Mu opioid receptor mRNA expression, binding, and functional coupling to G-proteins in human epileptic hippocampus

Hippocampus

Volumn 22, Issue 2, 2012, Pages 122-127

  Cuellar Herrera, Manola ^a   Velasco, Ana Luisa ^a   Velasco, Francisco ^a   Chavez, Laura ^b   Orozco Suarez, Sandra ^c   Armagan, Guliz ^d   Turunc, Ezgi ^d   Bojnik, Engin ^e   Yalcin, Ayfer ^d   Benyhe, Sandor ^e   Borsodi, Anna ^e   Alonso Vanegas, Mario ^f   Rocha, Luisa ^g  

^a HOSPITAL GENERAL DE MÉXICO   (Mexico)

^b HOSPITAL GENERAL DE MÉXICO   (Mexico)

^c National Medical Center   (Mexico)

^d EGE UNIVERSITY   (Turkey)

^e INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^f NATIONAL INSTITUTE OF NEUROLOGY AND NEUROSURGERY   (Mexico)

^g DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

Binding; G protein; Hippocampus; Mesial temporal lobe epilepsy; MRNA; Mu opiod receptor

Indexed keywords

ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); MESSENGER RNA; MU OPIATE RECEPTOR;

ADOLESCENT; ADULT; AGE; AGED; ARTICLE; AUTOPSY; BASAL GANGLION; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTROENCEPHALOGRAM; FEMALE; GENE EXPRESSION; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; MALE; NUCLEOTIDE SEQUENCE; PHARMACORESISTANT MESIAL TEMPORAL LOBE EPILEPSY; PRIORITY JOURNAL; PROTEIN ANALYSIS; RECEPTOR BINDING; RECEPTOR DENSITY; TEMPORAL LOBE EPILEPSY;

ADOLESCENT; ADULT; EPILEPSY, TEMPORAL LOBE; FEMALE; GTP-BINDING PROTEINS; HIPPOCAMPUS; HUMANS; MALE; MIDDLE AGED; RECEPTORS, OPIOID, MU; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; YOUNG ADULT;

EID: 84856103876     PISSN: 10509631     EISSN: 10981063     Source Type: Journal    
DOI: 10.1002/hipo.20891     Document Type: Article

References (36)

1. Albertson TE, Joy RM, Stark LG. 1984. Modification of kindled amygdaloid seizures by opiate agonists and antagonists. J Pharmacol Exp Ther 228: 620-627.
2. Bausch SB, Chavkin C. 1997. Changes in hippocampal circuitry after pilocarpine-induced seizures as revealed by opioid receptor distribution and activation. J Neurosci 17: 477-492.
3. Benyhe S, Farkas J, Tóth G, Wollemann M. 1997. Met5-enkephalin-Arg6-Phe7, an endogenous neuropeptide, binds to multiple opioid and nonopioid sites in rat brain. J Neurosci Res 48: 249-258.
4. Börner C, Kraus J, Schröder H, Ammer H, Höllt V. 2004. Transcriptional regulation of the human mu-opioid receptor gene by interleukin-6. Mol Pharmacol 66: 1719-1726.
5. Chakrabarti S, Regec A, Gintzler AR. 2005. Biochemical demonstration of mu-opioid receptor association with Gsalpha: Enhancement following morphine exposure. Mol Brain Res 135: 217-224.
6. Chan JS, Chiu TT, Wong YH. 1995. Activation of type II adenylyl cyclase by the cloned mu-opioid receptor: Coupling to multiple G proteins. J Neurochem 65: 2682-2689.
7. Costa T, Klinz FJ, Vachon L, Herz A. 1988. Opioid receptors are coupled tightly to G proteins but loosely to adenylate cyclase in NG108-15 cell membranes. Mol Pharmacol 34: 744-754.
8. Costa T, Lang J, Gless C, Herz A. 1990. Spontaneous association between opioid receptors and GTP-binding regulatory proteins in native membranes: Specific regulation by antagonists and sodium ions. Mol Pharmacol 37: 383-394.
9. Escribá PV, Ozaita A, García-Sevilla JA. 2004. Increased mRNA expression of alpha2A-adrenoceptors, serotonin receptors and mu-opioid receptors in the brains of suicide victims. Neuropsychopharmacology 29: 1512-1521.
10. Frost JJ, Mayberg HS, Fisher RS, Douglass KH, Dannals RF, Links JM, Wilson AA, Ravert HT, Rosenbaum AE, Snyder SH, Wagner HN. 1988. Mu-opiate receptors measured by positron emisson tomography are increased in temporal lobe epilepsy. Ann Neurol 23: 231-237.
11. Fujikawa DG. 2005. Prolonged seizures and cellular injury: Understanding the connection. Epilepsy Behav 7 ( Suppl 3): S3-S11.
12. Gabilondo AM, Meana JJ, García-Sevilla JA. 1995. Increased density of mu-opioid receptors in the postmortem brain of suicide victims. Brain Res 682: 245-250.
13. González-Maeso J, Torre I, Rodríguez-Puertas R, García-Sevilla JA, Guimón J, Meana JJ. 2002. Effects of age, postmortem delay and storage time on receptor-mediated activation of G-proteins in human brain. Neuropsychopharmacology 26: 468-478.
14. Hammers A, Asselin MC, Hinz R, Kitchen I, Brooks DJ, Duncan JS, Koepp MJ. 2007. Upregulation of opioid receptor binding following spontaneous epileptic seizures. Brain 130: 1009-1016.
15. Kenakin T. 1993. Efficacy. In: Kenakin T, editor. Pharmacologic Analysis of Drug-Receptor Interaction. New York: Raven Press. pp 249-277.
16. Liimatainen S, Fallah M, Kharazmi E, Peltola M, Peltola J. 2009. Interleukin-6 levels are increased in temporal lobe epilepsy but not in extra-temporal lobe epilepsy. J Neurol 256: 796-802.
17. Livak KJ, Schmittengen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR, the 2(-Delta Delta C(T) method. Methods 25: 402-408.
18. Lowry OH, Rosenbrough NJ, Farr RJ, Randall RJ. 1951. Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-273.
19. Madison DV, Nicoll RA. 1988. Enkephalin hyperpolarizes interneurones in the rat hippocampus. J Physiol 398: 123-130.
20. Murphy S, Pearce B. 1987. Functional receptors for neurotransmitters on astroglial cells. Neuroscience 22: 381-394.
21. Ono T, Kaneda T, Muto A, Yoshida T. 2009. Positive transcriptional regulation of the human mu opioid receptor gene by poly(ADP-ribose) polymerase-1 and increase of its DNA binding affinity based on polymorphism of G-172 T. J Biol Chem 284: 20175-20183.
22. 35S]guanylyl-5'-O-(gamma-thio)-triphosphate binding in human frontal cortex and cerebellum. Neurosci Lett 283: 213-216.
23. Rocha L, Engel JJr, Ackermann RF. 1991. Effects of chronic naloxone pretreatment on amygdaloid kindling in rats. Epilepsy Res 10: 103-110.
24. Rocha L, Ackermann RF, Nassir Y, Chugani HT, Engel JJr. 1993. Characterization of mu opioid receptor binding during amygdala kindling in rats and effects of chronic naloxone pretreatment: An autoradiographic study. Epilepsy Res 14: 195-208.
25. Rocha L, Evans CJ, Maidment NT. 1997. Amygdala kindling modifies extracellular opioid peptide content in hippocampus: A microdialysis study. J Neurochem 68: 616-624.
26. Rocha L, Orozco-Suarez S, Alonso-Vanegas M, Villeda-Hernandez J, Gaona A, Páldy E, Benyhe S, Borsodi A. 2009. Temporal lobe epilepsy causes selective changes in mu opioid and nociceptin receptor binding and functional coupling to G-proteins in human temporal neocortex. Neurobiol Dis 35: 466-473.
27. Rozen S, Skaletsky HJ. 2000. Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol 132: 365-386.
28. Scheer A, Cotecchia S. 1997. Constitutively active G protein-coupled receptors: Potential mechanisms of receptor activation. J Recept Signal Transduct Res 17: 57-73.
29. Siggins GR, Zieglgänsberger W. 1981. Morphine and opioid peptides reduce inhibitory synaptic potentials in hippocampal pyramidal cells in vitro without alteration of membrane potential. Proc Natl Acad Sci USA 78: 5235-5239.
30. Skyers PS, Einheber S, Pierce JP, Milner TA. 2003. Increased mu-opioid receptor labeling is found on inner molecular layer terminals of the dentate gyrus following seizures. Exp Neurol 179: 200-209.
31. Sloviter RS. 1994. The functional organization of the hippocampal dentate gyrus and its relevance to the pathogenesis of temporal lobe epilepsy. Ann Neurol 35: 640-654.
32. Soldatenkov VA, Chasovskikh S, Potaman VN, Trofimova I, Smulson ME, Dritschilo A. 2002. Transcriptional repression by binding of poly(ADP-ribose) polymerase to promoter sequences. J Biol Chem 277: 665-670.
33. Tortella FC, Robles L, Mosberg HI. 1987. Evidence for mu opioid receptor mediation of enkephalin-induced electroencephalographic seizures. J Pharmacol Exp Ther 240: 571-577.
34. Tripathi N, Khurshid P, Kumar S, Iyenga S. 2008. Expression of delta and mu opioid receptors in the ventricular and subventricular zones of the developing human neocortex. Neurosci Res 61: 257-270.
35. Velasco AL, Boleaga B, Brito F, Jimenez F, Gordillo JL, Velasco F, Velasco M. 2000. Absolute and relative predictor values of some non-invasive and invasive studies for the outcome of anterior temporal lobectomy. Arch Med Res 31: 62-74.
36. Yalcin A. 2004. The relative quantification of thioredoxin mRNA expression in the rat hippocampus by real-time PCR following oxidative stress. Acta Biochim Polym 51/54: 1059-1065.