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Volumn 742, Issue 1-2, 2012, Pages 72-78

Genotoxicity of furan in Big Blue rats

Author keywords

Cancer mode of action; Comet assay; Hprt mutation; Micronucleus assay; Pig a mutation

Indexed keywords

CELL PROTEIN; FURAN; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; PIG A PROTEIN; UNCLASSIFIED DRUG;

EID: 84856111191     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2011.12.011     Document Type: Article
Times cited : (51)

References (53)
  • 2
    • 84856106459 scopus 로고    scopus 로고
    • U.S. FDA (U.S. Food and Drug Administration), Exploratory Data on Furan in Food, Data Through April 28, (accessed 8-21-2011).
    • U.S. FDA (U.S. Food and Drug Administration), Exploratory Data on Furan in Food, Data Through April 28, 2004, (accessed 8-21-2011). http://www.fda.gov/ohrms/dockets/ac/04/briefing/4045b2_09_furan%20data.pdf.
    • (2004)
  • 3
    • 84856083506 scopus 로고    scopus 로고
    • U.S. FDA (U.S. Food and Drug Administration), Exploratory Data on Furan in Food: Individual Food Products, Data Through September 17, (site accessed 8-3-2011).
    • U.S. FDA (U.S. Food and Drug Administration), Exploratory Data on Furan in Food: Individual Food Products, Data Through September 17, 2008, (site accessed 8-3-2011). http://www.fda.gov/Food/FoodSafety/FoodContaminantsAdulteration/ChemicalContaminants/Furan/ucm078439.htm.
    • (2008)
  • 4
    • 0011208536 scopus 로고
    • Toxicology and Carcinogenesis Studies of Furan (CAS No. 110-00-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies), in: NTP Technical Report Series No. 402, NTP, Research Triangle Park, NC
    • NTP (National Toxicology Program), Toxicology and Carcinogenesis Studies of Furan (CAS No. 110-00-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies), in: NTP Technical Report Series No. 402, NTP, Research Triangle Park, NC, 1993, pp. 1-287.
    • (1993) NTP (National Toxicology Program) , pp. 1-287
  • 5
    • 0030670353 scopus 로고    scopus 로고
    • Extrapolation of in vitro enzyme induction data to humans in vivo
    • Kedderis G.L. Extrapolation of in vitro enzyme induction data to humans in vivo. Chem.-Biol. Interact. 1997, 107:109-121.
    • (1997) Chem.-Biol. Interact. , vol.107 , pp. 109-121
    • Kedderis, G.L.1
  • 7
    • 0028785113 scopus 로고
    • Identification of cis-2-butene-1,4-dial as a microsomal metabolite of furan
    • Chen L.-J., Hecht S.S., Peterson L.A. Identification of cis-2-butene-1,4-dial as a microsomal metabolite of furan. Chem. Res. Toxicol. 1995, 8:903-906.
    • (1995) Chem. Res. Toxicol. , vol.8 , pp. 903-906
    • Chen, L.-J.1    Hecht, S.S.2    Peterson, L.A.3
  • 8
    • 0036129082 scopus 로고    scopus 로고
    • Characterization of nucleoside adducts of cis-2-butene-1,4-dial, a reactive metabolite of furan
    • Byrns M.C., Predecki D.P., Peterson L.A. Characterization of nucleoside adducts of cis-2-butene-1,4-dial, a reactive metabolite of furan. Chem. Res. Toxicol. 2002, 15:373-379.
    • (2002) Chem. Res. Toxicol. , vol.15 , pp. 373-379
    • Byrns, M.C.1    Predecki, D.P.2    Peterson, L.A.3
  • 9
    • 10844243981 scopus 로고    scopus 로고
    • 2-etheno-2'-deoxyguanosine adducts by cis-2-butene-1,4-dial, a reactive metabolite of furan
    • 2-etheno-2'-deoxyguanosine adducts by cis-2-butene-1,4-dial, a reactive metabolite of furan. Chem. Res. Toxicol. 2004, 17:1607-1613.
    • (2004) Chem. Res. Toxicol. , vol.17 , pp. 1607-1613
    • Byrns, M.C.1    Vu, C.C.2    Peterson, L.A.3
  • 10
    • 0033914808 scopus 로고    scopus 로고
    • A reactive metabolite of furan, cis-2-butene-1,4-dial, is mutagenic in the Ames assay
    • Peterson L.A., Naruko K.C., Predecki D.P. A reactive metabolite of furan, cis-2-butene-1,4-dial, is mutagenic in the Ames assay. Chem. Res. Toxicol. 2000, 13:531-534.
    • (2000) Chem. Res. Toxicol. , vol.13 , pp. 531-534
    • Peterson, L.A.1    Naruko, K.C.2    Predecki, D.P.3
  • 12
    • 33845432139 scopus 로고    scopus 로고
    • Electrophilic intermediates produced by bioactivation of furan
    • Peterson L.A. Electrophilic intermediates produced by bioactivation of furan. Drug Metab. Rev. 2006, 38:615-626.
    • (2006) Drug Metab. Rev. , vol.38 , pp. 615-626
    • Peterson, L.A.1
  • 13
    • 0022458177 scopus 로고
    • Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals
    • Mortelmans K., Haworth S., Lawlor T., Speck W., Tainer B., Zeiger E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals. Environ. Mutagen. 1986, 8(Suppl 7):1-119.
    • (1986) Environ. Mutagen. , vol.8 , Issue.SUPPL. 7 , pp. 1-119
    • Mortelmans, K.1    Haworth, S.2    Lawlor, T.3    Speck, W.4    Tainer, B.5    Zeiger, E.6
  • 16
    • 12744258127 scopus 로고    scopus 로고
    • V79-hCYP2E1-hSULT1A1, a cell line for the sensitive detection of genotoxic effects induced by carbohydrate pyrolysis products and other food-borne chemicals
    • Glatt H., Schneider H., Liu Y. V79-hCYP2E1-hSULT1A1, a cell line for the sensitive detection of genotoxic effects induced by carbohydrate pyrolysis products and other food-borne chemicals. Mutat. Res. 2005, 580:41-52.
    • (2005) Mutat. Res. , vol.580 , pp. 41-52
    • Glatt, H.1    Schneider, H.2    Liu, Y.3
  • 17
    • 33846817437 scopus 로고    scopus 로고
    • Furan is not genotoxic in the micronucleus assay in vivo or in vitro
    • Durling L.J.K., Svensson K., Abramsson-Zetterberg L. Furan is not genotoxic in the micronucleus assay in vivo or in vitro. Toxicol. Ltt. 2007, 169:43-50.
    • (2007) Toxicol. Ltt. , vol.169 , pp. 43-50
    • Durling, L.J.K.1    Svensson, K.2    Abramsson-Zetterberg, L.3
  • 18
    • 33846193238 scopus 로고    scopus 로고
    • Report of the IWGT working group on strategy/interpretation for regulatory in vivo tests. II. Identification of in vivo-only positive compounds in the bone marrow micronucleus test
    • Tweats D.J., Blakey D., Heflich R.H., Jacobs A., Jacobsen S.D., Morita T., Nohmi T., O'Donovan M.R., Sasaki Y.F., Sofuni T., Tice R. Report of the IWGT working group on strategy/interpretation for regulatory in vivo tests. II. Identification of in vivo-only positive compounds in the bone marrow micronucleus test. Mutat. Res. 2007, 627:92-105.
    • (2007) Mutat. Res. , vol.627 , pp. 92-105
    • Tweats, D.J.1    Blakey, D.2    Heflich, R.H.3    Jacobs, A.4    Jacobsen, S.D.5    Morita, T.6    Nohmi, T.7    O'Donovan, M.R.8    Sasaki, Y.F.9    Sofuni, T.10    Tice, R.11
  • 21
    • 0026603074 scopus 로고
    • Evaluation of genotoxicity, pathological lesions, and cell proliferation in livers of rats and mice treated with furan
    • Wilson D.M., Goldsworthy T.L., Popp J.A., Butterworth B.E. Evaluation of genotoxicity, pathological lesions, and cell proliferation in livers of rats and mice treated with furan. Environ. Mol. Mutagen. 1992, 19:209-222.
    • (1992) Environ. Mol. Mutagen. , vol.19 , pp. 209-222
    • Wilson, D.M.1    Goldsworthy, T.L.2    Popp, J.A.3    Butterworth, B.E.4
  • 23
    • 73649144555 scopus 로고    scopus 로고
    • Assessment of in vivo genotoxicity of the rodent carcinogen furan: evaluation of DNA damage and induction of micronuclei in mouse splenocytes
    • Leopardi P., Cordelli E., Villani P., Cremona T.P., Conti L., De Luca G., Crebelli R. Assessment of in vivo genotoxicity of the rodent carcinogen furan: evaluation of DNA damage and induction of micronuclei in mouse splenocytes. Mutagenesis 2010, 25:57-62.
    • (2010) Mutagenesis , vol.25 , pp. 57-62
    • Leopardi, P.1    Cordelli, E.2    Villani, P.3    Cremona, T.P.4    Conti, L.5    De Luca, G.6    Crebelli, R.7
  • 26
    • 77952538111 scopus 로고    scopus 로고
    • Evidence of oxidative stress and associated DNA damage, increased proliferative drive, and altered gene expression in rat liver produced by the cholangiocarcinogenic agent furan
    • Hickling K.C., Hitchcock J.M., Oreffo V., Mally A., Hammond T.G., Evans J.G., Chipman J.K. Evidence of oxidative stress and associated DNA damage, increased proliferative drive, and altered gene expression in rat liver produced by the cholangiocarcinogenic agent furan. Toxicol. Pathol. 2010, 38:230-243.
    • (2010) Toxicol. Pathol. , vol.38 , pp. 230-243
    • Hickling, K.C.1    Hitchcock, J.M.2    Oreffo, V.3    Mally, A.4    Hammond, T.G.5    Evans, J.G.6    Chipman, J.K.7
  • 27
    • 77952497141 scopus 로고    scopus 로고
    • Induction and progression of cholangiofibrosis in rat liver injured by oral administration of furan
    • Hickling K.C., Hitchcock J.M., Chipman J.K., Hammond T.G., Evans J.G. Induction and progression of cholangiofibrosis in rat liver injured by oral administration of furan. Toxicol. Pathol. 2010, 38:213-219.
    • (2010) Toxicol. Pathol. , vol.38 , pp. 213-219
    • Hickling, K.C.1    Hitchcock, J.M.2    Chipman, J.K.3    Hammond, T.G.4    Evans, J.G.5
  • 28
    • 77249096480 scopus 로고    scopus 로고
    • Flow cytometric detection of Pig-A mutant red blood cells using an erythroid-specific antibody: application of the method for evaluating the in vivo genotoxicity of methylphenidate in adolescent rats
    • Dobrovolsky V.N., Boctor S.Y., Twaddle N.C., Doerge D.R., Bishop M.E., Manjanatha M.G., Kimoto T., Miura D., Heflich R.H., Ferguson S.A. Flow cytometric detection of Pig-A mutant red blood cells using an erythroid-specific antibody: application of the method for evaluating the in vivo genotoxicity of methylphenidate in adolescent rats. Environ. Mol. Mutagen. 2010, 51:138-145.
    • (2010) Environ. Mol. Mutagen. , vol.51 , pp. 138-145
    • Dobrovolsky, V.N.1    Boctor, S.Y.2    Twaddle, N.C.3    Doerge, D.R.4    Bishop, M.E.5    Manjanatha, M.G.6    Kimoto, T.7    Miura, D.8    Heflich, R.H.9    Ferguson, S.A.10
  • 30
    • 16644381712 scopus 로고    scopus 로고
    • Analysis of in vivo mutation in the Hprt and Tk genes of mouse lymphocytes
    • Dobrovolsky V.N., Shaddock J.G., Heflich R.H. Analysis of in vivo mutation in the Hprt and Tk genes of mouse lymphocytes. Methods Mol. Biol. 2005, 291:133-144.
    • (2005) Methods Mol. Biol. , vol.291 , pp. 133-144
    • Dobrovolsky, V.N.1    Shaddock, J.G.2    Heflich, R.H.3
  • 32
    • 0023919963 scopus 로고
    • A simple technique for quantitation of low levels of DNA damage in individual cells
    • Singh N.P., McCoy M.T., Tice R.R., Schneider E.L. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 1988, 175:184-191.
    • (1988) Exp. Cell Res. , vol.175 , pp. 184-191
    • Singh, N.P.1    McCoy, M.T.2    Tice, R.R.3    Schneider, E.L.4
  • 34
    • 84856115336 scopus 로고    scopus 로고
    • Sixth Framework Programme, SSPE-CT-2006-44393: Role of Genetic and Non-Genetic Mechanisms in Furan Risk, (site accessed 8-20-11).
    • Sixth Framework Programme, SSPE-CT-2006-44393: Role of Genetic and Non-Genetic Mechanisms in Furan Risk, 2009, (site accessed 8-20-11). http://www.furan-ra.toxi.uni-wuerzburg.de/uploads/media/D8.2-Database.pdf.
    • (2009)
  • 35
    • 84856106460 scopus 로고    scopus 로고
    • U.S. FDA/NCTR (U.S. Food and Drug Administration/National Center for Toxicological Research), National Center for Toxicological Research Annual Report (site accessed 8-20-11).
    • U.S. FDA/NCTR (U.S. Food and Drug Administration/National Center for Toxicological Research), National Center for Toxicological Research Annual Report 2009-2010, (site accessed 8-20-11). http://www.fda.gov/downloads/aboutfda/centersoffices/nctr/researchaccomplishmentsplans/ucm200349.pdf.
    • (2009)
  • 37
    • 84856106461 scopus 로고    scopus 로고
    • U.S. EPA (U.S. Environmental Protection Agency), Guidelines for Carcinogen Risk Assessment, EPA/630/P-03/001B, March (accessed 9-22-11).
    • U.S. EPA (U.S. Environmental Protection Agency), Guidelines for Carcinogen Risk Assessment, EPA/630/P-03/001B, March 2005, (accessed 9-22-11). http://www.epa.gov/ttnatw01/cancer_guidelines_final_3-25-05.pdf.
    • (2005)
  • 38
    • 84856106462 scopus 로고    scopus 로고
    • U.S. EPA (U.S. Environmental Protection Agency), Supplemental Guidance for Assessing Susceptibility from Early-Life Exposure to Cancinogens, EPA/630R-03/003F, March (accessed 9-22-11).
    • U.S. EPA (U.S. Environmental Protection Agency), Supplemental Guidance for Assessing Susceptibility from Early-Life Exposure to Cancinogens, EPA/630R-03/003F, March 2005, (accessed 9-22-11). http://www.epa.gov/ttn/atw/childrens_supplement_final.pdf.
    • (2005)
  • 39
  • 40
    • 84856107263 scopus 로고    scopus 로고
    • EFSA (European Food Safety Authority), Report of the Scientific Panel on Contaminants in the Food Chain on Provisional Findings on Furan in Food (Question No. EFSA-Q-2004-109), EFSA J. 137 (2004) 1-20.
    • EFSA (European Food Safety Authority), Report of the Scientific Panel on Contaminants in the Food Chain on Provisional Findings on Furan in Food (Question No. EFSA-Q-2004-109), EFSA J. 137 (2004) 1-20.
  • 41
    • 34547871290 scopus 로고    scopus 로고
    • Data requirements for risk assessment of furan in food
    • Heppner C.W., Schlatter J.R. Data requirements for risk assessment of furan in food. Food Additives Contaminants 2007, 24(Suppl 1):114-121.
    • (2007) Food Additives Contaminants , vol.24 , Issue.SUPPL. 1 , pp. 114-121
    • Heppner, C.W.1    Schlatter, J.R.2
  • 42
    • 0027377274 scopus 로고
    • Furan-induced cytolethality in isolated rat hepatocytes: correspondence with in vivo dosimetry
    • Carfagna M.A., Held S.D., Kedderis G.L. Furan-induced cytolethality in isolated rat hepatocytes: correspondence with in vivo dosimetry. Toxicol. Appl. Pharmacol. 1993, 123:265-273.
    • (1993) Toxicol. Appl. Pharmacol. , vol.123 , pp. 265-273
    • Carfagna, M.A.1    Held, S.D.2    Kedderis, G.L.3
  • 43
    • 60849118640 scopus 로고    scopus 로고
    • Furan-induced dose-response relationships for liver cytotoxicity, cell proliferation, and tumorigenicity (furan-induced liver tumorigenicity)
    • Moser G.J., Foley J., Burnett M., Goldsworthy T.L., Maronpot R. Furan-induced dose-response relationships for liver cytotoxicity, cell proliferation, and tumorigenicity (furan-induced liver tumorigenicity). Exp. Toxicol. Pathol. 2009, 61:101-111.
    • (2009) Exp. Toxicol. Pathol. , vol.61 , pp. 101-111
    • Moser, G.J.1    Foley, J.2    Burnett, M.3    Goldsworthy, T.L.4    Maronpot, R.5
  • 46
    • 0033402830 scopus 로고    scopus 로고
    • Relationships between exposure, cell loss and proliferation, and manifestation of Hprt mutant T cells following treatment of preweanling, weanling, and adult male mice with N-ethyl-N-nitrosourea
    • Walker V.E., Jones I.M., Crippen T.L., Meng Q., Walker D.M., Bauer M.J., Reilly A.A., Tates A.D., Nakamura J., Upton P.B., Skopek T.R. Relationships between exposure, cell loss and proliferation, and manifestation of Hprt mutant T cells following treatment of preweanling, weanling, and adult male mice with N-ethyl-N-nitrosourea. Mutat. Res. 1999, 431:371-388.
    • (1999) Mutat. Res. , vol.431 , pp. 371-388
    • Walker, V.E.1    Jones, I.M.2    Crippen, T.L.3    Meng, Q.4    Walker, D.M.5    Bauer, M.J.6    Reilly, A.A.7    Tates, A.D.8    Nakamura, J.9    Upton, P.B.10    Skopek, T.R.11
  • 47
    • 67650021207 scopus 로고    scopus 로고
    • Accumulation and persistence of Pig-A mutant peripheral red blood cells following treatment of rats with single and split doses of N-ethyl-N-nitrosourea
    • Miura D., Dobrovolsky V.N., Kimoto T., Kasahara Y., Heflich R.H. Accumulation and persistence of Pig-A mutant peripheral red blood cells following treatment of rats with single and split doses of N-ethyl-N-nitrosourea. Mutat. Res. 2009, 677:86-92.
    • (2009) Mutat. Res. , vol.677 , pp. 86-92
    • Miura, D.1    Dobrovolsky, V.N.2    Kimoto, T.3    Kasahara, Y.4    Heflich, R.H.5
  • 48
    • 79957842103 scopus 로고    scopus 로고
    • Manifestation of Pig-a mutant bone marrow erythroids and peripheral blood erythrocytes in mice treated with N-ethyl-N-nitrosourea: direct sequencing of Pig-a cDNA from bone marrow cells negative for GPI-anchored protein expression
    • Kimoto T., Suzuki K., X.m.Kobayashi, Dobrovolsky V.N., Heflich R.H., Miura D., Kasahara Y. Manifestation of Pig-a mutant bone marrow erythroids and peripheral blood erythrocytes in mice treated with N-ethyl-N-nitrosourea: direct sequencing of Pig-a cDNA from bone marrow cells negative for GPI-anchored protein expression. Mutat. Res. 2011, 723:36-42.
    • (2011) Mutat. Res. , vol.723 , pp. 36-42
    • Kimoto, T.1    Suzuki, K.2    Kobayashi, X.M.3    Dobrovolsky, V.N.4    Heflich, R.H.5    Miura, D.6    Kasahara, Y.7
  • 49
    • 0027397165 scopus 로고
    • The effect of time after treatment, treatment schedule and animal age on the frequency of 6-thioguanine-resistant T-lymphocytes induced in Fischer 344 rats by N-ethyl-N-nitrosourea
    • Aidoo A., Lyn-Cook L.E., Heflich R.H., George E.O., Casciano D.A. The effect of time after treatment, treatment schedule and animal age on the frequency of 6-thioguanine-resistant T-lymphocytes induced in Fischer 344 rats by N-ethyl-N-nitrosourea. Mutat. Res. 1993, 298:169-178.
    • (1993) Mutat. Res. , vol.298 , pp. 169-178
    • Aidoo, A.1    Lyn-Cook, L.E.2    Heflich, R.H.3    George, E.O.4    Casciano, D.A.5
  • 53
    • 84856115335 scopus 로고    scopus 로고
    • Genotoxity of furan in F344 rats using the in vivo Comet and micronucleus assays, The Toxicologist, Supplement to Toxicological Sciences , PS 1548, (accessed 12-5-11).
    • W. Ding, R.H. Heflich, M.G. Pearce, G. White, R.A. Mittelstaedt, J.G. Shaddock, P.L. McDaniel, D.R. Doerge, M.G. Manjanatha, A. Aidoo, Genotoxity of furan in F344 rats using the in vivo Comet and micronucleus assays, The Toxicologist, Supplement to Toxicological Sciences (2011) p. 332, PS 1548, (accessed 12-5-11). http://www.toxicology.org/AI/PUB/Toxicologist11.pdf.
    • (2011) , pp. 332
    • Ding, W.1    Heflich, R.H.2    Pearce, M.G.3    White, G.4    Mittelstaedt, R.A.5    Shaddock, J.G.6    McDaniel, P.L.7    Doerge, D.R.8    Manjanatha, M.G.9    Aidoo, A.10


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