Comparative investigation of IV iohexol and iopamidol: Effect on renal function in low-risk outpatients undergoing CT

American Journal of Roentgenology

Volumn 198, Issue 2, 2012, Pages 392-397

  Dillman, Jonathan R ^a   Al Hawary, Mahmoud ^a   Ellis, James H ^a   Cohan, Richard H ^a   Kaza, Ravi ^a   Myles, James D ^b   Khalatbari, Shokoufeh ^b   Francis, Isaac R ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Comparative study; Contrast induced nephrotoxicity; CT; Iohexol; Iopamidol

Indexed keywords

CREATININE; IOHEXOL; IOPAMIDOL; CONTRAST MEDIUM;

ADULT; ARTICLE; BODY MASS; COMPARATIVE STUDY; COMPUTER ASSISTED TOMOGRAPHY; CONTRAST INDUCED NEPHROPATHY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; GLOMERULUS FILTRATION RATE; HUMAN; KIDNEY FUNCTION; MAJOR CLINICAL STUDY; MALE; OUTPATIENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; SIDE EFFECT; CHEMICALLY INDUCED DISORDER; CHI SQUARE DISTRIBUTION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY DISEASE; KIDNEY FUNCTION TEST; MIDDLE AGED;

CHI-SQUARE DISTRIBUTION; CONTRAST MEDIA; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INJECTIONS, INTRAVENOUS; IOHEXOL; IOPAMIDOL; KIDNEY DISEASES; KIDNEY FUNCTION TESTS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84856115642     PISSN: 0361803X     EISSN: 15463141     Source Type: Journal    
DOI: 10.2214/AJR.11.6993     Document Type: Article

References (23)

1. Stacul F. Currently available iodinated contrast media. In: Thomsen HS, Muller RN, Mattrey RF, eds. Trends in contrast media. Berlin, Germany: Springer-Verlag, 1999:63-80
2. Sharma SK, Kini A. Effect of nonionic radiocontrast agents on the occurrence of contrast-induced nephropathy in patients with mild-moderate chronic renal insufficiency: pooled analysis of the randomized trials. Catheter Cardiovasc Interv 2005; 65:386-393 (Pubitemid 40898183)
3. Solomon R, Dumouchel W. Contrast media and nephropathy: findings from systematic analysis and Food and Drug Administration reports of adverse effects. Invest Radiol 2006; 41:651-660 (Pubitemid 44284174)
4. Berrington de González A, Mahesh M, Kim KP, et al. Projected cancer risks from computed tomographic scans performed in the United States in 2007. Arch Intern Med 2009; 169:2071-2077
5. Ellis JH, Cohan RH. Reducing the risk of contrast-induced nephropathy: a perspective on the controversies. AJR 2009; 192:1544-1549
6. Levey AS, Coresh J, Greene T, et al. Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann Intern Med 2006; 145:247-254 (Pubitemid 46768608)
7. Heinrich MC, Häberle L, Müller V, Bautz W, Uder M. Nephrotoxicity of iso-osmolar iodixanol compared with nonionic low-osmolar contrast media: meta-analysis of randomized controlled trials. Radiology 2009; 250:68-86
8. Kuhn MJ, Chen N, Sahani DV, et al. The PREDICT study: a randomized double-blind comparison of contrast-induced nephropathy after low- or isoosmolar contrast agent exposure. AJR 2008; 191:151-157 (Pubitemid 351955220)
9. Solomon RJ, Natarajan MK, Doucet S, et al.; Investigators of the CARE Study. Cardiac Angiography in Renally Impaired Patients (CARE) study: a randomized double-blind trial of contrast-induced nephropathy in patients with chronic kidney disease. Circulation 2007; 115:3189-3196 (Pubitemid 47012233)
10. Weisbord SD, Mor MK, Resnick AL, Hartwig KC, Palevsky PM, Fine MJ. Incidence and outcomes of contrast-induced AKI following computed tomography. Clin J Am Soc Nephrol 2008; 3:1274-1281
11. Aspelin P, Aubry P, Fransson S, Strasser R, Willenbrock R, Berg KJ. Nephrotoxic effects in highrisk patients undergoing angiography. N Engl J Med 2003; 348:491-499 (Pubitemid 36159884)
12. Solomon RJ, Mehran R, Natarajan MK, et al. Contrast-induced nephropathy and long-term adverse events: cause and effect? Clin J Am Soc Nephrol 2009; 4:1162-1169
13. Mehta RL, Kellum JA, Shah SV, et al. Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care 2007; 11:R31
14. Kaul S, Diamond GA. Good enough: a primer on the analysis and interpretation of noninferiority trials. Ann Intern Med 2006; 145:62-69 (Pubitemid 46780603)
15. Verma M, Khdapkar R, Soumyaranjan S, Das BR. Comparing age-wise reference intervals for serum creatinine concentration in a "reality check" of the recommended cut-off. Ind J Clin Biochem 2006; 21:90-94 (Pubitemid 44756931)
16. European Agency for the Evaluation of Medicinal Products Website. Points to consider on switching between superiority and non-inferiority. http://www.tga.gov.au/pdf/euguide/ewp048299en.pdf. Published July 27, 2000. Accessed December 31, 2010
17. Lan KKG, DeMets DL. Discrete sequential boundaries for clinical trials. Biometrika 1983; 70:659-663
18. Newhouse JH, Kho D, Rao QA, Starren J. Frequency of serum creatinine changes in the absence of iodinated contrast material: implications for studies of contrast nephrotoxicity. AJR 2008; 191:376-382
19. Baumgarten DA, Ellis JH. Contrast-induced nephropathy: contrast material not required? AJR 2008; 191:383-386
20. Nash K, Hafeez A, Hou S. Hospital-acquired renal insufficiency. Am J Kidney Dis 2002; 39:930-936 (Pubitemid 34454211)
21. From AM, Bartholmai BJ, Williams AW, Cha SS, McDonald FS. Mortality associated with nephropathy after radiographic contrast exposure. Mayo Clin Proc 2008; 83:1095-1100
22. Thomsen HS. Nephrotoxicity. In: Thomsen HS, Muller RN, Mattrey RF, eds. Trends in contrast media. Berlin, Germany: Springer-Verlag, 1999:103-116
23. Bräutigam M, Persson PB. Do iodinated contrast media interfere with renal tubular creatinine secretion? (letter) Radiology 2006; 240:615 (Pubitemid 44098668)