Chronic N-acetylcysteine after cocaine self-administration produces enduring reductions in drug-seeking

Neuropsychopharmacology

Volumn 37, Issue 1, 2012, Pages 298-

  Reichel, Carmela M ^a   See, Ronald E ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; COCAINE; CYSTINE; DIAMORPHINE; GLUTAMIC ACID;

ADDICTION; CLINICAL EFFECTIVENESS; DRUG SEEKING BEHAVIOR; DRUG THERAPY; DRUG TOLERABILITY; HUMAN; NERVE CELL PLASTICITY; NEUROBIOLOGY; NOTE; NUCLEUS ACCUMBENS; PHARMACOLOGY; PRIORITY JOURNAL; PSYCHOPHYSIOLOGY; RELAPSE; TOBACCO DEPENDENCE; WITHDRAWAL SYNDROME;

ANIMALS; COCAINE; COCAINE-RELATED DISORDERS; CYSTINE; DOPAMINE UPTAKE INHIBITORS; DRUG INTERACTIONS; HUMANS; SELF ADMINISTRATION;

EID: 84856099702     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2011.164     Document Type: Note

References (6)

1. Amen SL, Piacentine LB, Ahmad ME, Li S-J, Mantsch JR, Risinger RC et al (2011). Repeated N-acetylcysteine reduces cocaine seeking in rodents and craving in cocaine-dependent humans. Neuropsychopharmacology 36: 871-878.
2. LaRowe SD, Myrick H, Hedden S, Mardikian P, Saladin M, McRae A et al (2007). Is cocaine desire reduced by N-acetylcysteine? Am J Psychiatry 164: 1115-1117. (Pubitemid 47121401)
3. Madayag A, Lobner D, Kau KS, Mantsch JR, Abdulhameed O, Hearing M et al (2007). Repeated N-acetylcysteine administration alters plasticitydependent effects of cocaine. J Neurosci 27: 13968-13976. (Pubitemid 351377873)
4. Mardikian PN, LaRowe SD, Hedden S, Kalivas PW, Malcolm RJ (2007). An open-label trial of N-acetylcysteine for the treatment of cocaine dependence: a pilot study. Prog Neuropsychopharmacol Biol Psychiatry 31: 389-394. (Pubitemid 46209420)
5. Moussawi K, Zhou W, Shen H, Reichel CM, See RE, Carr DB et al (2011). Reversing cocaine-induced synaptic potentiation provides enduring protection from relapse. Proc Natl Acad Sci USA 108: 385-390.
6. Reichel CM, Moussawi K, Do PH, Kalivas PW, See RE (2011). Chronic N-acetylcysteine during abstinence or extinction following cocaine selfadministration produces enduring reductions in drug-seeking. J Pharmacol Exp Ther 337: 487-493.