NADPH oxidase and PKC contribute to increased na transport by the thick ascending limb during type 1 diabetes

Hypertension

Volumn 59, Issue 2 SUPPL. 1, 2012, Pages 431-436

  Yang, Jing ^a   Pollock, Jennifer S ^b   Carmines, Pamela K ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

NADPH oxidase; oxygen consumption; protein kinase C; sodium reabsorption; thick ascending limb; type 1 diabetes

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; APOCYNIN; CALPHOSTIN C; FUROSEMIDE; OUABAIN; PROTEIN KINASE C; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SODIUM POTASSIUM CHLORIDE COTRANSPORTER; STREPTOZOCIN; SUPEROXIDE; ENZYME INHIBITOR; LOOP DIURETIC AGENT; PROTEIN KINASE C ALPHA; SODIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; DIABETIC NEPHROPATHY; ENZYME ACTIVATION; ENZYME INHIBITION; HYPERTENSION; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY; MEDULLARY THICK ASCENDING LIMB; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT; SODIUM ABSORPTION; SODIUM CELL LEVEL; SODIUM TRANSPORT; ADRENAL MEDULLA; CARDIOVASCULAR RISK; INTRACELLULAR TRANSPORT; RISK ASSESSMENT; STREPTOZOCIN DIABETES; THICK ASCENDING LIMB; ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DRUG EFFECT; EXPERIMENTAL DIABETES MELLITUS; HENLE LOOP; MALE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; FUROSEMIDE; LOOP OF HENLE; MALE; NADPH OXIDASE; OUABAIN; OXYGEN CONSUMPTION; PROTEIN KINASE C-ALPHA; RATS; RATS, SPRAGUE-DAWLEY; SODIUM; SODIUM POTASSIUM CHLORIDE SYMPORTER INHIBITORS; STREPTOZOCIN;

EID: 84856118706     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.111.184796     Document Type: Conference Paper

References (58)

1. Maahs DM, Kinney GL, Wadwa P, Snell-Bergeon JK, Dabelea D, Hokanson J, Ehrlich J, Garg S, Eckel RH, Rewers MJ. Hypertension prevalence, awareness, treatment, and control in an adult type 1 diabetes population and a comparable general population. Diabetes Care. 2005; 28:301-306. (Pubitemid 40170930)
2. Nørgaard K, Feldt-Rasmussen B, Borch-Johnsen K, Saelan H, Deckert T. Prevalence of hypertension in type 1 (insulin-dependent) diabetes mellitus. Diabetologia. 1990;33:407-410. (Pubitemid 20220939)
3. Strojek K, Grzeszczak W, Lacka B, Gorska J, Keller CK, Ritz E. Increased prevalence of salt sensitivity of blood pressure in IDDM with and without microalbuminuria. Diabetologia. 1995;38:1443-1448.
4. Lurbe E, Redon J, Kesani A, Pascual JM, Tacons J, Alvarez V, Batlle D. Increase in nocturnal blood pressure and progression to microalbuminuria in type 1 diabetes. N Engl J Med. 2002;347:797-805. (Pubitemid 34988338)
5. Nørgaard K, Feldt-Rasmussen B. Sodium retention and insulin treatment in insulin-dependent diabetes mellitus. Acta Diabetol. 1994;31:19-25. (Pubitemid 24140473)
6. Feldt-Rasmussen B, Mathiesen ER, Deckert T, Giese J, Christensen NJ, Bent-Hansen L, Nielsen MD. Central role for sodium in the pathogenesis of blood pressure changes independent of angiotensin, aldosterone and catecholamines in type 1 (insulin-dependent) diabetes mellitus. Diabetologia. 1987;30:610-617. (Pubitemid 17139968)
7. Weidmann P, Beretta-Piccoli C, Trost BN. Pressor factors and responsiveness in hypertension accompanying diabetes mellitus. Hypertension. 1985;7:II33-II42.
8. O'Hare JP, Roland JM, Walters G, Corrall RJ. Impaired sodium excretion in response to volume expansion induced by water immersion in insulindependent diabetes mellitus. Clin Sci (Lond). 1986;71:403-409. (Pubitemid 16012439)
9. Roland JM, O'Hare JP, Walters G, Corrall RJ. Sodium retention in response to saline infusion in uncomplicated diabetes mellitus. Diabetes Res. 1986;3:213-215. (Pubitemid 16091033)
10. DiPetrillo K, Coutermarsh B, Soucy N, Hwa J, Gesek F. Tumor necrosis factor induces sodium retention in diabetic rats through sequential effects on distal tubule cells. Kidney Int. 2004;65:1676-1683. (Pubitemid 38591015)
11. Pollock CA, Lawrence JR, Field MJ. Tubular sodium handling and tubuloglomerular feedback in experimental diabetes mellitus. Am J Physiol Renal Fluid Electrolyte Physiol. 1991;260:F946-F952.
12. +- ATPase in diabetes mellitus: Relationship to metabolic abnormality. Am J Physiol Endocrinol Metab. 1993;265:E96-E101. (Pubitemid 23226351)
13. Wald H, Scherzer P, Popovtzer MM. Enhanced renal tubular ouabainsensitive ATPase in streptozotocin diabetes mellitus. Am J Physiol Renal Fluid Electrolyte Physiol. 1986;20:F164-F170.
14. Ku DD, Sellers BM, Meezan E. Development of renal hypertrophy and increased renal Na,K-ATPase in streptozotocin-diabetic rats. Endocrinology. 1986;119:672-679. (Pubitemid 16048823)
15. +- adenosine triphosphatase in streptozotocin-diabetic rats. J Pharmacol Exp Ther. 1984;229:664-670. (Pubitemid 14076396)
16. Baines A, Ho P. Glucose stimulates O2 consumption, NOS, and Na/H exchange in diabetic rat proximal tubules. Am J Physiol Renal Physiol. 2002;283:F286-F293. (Pubitemid 34778991)
17. Khadouri C, Barlet-Bas C, Doucet A. Mechanism of increased tubular Na-K-ATPase during streptozotocin-induced diabetes. Pflugers Arch. 1987;409:296-301. (Pubitemid 17096107)
18. Korner A, Eklof AC, Celsi G, Aperia A. Increased renal metabolism in diabetes: Mechanism and functional implications. Diabetes. 1994;43: 629-633. (Pubitemid 24138773)
19. Yang J, Lane PH, Pollock JS, Carmines PK. PKC-dependent superoxide production by the renal medullary thick ascending limb from diabetic rats. Am J Physiol Renal Physiol. 2009;297:F1220-F1228.
20. Yang J, Lane PH, Pollock JS, Carmines PK. Protein kinase C-dependent NAD(P)H oxidase activation induced by type 1 diabetes in renal medullary thick ascending limb. Hypertension. 2010;55:468-473.
21. Juncos R, Garvin JL. Superoxide enhances Na-K-2Cl cotransporter activity in the thick ascending limb. Am J Physiol Renal Physiol. 2005; 288:F982-F987. (Pubitemid 40569764)
22. + and NO in the thick ascending limb. Hypertension. 2002;39:591-596.
23. + and is diminished by a high-salt diet. Am J Physiol Renal Physiol. 2004;287:F224-F230. (Pubitemid 38943937)
24. Silva GB, Ortiz PA, Hong NJ, Garvin JL. Superoxide stimulates NaCl absorption in the thick ascending limb via activation of protein kinase C. Hypertension. 2006;48:467-472. (Pubitemid 44253742)
25. Silva GB, Garvin JL. Angiotensin II-dependent hypertension increases Na transport-related oxygen consumption by the thick ascending limb. Hypertension. 2008;52:1091-1098.
26. Aristimuño PC, Good DW. PKC isoforms in rat medullary thick ascending limb: Selective activation of the δ isoform by PGE2. Am J Physiol Renal Physiol. 1997;272:F624-F631.
27. Pfaff IL, Wagner HJ, Vallon V. Immunolocalization of protein kinase C isoenzymesα,β1 andβII in rat kidney. J Am Soc Nephrol. 1999;10: 1861-1873. (Pubitemid 29402506)
28. Redling S, Pfaff IL, Leitges M, Vallon V. Immunolocalization of protein kinase C isoenzymesα,βI,βII,δ, andδ in mouse kidney. Am J Physiol Renal Physiol. 2004;287:F289-F298. (Pubitemid 38943946)
29. Fraker C, Timmins MR, Guarino RD, Haaland PD, Ichii H, Molano D, Pileggi A, Poggioli R, Presnell SC, Inverardi L, Zehtab M, Ricordi C. The use of the BD oxygen biosensor system to assess isolated human islets of Langerhans: Oxygen consumption as a potential measure of islet potency. Cell Transplant. 2006;15:745-758. (Pubitemid 46095257)
30. Keenan C, Goode N, Pears C. Isoform specificity of activators and inhibitors of protein kinase Cγandδ. FEBS Lett. 1997;415:101-108. (Pubitemid 27402058)
31. Martiny-Baron G, Kazanietz MG, Mischak H, Blumberg PM, Kochs G, Hug H, Marme D, Schachtele C. Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö6976. J Biol Chem. 1993;268: 9194-9197. (Pubitemid 23145960)
32. Tanaka M, Sagawa S, Hoshi Ji, Shimoma F, Matsuda I, Sakoda K, Sasase T, Shindo M, Inaba T. Synthesis of anilino-monoindolylmaleimides as potent and selective PKCβ inhibitors. Bioorg Med Chem Lett. 2004;14: 5171-5174. (Pubitemid 39233388)
33. Hebert SC, Andreoli TE. Control of NaCl transport in the thick ascending limb. Am J Physiol Renal Fluid Electrolyte Physiol. 1984;246: F745-F756. (Pubitemid 14075683)
34. +-ATPase activity in medullary thick ascending limb during short-term anoxia. Am J Physiol Renal Fluid Electrolyte Physiol. 1987;252:F838-F843.
35. Eveloff J, Bayerdorffer E, Silva P, Kinne R. Sodium-chloride transport in the thick ascending limb of Henle's loop: Oxygen consumption studies in isolated cells. Pflugers Arch. 1981;389:263-270. (Pubitemid 11150178)
36. Chamberlin ME, LeFurgey A, Mandel LJ. Suspension of medullary thick ascending limb tubules from the rabbit kidney. Am J Physiol Renal Fluid Electrolyte Physiol. 1984;247:F955-F964. (Pubitemid 15158555)
37. Palm F, Cederberg J, Hansell P, Liss P, Carlsson PO. Reactive oxygen species cause diabetes-induced decrease in renal oxygen tension. Diabetologia. 2003;46:1153-1160. (Pubitemid 37041246)
38. Palm F. Intrarenal oxygen in diabetes and a possible link to diabetic nephropathy. Clin Exp Pharmacol Physiol. 2006;33:997-1001. (Pubitemid 44427324)
39. Palm F, Hansell P, Ronquist G, Waldenström A, Liss P, Carlsson PO. Polyol-pathway-dependent disturbances in renal medullary metabolism in experimental insulin-deficient diabetes mellitus in rats. Diabetologia. 2004;47:1223-1231. (Pubitemid 39093318)
40. Vallon V, Komers R. Pathophysiology of the diabetic kidney. Compr Physiol. 2011;1:1175-1232.
41. Ortiz PA, Garvin JL. Superoxide stimulates NaCl absorption by the thick ascending limb. Am J Physiol Renal Physiol. 2002;283:F957-F962. (Pubitemid 35192462)
42. Lang F, Görlach A, Vallon V. Targeting SGK1 in diabetes. Expert Opin Ther Targets. 2009;13:1303-1311.
43. Edlund J, Fasching A, Liss P, Hansell P, Palm F. The roles of NADPHoxidase and nNOS for the increased oxidative stress and the oxygen consumption in the diabetic kidney. Diabetes Metab Res Rev. 2010;26: 349-356.
44. +-ATPaseα-subunit in rat kidney cortical tubules. Am J Physiol Cell Physiol. 1996;271:C136-C143.
45. +-ATPase in rat proximal convoluted tubules. Am J Physiol Cell Physiol. 1995;268: C1277-C1283.
46. Féraille E, Béguin P, Carranza ML, Gonin S, Rousselot M, Martin PY, Favre H, Geering K. Is phosphorylation of the δ1 subunit at Ser-16 involved in the control of Na,K-ATPase activity by phorbol ester-activated protein kinase C? Mol Biol Cell. 2000;11:39-50. (Pubitemid 30075504)
47. +-ATPase activity via PKC alpha in rat medullary thick ascending limb. Diabetologia. 2003; 46:124-131. (Pubitemid 36237755)
48. Ridge KM, Dada L, Lecuona E, Bertorello AM, Katz AI, Mochly-Rosen D, Sznajder JI. Dopamine-induced exocytosis of Na,K-ATPase is dependent on activation of protein kinase C-α and -α. Mol Biol Cell. 2002;13:1381-1389. (Pubitemid 34309630)
49. Hoffmann EK, Schettino T, Marshall WS. The role of volume-sensitive ion transport systems in regulation of epithelial transport. Comp Biochem Physiol A Mol Integr Physiol. 2007;148:29-43. (Pubitemid 47077657)
50. Gagnon KB, England R, Delpire E. Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter. Mol Cell Biol. 2006; 26:689-698. (Pubitemid 43089779)
51. Gimenez I. Molecular mechanisms and regulation of furosemide-sensitive Na-K-Cl cotransporters. Curr Opin Nephrol Hypertens. 2006;15: 517-523.
52. Richardson C, Alessi DR. The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway. J Cell Sci. 2008; 121:3293-3304.
53. + acts upstream of SPAK in the activation of NKCC1 by hyperosmotic stress in human airway epithelial cells. J Biol Chem. 2008;283:22147-22156.
54. Kim D, Sands JM, Klein JD. Changes in renal medullary transport proteins during uncontrolled diabetes mellitus in rats. Am J Physiol Renal Physiol. 2003;285:F303-F309. (Pubitemid 36871203)
55. Nejsum LN, Kwon T-H, Marples D, Flyvbjerg A, Knepper MA, Frøkiaer J, Nielsen S. Compensatory increase in AQP2, p-AQP2, and AQP3 expression in rats with diabetes mellitus. Am J Physiol Renal Physiol. 2001;280:F715-F726.
56. +-ATPaseα1- andβ1-subunits in diabetic rat kidneys using RT-PCR. Am J Physiol Renal Physiol. 2002;282:F492-F500. (Pubitemid 34654539)
57. Patel KP. Volume reflex in diabetes. Cardiovasc Res. 1997;34:81-90. (Pubitemid 27261916)
58. Singh DK, Winocour P, Farrington K. Mechanisms of disease: The hypoxic tubular hypothesis of diabetic nephropathy. Nat Clin Pract Nephrol. 2008;4:216-226. (Pubitemid 351451302)