Determination of hydromorphone in human plasma by a sensitive RP-HPLC-ESI-MS method and its application to a clinical pharmacokinetic study in postoperative patients after low dose intravenous administration with infusion pump

Journal of Pharmaceutical and Biomedical Analysis

Volumn 61, Issue , 2012, Pages 15-21

  Sun, Luning ^a   Pan, Yinbin ^b   Ding, Li ^a   Luo, Xuemei ^a   Yan, Zhengyu ^a   Liu, Cunming ^b   Qian, Yanning ^b   Chu, Yan ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Hydromorphone; Pharmacokinetics; Postoperative patient; RP HPLC ESI MS

Indexed keywords

ACETIC ACID ETHYL ESTER; AMMONIUM ACETATE; BICARBONATE; BUFFER; FORMIC ACID; HYDROMORPHONE; METHANOL; NALOXONE;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CALIBRATION; CLINICAL ARTICLE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG ANALYSIS; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG SELECTIVITY; DRUG STABILITY; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; HUMAN; INFUSION PUMP; ION MONITORING; LOW DRUG DOSE; MALE; MAXIMUM PLASMA CONCENTRATION; MOLECULE; PHARMACOLOGICAL PARAMETERS; POSTOPERATIVE PAIN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTON TRANSPORT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ROOM TEMPERATURE; SURGICAL PATIENT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADOLESCENT; ADULT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, REVERSE-PHASE; FEMALE; HUMANS; HYDROMORPHONE; INFUSION PUMPS; INFUSIONS, INTRAVENOUS; MALE; MIDDLE AGED; POSTOPERATIVE CARE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; YOUNG ADULT;

EID: 84856095404     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2011.11.012     Document Type: Article

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