The relationship between retinol-binding protein 4 levels, insulin resistance, androgen hormones and polycystic ovary syndrome

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 72, Issue 1, 2012, Pages 39-44

  Mellati, Ali Awsat ^a   Sharifi, Faranak ^a   Sajadinejad, Mohsen ^b   Sohrabi, Davood ^b   Mazloomzadeh, Saeideh ^a  

^a ZANJAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b ZANJAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Androgen hormones; Homeostatic model assessment of insulin resistance; Insulin resistance; Polycystic ovary syndrome; Retinol binding protein 4

Indexed keywords

ANDROGEN; GLUCOSE; INSULIN; LIPID; PRASTERONE SULFATE; RETINOL BINDING PROTEIN 4; TESTOSTERONE;

ADOLESCENT; ADULT; ARTICLE; BODY MASS; CASE CONTROL STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; TESTOSTERONE BLOOD LEVEL; WAIST CIRCUMFERENCE;

ADOLESCENT; ADULT; CASE-CONTROL STUDIES; DEHYDROEPIANDROSTERONE SULFATE; FEMALE; HUMANS; INSULIN; INSULIN RESISTANCE; LIPIDS; LOGISTIC MODELS; MIDDLE AGED; POLYCYSTIC OVARY SYNDROME; RETINOL-BINDING PROTEINS, PLASMA; TESTOSTERONE; YOUNG ADULT;

EID: 84856038806     PISSN: 00365513     EISSN: 15027686     Source Type: Journal    
DOI: 10.3109/00365513.2011.626071     Document Type: Article

References (28)

1. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnosis criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 2004;81:19-25.
2. Franks S. Polycystic ovary syndrome. N Engl J Med 1995;333:853-61.
3. Murray R. Polycystic ovary syndrome, obesity and insulin resistance: the new female triad. Adv Nurse Pract 2004; 12:22-35.
4. Essah PA, Nestler JE. The metabolic syndrome in polycystic ovary syndrome. J Endocrinol Invest 2006:29;270-80.
5. Staiger H, Haring HU. Adipocytokines: fat-derived humoral mediators of metabolic homeostasis. Exp Clin Endocrinol Diabetes 2005;113:67-79. (Pubitemid 40388776)
6. Yang Q, Graham TE, Mody N, Pritner F, Peroni OD, Zabolotny JM, Kotani K, Quadro I, Kahn BB. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 2005;436:356-62. (Pubitemid 41065039)
7. Blaner WS. Retinol-binding protein: the serum transport protein for vitamin A. Endocr Rev 1989;10:308-16. (Pubitemid 19223063)
8. Newcomer ME, Ong DE. Plasma retinol binding protein: structure and function of the prototypic lipocalin. Biochim Biophys Acta 2000;1482:57-64.
9. Muoio DM, Newgard CB. Metabolism: a is for adipokine. Nature 2005;436:337-8. (Pubitemid 41059036)
10. Graham TE, Yang Q, Bluher M, Hammarsted A, Claraldi TP, Henry RR, Wason CJ, Oberbach A, Jansson PA, Smith U, Kahn BB. Retinol binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N Engl J Med 2006;354:2552-63. (Pubitemid 43882351)
11. Haider DG, Schindler K, Prager G, Bohdjahan A, Luger A, Wolzt M, Ludvik B. Serum retinol binding protein 4 is reduced after weight loss in morbidly obese subjects. J Clin Endocrinol Metab 2007; 92:1168-71. (Pubitemid 46465698)
12. Balagopal P, Graham TE, Kahn BB, Altomare A, Funanage V, George D. Reduction of elevated serum retinol binding protein in obese children by life style intervention: association with subclinical infl ammation. J Clin Endocrinol Metab 2007;92:1971-4. (Pubitemid 46997219)
13. Weiping L, Qingfeng C, Shikun M, Xiurong L, Hua Q, Xiaoshu B, Suhua Z, Qifu L. Elevated serum RBP4 is associated with insulin resistance in women with polycystic ovary syndrome. Endocrine 2006;30:283-7. (Pubitemid 47010964)
14. Lee JW, Im JA, Lee DC, Lee HR, Shim JY. Retinol-binding protein in nonobese women with polycystic ovary syndrome. Clin Endocrinol (OXF) 2008;68:786-90.
15. Tan BK, Chen J, Lehnert H, Kennedy R, Randeva HS. Raised serum, adipocyte, and adipose tissue retinol binding protein 4 in overweight women with polycystic ovary syndrome: effects of gonadal and adrenal steroids. J Clin Endo-crinol Metab 2007;92:2764-72. (Pubitemid 47037388)
16. Chan TF, Tsai YC, Chiu PR, Chen YL, Lee CH, Tsai M. Serum retinol-binding protein 4 levels in nonobese women with polycystic ovary syndrome. Fertil Steril 2010;93: 869-73.
17. Hutchison SK, Harrison C, Stepto V, Meyer C, Teede HJ. Retinol-binding protein 4 and insulin resistance in polycys-tic ovary syndrome. Diabetes Care 2008;31:1427-32.
18. Yildiz BO, Bozdag G, Otegen U, Harmanci A, Boynukalin K, Vural Z, Kirazli S, Yarali H. Visfatin and retinol-binding protein 4 concentration in lean, glucose-tolerant women with PCOS. Reprod Biomed Online 2010;20:150-5.
19. Hahn S, Backhaus M, Broecker-Preuss M, Tan S, Dietz T, Kimmig R, Schmidt M, Mann K, Janssen OE. Retinol binding protein 4 levels are elevated in polycystic ovary syndrome women with obesity and impaired glucose metabolism. Eur J Endocrinol 2007;157:201-7. (Pubitemid 47233125)
20. Aigner E, Bachofner N, Klein K, De Geyter C, Hohla F, Patsch W, Datz C. Retinol-binding protein 4 in polycystic ovary syndrome-association with steroid hormones and response to pioglitazone treatment. J Clin Endocrinol Metab 2009;94:1229-35.
21. Möhlig M, Weickert MO, Ghadamgahi E, Arafat A, Spranger J, Pfeiffer AFH, Schofl C. Retinol-binding protein 4 is associated with insulin resistance, but appears unsuited for metabolic screening in women with polycystic ovary syndrome. Eur J Endocrinol 2008;158:517-23. (Pubitemid 351606347)
22. Jellife DB. The assessment of the nutritional status of the community. Geneva: WHO, 1966.
23. Diamanti-Kandarakis E, Livadas S, Kandarakis SA, Popassotiriou I, Margdi A. Low free plasma levels of retinol-binding protein 4 in insulin-resistant subjects with polycystic ovary syndrome. J Endocrinol Invest 2008;31: 950-5.
24. Barber TM, Hazell M, Christodoulides C, Golding SJ, Alvey C, Burling K, Vidal-Puig A, Groome NP, Wass JA, Franks S, McCarthy MI. Serum levels of retinol-binding protein 4 and adiponectin in women with polycystic ovary syndrome: associations with visceral fat but no evidence for fat mass-independent effects on pathogenesis in this condition. J Clin Endocrinol Metab 2008;93:2859-65. (Pubitemid 352008562)
25. Kloting N, Graham TE, Berndt J, Kralisch S, Kovacs P, Wason CJ, Faschauer M, Stumvoll M, Bluher M, Kahn BB. Serum retinol-binding protein in more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass. Cell Metab 2007;6:79-87. (Pubitemid 46995778)
26. Palmer MR, Gordon CM, Kartashov AL, Legro RS, Emans SJ, Dunailf A. Screening for abnormal glucose tolerance in adolescents with polycystic ovary syndrome. J Clin Endo-crinol Metab 2002;87:1017-23. (Pubitemid 36121058)
27. Arslanian SA, Lewy VD, Danadian K. Glucose intolerance in obese adolescents with polycystic ovary syndrome: roles of insulin resistance and β-cell dysfunction and risk of cardiovascular disease. J Clin Endocrinol Metab 2001;86: 66-71. (Pubitemid 32109777)
28. Yao-Borengasser A, Varma V, Bodles AM, Rasouli N, Phanavanh B, Lee MJ, Starks T, Kern LM, Spencer HJ 3rd, Rashidi AA, McGehee RE Jr, Fried SK, Kern PA. Retinol binding protein 4 expression in humans: relationship to insulin resistance, infl ammation and response to pioglita-zone. J Clin Endocrinol Metab 2007;92:2590-7. (Pubitemid 47037362)