Role of luteinizing hormone β-subunit gene variants among South Indian women with polycystic ovary syndrome

Gene

Volumn 494, Issue 1, 2012, Pages 51-56

  Dasgupta, Shilpi ^a   Sirisha, P V S ^a   Neelaveni, K ^b   Anuradha, K ^c   Sudhakar, G ^d   Reddy, B Mohan ^a  

^a INDIAN STATISTICAL INSTITUTE   (India)

^b OSMANIA GENERAL HOSPITAL   (India)

^c Anu Test Tube Baby Centre   (India)

^d ANDHRA UNIVERSITY   (India)

Author keywords

India; Luteinizing hormone subunit; Mutation; PCOS

Indexed keywords

FOLLITROPIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LUTEINIZING HORMONE; LUTEINIZING HORMONE BETA SUBUNIT; TESTOSTERONE; TRIACYLGLYCEROL;

ADOLESCENT; ADULT; ARTICLE; BODY MASS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; EXON; FEMALE; FOLLITROPIN BLOOD LEVEL; GENE FREQUENCY; GENE MUTATION; GENETIC HETEROGENEITY; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; HYPOPHYSIS GONAD SYSTEM; INDIAN; LUTEINIZING HORMONE BLOOD LEVEL; LUTEINIZING HORMONE RELEASE; MAJOR CLINICAL STUDY; MENARCHE; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TESTOSTERONE BLOOD LEVEL; TRIACYLGLYCEROL BLOOD LEVEL;

ADOLESCENT; ADULT; CASE-CONTROL STUDIES; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; INDIA; LINKAGE DISEQUILIBRIUM; LUTEINIZING HORMONE; MIDDLE AGED; MUTATION; POLYCYSTIC OVARY SYNDROME; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN SUBUNITS;

EID: 84856105625     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2011.11.054     Document Type: Article

References (19)

1. Dasgupta S., et al. Androgen receptor CAG repeat polymorphism and epigenetic influence among the South Indian women with polycystic ovary syndrome. PLoS One 2010, 5:e12401.
2. Elter K., Erel C.T., Cine N., Ozbek U., Hacihanefioglu B., Ertungealp E. Role of the mutations Trp8=>Arg and Ile15=>Thr of the human luteinizing hormone beta-subunit in women with polycystic ovary syndrome. Fertil. Steril. 1999, 71:425-430.
3. Furui K., et al. Identification of two point mutation in the gene coding luteinizing hormone (LH) β subunit associated with immunologically anomalous LH variant. J. Clin. Endocrinol. Metab. 1994, 78:107-113.
4. Haavisto A., Pettersson K., Bergendahl M., Virkah'lkki A., Huhtaniemi I. Occurrence and biological properties of a common genetic variant of luteinizing hormone. J. Clin. Endocrinol. Metab. 1995, 80:1257-1263.
5. Huhtaniemi I., Jiang M., Nilsson C., Pettersson K. Mutations and polymorphisms in gonadotropin genes. Mol. Cell. Endocrinol. 1999, 51:89-94.
6. Liao W.X., Roy A.C., Chan C., Arulkumaran S., Ratnam S.S. A new molecular variant of luteinizing hormone associated with female infertility. Fertil. Steril. 1998, 69:102-106.
7. Marshall J.C., Eagleson C.A., McCartney C.R. Neuroendocrine dysfunction in polycystic ovary syndrome. Polycystic Ovary Syndrome 2002, 89-103. Marcel Dekker Inc., New York. R.J. Chang, J.J. Heindel, A. Dunaif (Eds.).
8. Mifsud A., Ramirez S., Yong E.L. Androgen receptor gene CAG trinucleotide repeats in anovulatory infertility and polycystic ovaries. J. Clin. Endocrinol. Metab. 2000, 85:3484-3488.
9. Nilsson C., Pettersson K., Millar R.P., Coerver K.A., Matzuk M.M., Huhtaniemi I.T. Worldwide frequency of a common genetic variant of luteinizing hormone: an international collaborative research. Fertil. Steril. 1997, 67:998-1004.
10. Pettersson K., Makela M.M., Dahlen P., Lamminen T., Huoponen K., Huhtaniemi I. Gene polymorphism found in the LH beta gene of an immunologically anomalous variant of human luteinizing hormone. Eur. J. Endocrinol. 1994, 130:S17.03. (abstract).
11. Rajkhowa M., et al. Prevalence of an immunological LH β-subunit variant in a UK population of healthy women and women with polycystic ovary syndrome. Clin. Endocrinol. 1995, 43:297-303.
12. Ramanujam L.N., Liao W.X., Roy A.C., Loganath A., Goh H.H., Ng S.C. Association of molecular variants of luteinizing hormone with menstrual disorders. Clin. Endocrinol. 1999, 51:243-246.
13. Reddy B.M., Naidu V.M., Madhavi V.K., Thangaraj K., Kumar V. Microsatellite diversity in Andhra Pradesh, India: genetic stratification versus social stratification. Hum. Biol. 2005, 77:803-823.
14. Roy A.C., Liao W.X., Chen Y., Arulkumaran S., Ratnam S.S. Identification of seven novel mutations in LH β -subunit genes by SSCP. Mol. Cell. Biochem. 1996, 165:151-153.
15. Sambrook J., Fritschi E.F., Maniatis T. Molecular Cloning: A Laboratory Manual 1989, Cold Spring Harbor Laboratory Press, New York.
16. Takahashi K., et al. Influence of missense mutation and silent mutation of LHb-subunit gene in Japanese patients with ovulatory disorders. Eur. J. Hum. Gen. 2003, 11:402-408.
17. Tapanainen J.S., et al. A new contributing factor to polycystic ovary syndrome: the genetic variant of luteinizing hormone. J. Clin. Endocrinol. Metab. 1999, 84:1711-1715.
18. The Rotterdam ESHRE/ASRM-sponsored PCOS Concensus Workshop Group Revised 2003 Concensus on diagnostic criteria and long term health risk related to polycystic ovary syndrome. Fertil. Steril. 2004, 81:19-25.
19. Valkenburg O., et al. Genetic polymorphisms of GnRH and gonadotrophic hormone receptors affect the phenotype of polycystic ovary syndrome. Hum. Reprod. 2009, 24:2014-2022.