Gestational methylazoxymethanol acetate Administration alters proteomic and metabolomic markers of hippocampal glutamatergic transmission

Neuropsychopharmacology

Volumn 37, Issue 2, 2012, Pages 319-320

  Lodge, Daniel J ^a   Grace, Anthony A ^b  

^a University of Texas Health Science Center   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; GLUTAMIC ACID; METHYLAZOXYMETHANOL ACETATE;

AMINO ACID TRANSPORT; COMPUTER MODEL; HIPPOCAMPUS; IMMUNOBLOTTING; METABOLOMICS; NERVE CELL PLASTICITY; NONHUMAN; NOTE; PREGNANCY; PREPULSE INHIBITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SUBUNIT; PROTEOMICS; SIGNAL TRANSDUCTION; SOCIAL INTERACTION; STARTLE REFLEX; SYNAPTIC TRANSMISSION; WORKING MEMORY;

ANIMALS; FEMALE; HIPPOCAMPUS; HUMANS; MALE; METHYLAZOXYMETHANOL ACETATE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; SCHIZOPHRENIA; SYNAPTIC TRANSMISSION;

EID: 84856028542     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2011.255     Document Type: Note

References (8)

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2. Hradetzky E, Sanderson TM, Tsang TM, Sherwood JL, Fitzjohn SM, Lakics V et al (2011). The methylazoxymethanol acetate (MAM-E17) rat model: molecular and functional effects in the hippocampus. Neuropsychopharmacology 37: 364-377.
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5. Lodge DJ, Behrens MM, Grace AA (2009a). A loss of parvalbumincontaining interneurons is associated with diminished oscillatory activity in an animal model of schizophrenia. J Neurosci 29: 2344-2354.
6. Lodge DJ, Grace AA (2009b). Gestational methylazoxymethanol acetate administration: a developmental disruption model of schizophrenia. Behav Brain Res 204: 306-312.
7. Tsai G, Coyle JT (2002). Glutamatergic mechanisms in schizophrenia. In Annual Review of Pharmacology and Toxicology. pp 165-179. (Pubitemid 34160524)
8. Valenti O, Cifelli P, Gill KM, Grace AA (2011). Antipsychotic Drugs Rapidly Induce Dopamine Neuron Depolarization Block in a Developmental Rat Model of Schizophrenia. J Neurosci 31: 12330-12338.