Distinctive morphological features of antibody-mediated and T-cell-mediated acute rejection in pancreas allograft biopsies

Current Opinion in Organ Transplantation

Volumn 17, Issue 1, 2012, Pages 93-99

  Papadimitriou, John C ^a   Drachenberg, Cinthia B ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Banff schema; C4d; donor specific antibody; graft loss; graft thrombosis; interacinar capillaritis

Indexed keywords

BORTEZOMIB; ECULIZUMAB; IMMUNOGLOBULIN; LYMPHOCYTE ANTIBODY; RITUXIMAB; STEROID;

ACINITIS; ACUTE GRAFT REJECTION; ALLOGRAFT; ANTIBODY MEDIATED REJECTION; ARTERITIS; ARTERY ENDOTHELIUM; BLOOD VESSEL INJURY; CAPILLARITIS; CLINICAL FEATURE; DIFFERENTIAL DIAGNOSIS; DUCTITIS; ENDARTERITIS; EOSINOPHIL; GRAFT FAILURE; GRAFT REJECTION; HUMAN; INFLAMMATION; INTERACINAR INFLAMMATION; INTIMAL ARTERITIS; MACROPHAGE; MONONUCLEAR CELL; NEUTROPHIL; PANCREAS BIOPSY; PANCREAS GRAFT REJECTION; PLASMA CELL; PLASMAPHERESIS; REVIEW; SCLEROSIS; T CELL MEDIATED REJECTION; T LYMPHOCYTE; VASCULITIS; VENULITIS;

ACUTE DISEASE; ANIMALS; BIOPSY; DIAGNOSIS, DIFFERENTIAL; GRAFT REJECTION; HUMANS; IMMUNITY, CELLULAR; IMMUNITY, HUMORAL; ISOANTIBODIES; PANCREAS TRANSPLANTATION; T-LYMPHOCYTES; TRANSPLANTATION, HOMOLOGOUS;

EID: 84856081913     PISSN: 10872418     EISSN: 15317013     Source Type: Journal    
DOI: 10.1097/MOT.0b013e32834ee754     Document Type: Review

References (35)

1. Colvin RB. Dimensions of antibody-mediated rejection. Am J Transplant 2010; 10:1509-1510.
2. Famulski KS, Einecke G, Sis B, et al. Defining the canonical form of T-cellmediated rejection in human kidney transplants. Am J Transplant 2010; 10:810-820.
3. Sis B, Mengel M, Haas M, et al. Banff '09 meeting report: antibody mediated graft deterioration and implementation of Banff working groups. Am J Transplant 2010; 10:464-471.
4. Solez K, Colvin RB, Racusen LC, et al. Banff 07 classification of renal allograft pathology: updates and future directions. Am J Transplant 2008; 8:753-760. (Pubitemid 351347767)
5. de Kort H, Munivenkatappa RB, Berger SP, et al. Pancreas allograft biopsies with positive C4d staining and anti-donor antibodies related to worse outcome for patients. Am J Transplant 2010; 10:1660-1667.
6. Drachenberg CB, Odorico J, Demetris AJ, et al. Banff schema for grading pancreas allograft rejection: working proposal by a multidisciplinary international consensus panel. Am J Transplant 2008; 8:1237-1249. (Pubitemid 351763668)
7. Munivenkatappa RB, Philosophe B, Papadimitriou JC, Drachenberg CB. Interacinar c4d staining in pancreas allografts. Transplantation 2009; 88:145-146.
8. Rangel EB, Malheiros DM, de Castro MC, et al. Antibody-mediated rejection(AMR) after pancreas and pancreas-kidney transplantation. Transpl Int 2010; 23:602-610.
9. Torrealba JR, Samaniego M, Pascual J, et al. C4d-positive interacinar capillaries correlates with donor-specific antibody-mediated rejection in pancreas allografts. Transplantation 2008; 86:1849-1856.
10. Troxell ML, Koslin DB, Norman D, et al. Pancreas allograft rejection: analysis of concurrent renal allograft biopsies and posttherapy follow-up biopsies. Transplantation 2010; 90:75-84.
11. Waki K, Terasaki PI, Kadowaki T. Long term pancreas allograft survival in simultaneous pancreas kidney transplantation by era: UNOS registry analysis. Diabetes Care 2010; 33:1789-1791.
12. Einecke G, Sis B, Reeve J, et al. Antibody-mediated microcirculation injury is the major cause of late kidney transplant failure. Am J Transplant 2009; 9:2520-2531.
13. Loupy A, Hill GS, Suberbielle C, et al. Significance of C4d Banff scores in early protocol biopsies of kidney transplant recipients with preformed donorspecific antibodies (DSA). Am J Transplant 2011; 11:56-65.
14. Gaber LW. Pancreas allograft biopsies in the management of pancreas transplant recipients: histopathologic review and clinical correlations. Arch Pathol Lab Med 2007; 131:1192-1199. (Pubitemid 47257631)
15. Fabio V, Daniele F, Monica DD, et al. Pancreas rejection after pandemic influenzavirus A(H(1) N(1)) vaccination or infection: a report of two cases. Transpl Int 2010; 24:e28-e29.
16. Katerinis I, Hadaya K, Duquesnoy R, et al. De Novo Anti-HLA Antibody After Pandemic H1N1 and Seasonal Influenza Immunization in Kidney Transplant Recipients. Am J Transplant 2011; 11:1727-1733.
17. Zanone MM, Favaro E, Quadri R, et al. Association of cytomegalovirus infections with recurrence of humoral and cellular autoimmunity to islet autoantigens and of type 1 diabetes in a pancreas transplanted patient. Transpl Int 2010; 23:333-337.
18. Drachenberg CB, Torrealba JR, Nankivell BJ, et al. Guidelines for the diagnosis of antibody-mediated rejection in pancreas allografts-updated Banff grading schema. A J Transplant 2011; 11:1792-1802.
19. Cashion AK, Sabek O, Driscoll C, et al. Serial analysis of biomarkers of acute pancreas allograft rejection. Clin Transplant 2010; 24:E214-E222.
20. Heidt S, San Segundo D, Shankar S, et al. Peripheral blood sampling for the detection of allograft rejection: biomarker identification and validation. Transplantation 2011; 92:1-9.
21. Papadimitriou JC, Drachenberg CB, Wiland A, et al. Histologic grading of acute allograft rejection in pancreas needle biopsy: correlation to serum enzymes, glycemia, and response to immunosuppressive treatment. Transplantation 1998; 66:1741-1745. (Pubitemid 29035002)
22. Howell WM, Harmer A, Briggs D, et al. British Society for Histocompatibility & Immunogenetics and British Transplantation Society guidelines for the detection and characterisation of clinically relevant antibodies in allotransplantation. Int J Immunogenet 2010; 37:435-437.
23. Drachenberg CB, Papadimitriou JC, Farney A, et al. Pancreas transplantation: the histologic morphology of graft loss and clinical correlations. Transplantation 2001; 71:1784-1791. (Pubitemid 32622491)
24. Papadimitriou JC, Drachenberg CB, Munivenkatappa R, et al. Glomerular inflammation in renal allografts biopsies after the first year: cell types and relationship with antibody-mediated rejection and graft outcome. Transplantation 2010; 90:1478-1485.
25. Pascual J, Pirsch JD, Odorico JS, et al. Alemtuzumab induction and antibodymediated kidney rejection after simultaneous pancreas-kidney transplantation. Transplantation 2009; 87:125-132.
26. Pascual J, Samaniego MD, Torrealba JR, et al. Antibody-mediated rejection of the kidney after simultaneous pancreas-kidney transplantation. J Am Soc Nephrol JASN 2008; 19:812-824.
27. Burke GW 3rd, Vendrame F, Pileggi A, et al. Recurrence of autoimmunity following pancreas transplantation. Curr Diabetes Rep 2011; 11:413-419.
28. Muthusamy AS, Giangrande PL, Friend PJ. Pancreas allograft thrombosis. Transplantation 2010; 90:705-707.
29. Weir MR, Bartlett ST, Drachenberg CB. Eosinophilia as an early indicator of pancreatic allograft rejection. Clinical Transplantation 2011. [Epub ahead of print] Case report demonstrating the value of eosinophils in the diagnosis of T-cellmediated pancreas rejection and graphic demonstration of histological and clinical treatment response.
30. Drachenberg CB, Papadimitriou JC. The inflamed pancreas transplant: histological differential diagnosis. Seminars Diagnos Pathol 2004; 21: 255-259. (Pubitemid 41390070)
31. Thaunat O. Pathophysiologic significance of B-cell clusters in chronically rejected grafts. Transplantation 2011; 92:121-126.
32. Papadimitriou JC, Drachenberg CB, Klassen DK, et al. Histological grading of chronic pancreas allograft rejection/graft sclerosis. Am J Transplant 2003; 3:599-605. (Pubitemid 36612843)
33. Klassen DK, Drachenberg CB, Papadimitriou JC, et al. CMV allograft pancreatitis: diagnosis, treatment, and histological features. Transplantation 2000; 69:1968-1971. (Pubitemid 30340367)
34. Drachenberg CB, Abruzzo LV, Klassen DK, et al. Epstein-Barr virus-related posttransplantation lymphoproliferative disorder involving pancreas allografts: histological differential diagnosis from acute allograft rejection. Hum Pathol 1998; 29:569-577. (Pubitemid 28272710)
35. Rogers J, Farney AC, Al-Geizawi S, et al. Pancreas transplantation: lessons learned from a decade of experience at Wake Forest Baptist Medical Center. Rev Diabetic Stud RDS 2011; 8:17-27.