Transferrin antibodies into the brain

Neuropsychopharmacology

Volumn 37, Issue 1, 2012, Pages 302-303

  Dennis, Mark S ^a   Watts, Ryan J ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA SECRETASE 1 ANTIBODY; ENZYME ANTIBODY; PROTEIN ANTIBODY; TRANSFERRIN ANTIBODY; UNCLASSIFIED DRUG;

ANTIBODY AFFINITY; ANTIBODY ENGINEERING; ANTIBODY PRODUCTION; BLOOD BRAIN BARRIER; DRUG DISTRIBUTION; DRUG UPTAKE; NEUROPHARMACOLOGY; NOTE; PRIORITY JOURNAL; RECEPTOR MEDIATED TRANSCYTOSIS; TRANSCYTOSIS;

ANIMALS; ANTIBODIES; BLOOD-BRAIN BARRIER; BRAIN DISEASES; DRUG DELIVERY SYSTEMS; HUMANS; RECEPTORS, TRANSFERRIN; TRANSCYTOSIS; TRANSFERRIN;

EID: 84856111923     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2011.196     Document Type: Note

References (6)

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3. Friden PM, Walus LR, Musso GF, Taylor MA, Malfroy B, Starzyk RM (1991). Anti-transferrin receptor antibody and antibody-drug conjugates cross the blood-brain barrier. Proc Natl Acad Sci USA 88: 4771.
4. Jones AR, Shusta EV (2007). Blood-brain barrier transport of therapeutics via receptor mediation. Pharm Res 24: 1759.
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6. Yu YJ, Zhang Y, Kenrick M, Hoyte K, Luk W, Lu Y et al (2011). Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target. Sci Transl Med 3: 84ra44.