Large eddy simulation of LDL surface concentration in a subject specific human aorta

Journal of Biomechanics

Volumn 45, Issue 3, 2012, Pages 537-542

  Lantz, Jonas ^a   Karlsson, Matts ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

Author keywords

Atherosclerosis; Disturbed flow; Low density lipoprotein; Wall shear stress

Indexed keywords

ARTERIAL WALL; ATHEROSCLEROSIS; BLOOD FLOW; CARDIAC CYCLES; DISTURBED FLOW; FLUID TRANSPORT; LOW DENSITY LIPOPROTEINS; NEAR-WALL; NEAR-WALL FLOWS; PULSATILE BLOOD FLOW; SUBJECT-SPECIFIC; SURFACE CONCENTRATION; TEMPORAL CHANGE; VELOCITY PROFILES; WALL SHEAR STRESS;

BLOOD; CONCENTRATION (PROCESS); DISEASES; HEMODYNAMICS; LARGE EDDY SIMULATION; LIPIDS; SHEAR STRESS; WALL FLOW;

BLOOD VESSELS;

LOW DENSITY LIPOPROTEIN;

AORTA FLOW; ARTICLE; BIOACCUMULATION; BLOOD FLOW; BLOOD FLOW VELOCITY; CONTROLLED STUDY; DIASTOLE; FLOW RATE; FLUID TRANSPORT; HEART CYCLE; HEART HEMODYNAMICS; HUMAN; LIPOPROTEIN BLOOD LEVEL; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PROCESS MODEL; SENSITIVITY ANALYSIS; SHEAR STRESS; SURFACE PROPERTY; SYSTOLE; VALIDATION PROCESS;

AORTA; ATHEROSCLEROSIS; BLOOD FLOW VELOCITY; COMPUTER SIMULATION; HUMANS; LIPOPROTEINS, LDL; MODELS, CARDIOVASCULAR; STRESS, MECHANICAL;

EID: 84856062132     PISSN: 00219290     EISSN: 18732380     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2011.11.039     Document Type: Article

References (33)

1. Berceli S.A., Warty V.S., Sheppeck R.A., Mandarino W.A., Tanksale S.K., Borovetz H.S. Hemodynamics and low density lipoprotein metabolism. Rates of low density lipoprotein incorporation and degradation along medial and lateral walls of the rabbit aorto-iliac bifurcation. Arteriosclerosis 1990, 10:686-694.
2. Ethier C.R. Computational modeling of mass transfer and links to atherosclerosis. Annals of Biomedical Engineering 2002, 30:461-471.
3. Fazli S., Shirani E., Sadeghi M.R. Numerical simulation of LDL mass transfer in a common carotid artery under pulsatile flows. Journal of Biomechanics 2011, 44:68-76.
4. Guretzki H.J., Gerbitz K.D., Olgemoller B., Schleicher E. Atherogenic levels of low density lipoprotein alter the permeability and composition of the endothelial barrier. Atherosclerosis 1994, 107:15-24.
5. Heiberg E., Sjogren J., Ugander M., Carlsson M., Engblom H., Arheden H. Design and validation of Segment-freely available software for cardiovascular image analysis. BMC Medical Imaging 2010, 10:1.
6. Hoff H.F., Wagner W.D. Plasma low density lipoprotein accumulation in aortas of hypercholesterolemic swine correlates with modifications in aortic glycosaminoglycan composition. Atherosclerosis 1986, 61:231-236.
7. Karino T., Goldsmith H.L., Motomiya M., Mabuchi S., Sohara Y. Flow patterns in vessels of simple and complex geometries. Annals of the New York Academy of Sciences 1987, 516:422-441.
8. Kolandavel M.K., Fruend E.T., Ringgaard S., Walker P.G. The effects of time varying curvature on species transport in coronary arteries. Annals of Biomedical Engineering 2006, 34:1820-1832.
9. Liu X., Fan Y., Deng X. Effect of the endothelial glycocalyx layer on arterial LDL transport under normal and high pressure. Journal of Theoretical Biology 2011, 283:71-81.
10. Liu X., Fan Y., Deng X., Zhan F. Effect of non-Newtonian and pulsatile blood flow on mass transport in the human aorta. Journal of Biomechanics 2011, 44:1123-1131.
11. Liu X., Pu F., Fan Y., Deng X., Li D., Li S. A numerical study on the flow of blood and the transport of LDL in the human aorta: the physiological significance of the helical flow in the aortic arch. American Journal of Physiology-Heart and Circulatory Physiology 2009, 297:163-170.
12. Mittal R., Simmons S.P., Najjar F. Numerical study of pulsatile flow in a constricted channel. Journal of Fluid Mechanics 2003, 485:337-378.
13. Morbiducci U., Ponzini R., Rizzo G., Cadioli M., Esposito A., De Cobelli F., Del Maschio A., Montevecchi F.M., Redaelli A. In vivo quantification of helical blood flow in human aorta by time-resolved three-dimensional cine phase contrast magnetic resonance imaging. Annals of Biomedical Engineering 2009, 37:516-531.
14. Nicoud F., Ducros F. Subgrid-scale stress modelling based on the square of the velocity gradient tensor. Flow, Turbulence and Combustion 1999, 62:183-200.
15. Nielsen L.B. Transfer of low density lipoprotein into the arterial wall and risk of atherosclerosis. Atherosclerosis 1996, 123:1-15.
16. Olgac U., Poulikakos D., Saur S.C., Alkadhi H., Kurtcuoglu V. Patient-specific three-dimensional simulation of LDL accumulation in a human left coronary artery in its healthy and atherosclerotic states. American Journal of Physiology-Heart and Circulatory Physiology 2009, 296:1969-1982.
17. Paul M.C., Mamun Molla M., Roditi G. Large-Eddy simulation of pulsatile blood flow. Medical Engineering & Physics 2009, 31:153-159.
18. Peacock J., Jones T., Tock C., Lutz R. The onset of turbulence in physiological pulsatile flow in a straight tube. Experiments in Fluids 1998, 24:1-9.
19. Phelps J.E., DePaola N. Spatial variations in endothelial barrier function in disturbed flows in vitro. American Journal of Physiology-Heart and Circulatory Physiology 2000, 278:H469-476.
20. Ross R., Harker L. Hyperlipidemia and atherosclerosis. Science 1976, 193:1094-1100.
21. Soulis J.V., Fytanidis D.K., Papaioannou V.C., Giannoglou G.D. Wall shear stress on LDL accumulation in human RCAs. Medical Engineering & Physics 2010, 32:867-877.
22. Stalder A.F., Frydrychowicz A., Russe M.F., Korvink J.G., Hennig J., Li K., Markl M. Assessment of flow instabilities in the healthy aorta using flow-sensitive MRI. Journal of Magnetic Resonance Imaging 2011, 33:839-846.
23. Stangeby D.K., Ethier C.R. Computational analysis of coupled blood-wall arterial LDL transport. Journal of Biomechanical Engineering 2002, 124:1-8.
24. Stein P.D., Sabbah H.N. Turbulent blood flow in the ascending aorta of humans with normal and diseased aortic valves. Circulation Research 1976, 39:58-65.
25. Sun N., Wood N.B., Hughes A.D., Thom S.A., Xu X.Y. Fluid-wall modelling of mass transfer in an axisymmetric stenosis: effects of shear-dependent transport properties. Annals of Biomedical Engineering 2006, 34:1119-1128.
26. Tan F.P., Wood N.B., Tabor G., Xu X.Y. Comparison of LES of steady transitional flow in an idealized stenosed axisymmetric artery model with a RANS transitional model. Journal of Biomechanical Engineering 2011, 133:051001.
27. Tarbell J.M. Mass transport in arteries and the localization of atherosclerosis. Annual Review of Biomedical Engineering 2003, 5:79-118.
28. Vincent P.E., Sherwin S.J., Weinberg P.D. The effect of a spatially heterogeneous transmural water flux on concentration polarization of low density lipoprotein in arteries. Biophysical Journal 2009, 96:3102-3115.
29. Vincent P.E., Sherwin S.J., Weinberg P.D. The effect of the endothelial glycocalyx layer on concentration polarisation of low density lipoprotein in arteries. Journal of Theoretical Biology 2010, 265:1-17.
30. Wada S., Karino T. Theoretical study on flow-dependent concentration polarization of low density lipoproteins at the luminal surface of a straight artery. Biorheology 1999, 36:207-223.
31. Wada S., Karino T. Prediction of LDL concentration at the luminal surface of a vascular endothelium. Biorheology 2002, 39:331-336.
32. Wada S., Karino T. Theoretical prediction of low-density lipoproteins concentration at the luminal surface of an artery with a multiple bend. Annals of Biomedical Engineering 2002, 30:778-791.
33. Yoganathan A.P., Chandran K.B., Sotiropoulos F. Flow in prosthetic heart valves: state-of-the-art and future directions. Annals of Biomedical Engineering 2005, 33:1689-1694.