Association study of functional polymorphisms in serotonin transporter gene with temporal lobe epilepsy in Han Chinese population

European Journal of Neurology

Volumn 19, Issue 2, 2012, Pages 351-353

  Li, J ^a   Lin, H ^b   Zhu, X ^a   Li, L ^b   Wang, X ^a   Sun, W ^b   Wu, X ^a   Liu, A ^b   Niu, F ^a   Wang, Y ^b   Liu, Y ^a  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Functional polymorphisms; Serotonin transporter; Temporal lobe epilepsy

Indexed keywords

SEROTONIN TRANSPORTER;

ADULT; ALLELE; ARTICLE; CHINESE; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; TEMPORAL LOBE EPILEPSY;

ADULT; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; CHINA; EPILEPSY, TEMPORAL LOBE; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 84856066273     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/j.1468-1331.2011.03521.x     Document Type: Article

References (9)

1. Didelot A, Ryvlin P, Lothe A, Merlet I, Hammers A, Mauguiere F. PET imaging of brain 5-HT1A receptors in the preoperative evaluation of temporal lobe epilepsy. Brain 2008; 131: 2751-2764.
2. Rocha L, Lorigados-Pedre L, Orozco-Suarez S, et al. Autoradiography reveals selective changes in serotonin binding in neocortex of patients with temporal lobe epilepsy. Prog Neuropsychopharmacol Biol Psychiatry 2007; 31: 1208-1218.
3. Rammoorthy S, Bauman AL, Moore KR, et al. Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. Proc Natl Acad Sci USA 1993; 90: 2542-2546.
4. Wendland JR, Martin BJ, Kruse MR, Lesch KP, Murphy DL. Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531. Mol Psychiatry 2006; 11: 224-226.
5. Delbruck SJ, Wendel B, Grunewald I, et al. A novel allelic variant of the human serotonin transporter gene regulatory polymorphism. Cytogenet Cell Genet 1997; 79: 214-220.
6. Manna I, Labate A, Gambardella A, et al. Serotonin transporter gene (5-Htt): association analysis with temporal lobe epilepsy. Neurosci Lett 2007; 421: 52-56.
7. Stefulj J, Bordukalo-Niksic T, Hecimovic H, Demarin V, Jernej B. Epilepsy and serotonin (5HT): variations of 5HT-related genes in temporal lobe epilepsy. Neurosci Lett 2010; 478: 29-31.
8. Theodore WH, Hasler G, Giovacchini G, et al. Reduced hippocampal 5HT1A PET receptor binding and depression in temporal lobe epilepsy. Epilepsia 2007; 48: 1526-1530.
9. Fabre V, Beaufour C, Evrard A, et al. Altered expression and functions of serotonin 5-HT1A and 5-HT1B receptors in knock-out mice lacking the 5-HT transporter. Eur J Neurosci 2000; 12: 2299-2310.