cisplatin in male Sprague-Dawley rats. Mid. East Fert. Soc. J., (MEFSJ) doi:10.1016/j.mefs.2010.07.001.
8. Buege JA, Aust SD (1978). Microsomal lipid peroxidation. Methods Enzymol., 52: 302-310.
9. Burkill HM (1985). The useful plants of west tropical Africa. Planta WT Afr., 1: 254-257.
10. Cardinal R, De Groot J, Huizing E, Veldman J, Smoorenburg G (2000). Cisplatin-induced ototoxicty: morphological evidence of spontaneous outer hair cell recovery in albino guinea pigs? Hear Res., 144: 147-156.
11. Duru FIO, Olabiyi O, Noronha CC, Akinwande AI, Okanlawon AO (2008). Brief ischaemia reduces testicular lipid peroxidation following subsequent ischaemia: an evidence for ischaemic preconditioning. Nig. Q. J. Hosp. Med., 18: 149-152.
12. Gilliland KO, Freel CD, Lane CW, Fowler WC, Costello MJ (2001). Multilamellar bodies as potential scattering particles in human agerelated nuclear cataracts. Molecular Vision., 7: 120-130.
13. Graham JG, Quinn ML, Fabricant DS, Farnsworth NR (2000). Plants used against cancer-an extension of the work of Jonathan Hartwell. J. Ethnopharmacol., 73: 347-377.
14. Gundersen HJG (1977). Notes on the edge of the numerical density of arbitrary profiles: the edge effect. J. Microsc., 111: 219-223.
15. Gunderson HJG, Jenson EB (1987). The efficiency of systematic sampling in stereology and its prediction. J. Microsc., 147: 229-263.
16. Inuwa IM (2005). First order stereology in diabetes and endocrine research-number and volume estimation. Int. J. Diabetes Metabol., 13: 10-17.
17. Jeong UJ, Shin YG, Kim IH, Pezzuto JM (1999). Inhibition of aromatase activity by flavonoids. Arch. Pharm. Res., 22: 309-312.
18. Kawakami E, Takemura A, Sakuma M, takano M, Hirano T, Hori T, Tsutsui T (2007). Superoxide dismutase and catalase activities in the seminal plasma of normospermic and asthenozoospermic beagles. J. Vet. Med. Sci., 69: 133-136.
19. Kintzios SE (2006). Terrestrial plant-derived anticancer agents and plant species used in anticancer research. Crit. Rev. Plant Sci., 25: 79-113.
20. Kolodziej H (1997). Protective role of Kigelia africana fruits against benzo(a)pyrene-induced fore-stomach tumourigenesis in mice and against albumen-induced inflammation in rats. Pharm. Pharmacol. Lett., 7: 67-70.
21. Leblanc GA, Waxman DJ (1988). Feminisation of rat hepatic P-450 expression by cisplatin: Evidence for perturbations in the hormonal regulation of steroid-metabolising enzymes. J. Biol. Chem., 263: 15732-15739.
22. LeBlanc GA, Kantoff PW, Sze-Fong N, Frei E, Waxman DJ (1990). Hormonal perturbations in patients with testicular cancer treated with cisplatin. Cancer Cytopathol., 69: 2306-2310.
23. Marcon L, Hale BF, Robaire B (2008). Reversibility of subchronic exposure to cancer chemotherapeutics, bleomycin, etoposide and cisplatin (BEP) on spermatogenesis, fertility and progeny outcome in the male rat. J. Androl., Epub ahead of print.
24. Montine TJ, Borch RF (1990). Role of endogenous sulfur containing nucleophiles in an in vitro model of cis-diamminedichloroplatiniuminduced nephrotoxicity. Biochem. Pharmacol., 39: 1751-1757.
25. Morakinyo AO, Adeniyi OS, Arikawe AP (2008). Effects of Zingiber officinale on reproductive functions in male rat. Afr. J. Biomed. Res., 11: 329-333.
26. Nakai M, Hess RA, Netsu J, Nasu T (1995). Deformation of the rat Sertoli cell by oral administration of carbendazim (methyl 2-benzimidazole carbamate). J. Androl., 16: 410-416.
27. Narayana K, Prashanthi N, Nayanatara A, Biary LK, D'Souza UJ (2006). An organophosphate insecticide methyl parathion (O, O-dimethyl O-4-nitrophenyl phosphorothioate) induces cytotoxic damage and tubular atrophy in the testis despite elevated testosterone level in the rat. J. Toxicol. Sci., 31: 177-189.
28. Ogbeche KA, Ogunbiyi YO, Duru FIO (2002). Effect of methanol extract of Kigelia africana on sperm motility and fertility in rats. Nig. J. Health Biomed. Sci., 2: 113-116.
29. Okobia MN (2003). Cancer care in sub-saharan Africa-urgent need for population-based Cancer Registries. Ethiop. J. Health Dev., 17: 89-98.
30. Oliver-Bever B (1986). Medicinal plants in Tropical West Africa, Cambridge University Presss: Cambridge, London, New York, New Rochelle, Melbourne., p. 240.
31. Owolabi OJ, Omogbai EKI (2007). Analgesic and anti-inflammatory activities of the ethanolic stem bark extract of Kigelia Africana (Bignoniaceae). Afr. J. Biotechnol., 6: 582-585.
32. Picerno P, Autore G, Marzocco S, Meloni M, Sanogo R, Aquino RP (2005). Anti-inflammatory activity of verminoside from Kigelia Africana and evaluation of cutaneous irritation in cell cultures and reconstituted human epidermis. J. Nat. Prod., 68: 1610-1614.
33. Qin D, Lung MA (2002). Morphometric study on Leydig cells in capsuloptomised testis. Asian J. Androl., 4: 49-53.
34. Richburg JH, Boekelheide K (1996). Mono-(2-ethylhexyl) phthalate rapidly alters both Sertoli cell vimentin filaments and germ cells apoptosis in young rat testes. Toxicol. Appl Pharmacol., 137: 42-50.
35. Rudin CM, Yang Z, Schumaker LM, Vander Weele DJ, Newkirk K, Egorin MJ (2003). Inhibition of glutathione synthesis reverses Bcl-2-mediated cisplatin resistance. Cancer Res., 63: 312-318.
36. Rukkumani R, Aruna K, Varma PS, Rajasekaran KN, Menon VP (2004). Comparative effects of curcumin and an analogue of curcumin on alcohol and PUFA induced oxidative stress. J. Pharm. Pharm. Sci., 7: 274-283.
37. Rybak L, Hussain K, Morris C, Whitworth C, Somani S (2000). Effect of protective agents against cisplatin oto-toxicity. Am. J. Otol., 21: 513-520.
38. Sawhney P, Giammona CJ, Meiatrich ML, Richburg JH (2005). Cisplatin-induced long-term failure of spermatogenesis in adult C57/B1/6J mice. J. Androl. 26: 136-145.
39. Schrader M, Muller M, Straub B, Miller K (2002). Testicular sperm extraction in azoospermic patients with gonadal germ cell tumours prior to chemotherapy-a new therapy option. Asian J. Androl., 4: 9-15.
40. Seaman F, Sawhney E, Giammona CJ, Richburg JH (2003). Cisplatininduced pulse of germ cell apoptosis precedes long-term elevated apoptotic rates in C57/BL/6 mouse testis. Apoptosis., 8: 101-108.
41. Spermon JR, Ramos L, Wetzels AMM, Sweep CGJ, Braat DDM (2006). Sperm integrity pre-and post-chemotherapy in men with testicular germ cell cancer. Hum. Reprod., 21: 1781-1786.
42. Suzuki N, Sofikitis N (1999). Protective effects of antioxidants on testicular functions of varicocelized rats. Yonago Acta Medica., 42: 87-94.
43. Venkatesh V, Sharma JD, Kamal R (2002). A comparative study of effect of alcoholic extracts of Sapindus emarginatus, Terminalia belerica, Cuminum cyminum and Allium cepa on reproductive organs of male albino rats. Asian J. Exp. Sci., 1 and 2: 51-63.
44. Weiss RB, Christian MC (1993). New cisplatin analogues in development. A review. Drugs, 46: 360-377.
45. Yao X, Panichpisal K, Kurtzman N and Nugent K (2007). Cisplatin nephrotoxicity: A review. Am. J. Med Sci., 334: 115-124.
46. Zalata AA, Christophe AB, Depuydt CE, Schoonjans F, Comhaire FH (1998). White blood cells cause oxidative damage to the fatty acid composition of phospholipids of human spermatozoa. Int. J. Androl., 21: 154-162.