A novel and versatile computational tool to model translation

Bioinformatics

Volumn 28, Issue 2, 2012, Pages 292-293

  Chu, Dominique ^a   Zabet, Nicolae ^b   von der Haar, Tobias ^a  

^a UNIVERSITY OF KENT   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; TRANSFER RNA;

ARTICLE; CODON; COMPUTER PROGRAM; METABOLISM; OPEN READING FRAME; PROTEIN SYNTHESIS; RIBOSOME;

CODON; OPEN READING FRAMES; PROTEIN BIOSYNTHESIS; RIBOSOMES; RNA, MESSENGER; RNA, TRANSFER; SOFTWARE;

EID: 84856117068     PISSN: 13674803     EISSN: 14602059     Source Type: Journal    
DOI: 10.1093/bioinformatics/btr650     Document Type: Article

References (8)

1. Chu,D. et al. (2011) The role of tRNA and ribosome competition in coupling the expression of different mRNAs in saccharomyces cerevisiae. Nucleic Acids Res., 39, 6705-6714.
2. Fluitt,A. et al. (2007) Ribosome kinetics and aa-trna competition determine rate and delity of peptide synthesis. Comput. Biol. Chem., 31, 335-346.
3. Gillespie,D.T. (1977) Exact stochastic simulation of coupled chemical reactions. J. Phy. Chem., 81, 2340-2361.
4. Gromadski,K. and Rodnina,M. (2004) Kinetic determinants of high-delity trna discrimination on the ribosome. Mol. Cell, 13, 191-200.
5. Reuveni,S. et al. (2011) Genome-scale analysis of translation elongation with a ribosome ow model. PLoS Comput. Biol., 7, e1002127.
6. Romano,M. et al. (2009) Queueing phase transition: theory of translation. Phy. Rev. Lett., 102, 198104.
7. von der Haar,T. and McCarthy,J. (2002) Intracellular translation initiation factor levels in saccharomyces cerevisiae and their role in cap-complex function. Mol. Microbiol., 46, 531-544.
8. Zouridis,H. and Hatzimanikatis,V. (2007) A model for protein translation: polysome self-organization leads to maximum protein synthesis rates. Biophys. J., 92, 717-730.