The stress hormone copeptin: A new prognostic biomarker in acute illness

Swiss Medical Weekly

Volumn 140, Issue SEPTEMBER, 2010, Pages

  Katan, Mira ^a   Christ Crain, Mirjam ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Acute illness; Biomarker; Copeptin; Outcome; Pneumonia; Prognosis; Sepsis; Stroke

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; COPEPTIN; CORTICOTROPIN RELEASING FACTOR; HYDROCORTISONE; STRESS HORMONE; TROPONIN T; UNCLASSIFIED DRUG; VASOPRESSIN;

ACCURACY; ACUTE DISEASE; ACUTE HEART INFARCTION; APACHE; BLOOD CELL COUNT; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL DECISION MAKING; COMMUNITY ACQUIRED PNEUMONIA; DIAGNOSTIC ACCURACY; DISEASE SEVERITY; HEART DISEASE; HEART FAILURE; HEMODYNAMICS; HOMEOSTASIS; HORMONE BLOOD LEVEL; HORMONE SYNTHESIS; HUMAN; HYPOPHYSIS ADRENAL SYSTEM; ISCHEMIC HEART DISEASE; LOWER RESPIRATORY TRACT INFECTION; LUNG PARENCHYMA; MORTALITY; NATIONAL INSTITUTES OF HEALTH STROKE SCALE; NERVE CELL NECROSIS; NONHUMAN; OUTCOME ASSESSMENT; PNEUMONIA; PREDICTIVE VALUE; PROGNOSIS; RANKIN SCALE; REVIEW; SENSITIVITY AND SPECIFICITY; SEPSIS; SEPTIC SHOCK; STRESS; STROKE; SURVIVAL;

EID: 84856024137     PISSN: 14247860     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (45)

1. McEwen BS. Physiology and neurobiology of stress and adaptation: central role of the brain. Physiol Rev. 2007;87(3):873-904. (Pubitemid 47086281)
2. Charmandari E, Tsigos C, Chrousos G. Endocrinology of the stress response. Annu Rev Physiol. 2005;67:259-84. (Pubitemid 40409509)
3. Chrousos GP, Gold PW. The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. JAMA. 1992;267(9):1244-52.
4. Volpi S, Rabadan-Diehl C, Aguilera G. Vasopressinergic regulation of the hypothalamic pituitary adrenal axis and stress adaptation. Stress. 2004;7(2):75-83. (Pubitemid 39013697)
5. Aguilera G, Subburaju S, Young S, Chen J. The parvocellular vasopressinergic system and responsiveness of the hypothalamic pituitary adrenal axis during chronic stress. Prog Brain Res. 2008;170:29-39. (Pubitemid 352010218)
6. Tanoue A, Ito S, Honda K, Oshikawa S, Kitagawa Y, Koshimizu TA, et al. The vasopressin V1b receptor critically regulates hypothalamic-pituitary-adrenal axis activity under both stress and resting conditions. J Clin Invest. 2004;113(2):302-9. (Pubitemid 38544214)
7. Joels M, Baram TZ. The neuro-symphony of stress. Nat Rev Neurosci. 2009;10(6):459-66.
8. Petraglia F, Genazzani AD, Aguzzoli L, Gallinelli A, de Vita D, Caruso A, et al. Pulsatile fluctuations of plasma-gonadotropin-releasing hormone and corticotropin-releasing factor levels in healthy pregnant women. Acta Obstet Gynecol Scand. 1994;73(4):284-9. (Pubitemid 24121485)
9. Evans MJ, Livesey JH, Ellis MJ, Yandle TG. Effect of anticoagulants and storage temperatures on stability of plasma and serum hormones. Clin Biochem. 2001;34 (2):107-12. (Pubitemid 32322701)
10. Latendresse G, Ruiz RJ. Bioassay research methodology: measuring CRH in pregnancy. Biol Res Nurs. 2008;10 (1):54-62.
11. Struck J, Morgenthaler NG, Bergmann A. Copeptin, a stable peptide derived from the vasopressin precursor, is elevated in serum of sepsis patients. Peptides. 2005;26(12):2500-4. (Pubitemid 41676723)
12. Struck J, Morgenthaler NG, Bergmann A. Copeptin, a stable peptide derived from the vasopressin precursor, is elevated in serum of sepsis patients. Peptides. 2005;26(12):2500-4. (Pubitemid 41676723)
13. Donald RA, Perry EG, Wittert GA, Chapman M, Livesey JH, Ellis MJ, et al. The plasma ACTH, AVP, CRH and catecholamine responses to conventional and laparoscopic cholecystectomy. Clin Endocrinol. (Oxf) 1993;38(6):609-15. (Pubitemid 23168475)
14. Udelsman R, Norton JA, Jelenich SE, Goldstein DS, Linehan WM, Loriaux DL, et al. Responses of the hypothalamic-pituitary-adrenal and renin-angiotensin axes and the sympathetic system during controlled surgical and anesthetic stress. J Clin Endocrinol Metab. 1987;64(5):986-94. (Pubitemid 17067433)
15. Widmer IE, Puder JJ, Konig C, Pargger H, Zerkowski HR, Girard J, et al. Cortisol response in relation to the severity of stress and illness. J Clin Endocrinol Metab. 2005;90(8):4579-86. (Pubitemid 41159346)
16. Katan M, Morgenthaler N, Widmer I, Puder JJ, Konig C, Muller B, et al. Copeptin, a stable peptide derived from the vasopressin precursor, correlates with the individual stress level. Neuro Endocrinol Lett. 2008;29(3):341-6.
17. Sapolsky RM, Pulsinelli WA. Glucocorticoids potentiate ischemic injury to neurons: therapeutic implications. Science. 1985;229(4720):1397-400. (Pubitemid 16222382)
18. Morse JK, Davis JN. Regulation of ischemic hippocampal damage in the gerbil: adrenalectomy alters the rate of CA1 cell disappearance. Exp Neurol. 1990;110(1):86-92. (Pubitemid 20376004)
19. Smith-Swintosky VL, Pettigrew LC, Sapolsky RM, Phares C, Craddock SD, Brooke SM, et al. Metyrapone, an inhibitor of glucocorticoid production, reduces brain injury induced by focal and global ischemia and seizures. J Cereb Blood Flow Metab. 1996;16(4):585-98. (Pubitemid 26227067)
20. Morgenthaler NG, Muller B, Struck J, Bergmann A, Redl H, Christ-Crain M. Copeptin, a Stable Peptide of the Arginine Vasopressin Precursor, Is Elevated in Hemorrhagic and Septic Shock. Shock 2007.
21. Lindner KH, Strohmenger HU, Ensinger H, Hetzel WD, Ahnefeld FW, Georgieff M. Stress hormone response during and after cardiopulmonary resuscitation. Anesthesiology. 1992;77(4):662-8.
22. Muller B, Morgenthaler N, Stolz D, Schuetz P, Muller C, Bingisser R, et al. Circulating levels of copeptin, a novel biomarker, in lower respiratory tract infections. Eur J Clin Invest. 2007;37(2):145-52. (Pubitemid 46066494)
23. Stolz D, Christ-Crain M, Morgenthaler NG, Leuppi J, Miedinger D, Bingisser R, et al. Copeptin, C-reactive protein, and procalcitonin as prognostic biomarkers in acute exacerbation of COPD. Chest. 2007;131(4):1058-67. (Pubitemid 46608707)
24. Schrier RW, Abraham WT. Hormones and hemodynamics in heart failure. N Engl J Med. 1999;341(8):577-85. (Pubitemid 29384167)
25. Stoiser B, Mortl D, Hulsmann M, Berger R, Struck J, Morgenthaler NG, et al. Copeptin, a fragment of the vasopressin precursor, as a novel predictor of outcome in heart failure. Eur J Clin Invest. 2006;36(11):771-8. (Pubitemid 44569965)
26. Gegenhuber A, Struck J, Dieplinger B, Poelz W, Pacher R, Morgenthaler NG, et al. Comparative evaluation of B-type natriuretic peptide, mid-regional pro-A-type natriuretic peptide, mid-regional pro-adrenomedullin, and Copeptin to predict 1-year mortality in patients with acute destabilized heart failure. J Card Fail. 2007;13(1):42-9. (Pubitemid 46343794)
27. Khan SQ, Dhillon OS, O'Brien RJ, Struck J, Quinn PA, Morgenthaler NG, et al. C-terminal provasopressin (copeptin) as a novel and prognostic marker in acute myocardial infarction: Leicester Acute Myocardial Infarction Peptide (LAMP) study. Circulation. 2007;115(16):2103-10. (Pubitemid 46659061)
28. Tang WH, Francis GS, Morrow DA, Newby LK, Cannon CP, Jesse RL, et al. National Academy of Clinical Biochemistry Laboratory Medicine practice guidelines: Clinical utilization of cardiac biomarker testing in heart failure. Circulation. 2007;116 (5):e99-109.
29. Lloyd-Jones D, Adams R, Carnethon M, De Simone G, Ferguson TB, Flegal K, et al. Heart disease and stroke statistics - 2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2009;119 (3):e21-181.
30. Cooper R, Cutler J, Desvigne-Nickens P, Fortmann SP, Friedman L, Havlik R, et al. Trends and disparities in coronary heart disease, stroke, and other cardiovascular diseases in the United States: findings of the national conference on cardiovascular disease prevention. Circulation. 2000;102(25):3137-47.
31. Counsell C, Dennis M, McDowall M. Predicting functional outcome in acute stroke: comparison of a simple six variable model with other predictive systems and informal clinical prediction. J Neurol Neurosurg Psychiatry. 2004;75(3):401-5. (Pubitemid 38338769)
32. Whiteley W, Chong WL, Sengupta A, Sandercock P. Blood markers for the prognosis of ischemic stroke: a systematic review. Stroke. 2009;40(5):e380-9.
33. Fassbender K, Schmidt R, Mossner R, Daffertshofer M, Hennerici M. Pattern of activation of the hypothalamic-pituitary-adrenal axis in acute stroke. Relation to acute confusional state, extent of brain damage, and clinical outcome. Stroke. 1994;25(6):1105-8. (Pubitemid 24164746)
34. Johansson A, Olsson T, Carlberg B, Karlsson K, Fagerlund M. Hypercortisolism after stroke - partly cytokine-mediated? J Neurol Sci. 1997;147(1):43-7.
35. Slowik A, Turaj W, Pankiewicz J, Dziedzic T, Szermer P, Szczudlik A. Hypercortisolemia in acute stroke is related to the inflammatory response. J Neurol Sci. 2002;196(1-2):27-32. (Pubitemid 34311536)
36. Johansson A, Ahren B, Nasman B, Carlstrom K, Olsson T. Cortisol axis abnormalities early after stroke - relationships to cytokines and leptin. J Intern Med. 2000;247(2):179-87. (Pubitemid 30108351)
37. Sapolsky RM. Stress, Glucocorticoids, and Damage to the Nervous System: The Current State of Confusion. Stress. 1996;1(1):1-19.
38. Joynt RJ, Feibel JH, Sladek CM. Antidiuretic hormone levels in stroke patients. Ann Neurol. 1981;9(2):182-4. (Pubitemid 11191198)
39. Barreca T, Gandolfo C, Corsini G, Del Sette M, Cataldi A, Rolandi E, et al. Evaluation of the secretory pattern of plasma arginine vasopressin in stroke patients. Cerebrovasc Dis. 2001;11(2):113-8. (Pubitemid 32171170)
40. Katan M, Fluri F, Morgenthaler NG, Schuetz P, Zweifel C, Bingisser R, et al. Copeptin: a novel, independent prognostic marker in patients with ischemic stroke. Ann Neurol. 2009;66(6):799-808.
41. de Kruif MD, Lemaire LC, Giebelen IA, Struck J, Morgenthaler NG, Papassotiriou J, et al. The influence of corticosteroids on the release of novel biomarkers in human endotoxemia. Intensive Care Med. 2008;34(3):518-22. (Pubitemid 351623033)
42. Bhandari SS, Loke I, Davies JE, Squire IB, Struck J, Ng LL. Gender and renal function influence plasma levels of copeptin in healthy individuals. Clin Sci. (Lond) 2009;116(3):257-63.
43. Christ-Crain M, Muller B. Procalcitonin in bacterial infections - hype, hope, more or less? Swiss Med Wkly. 2005;135(31-32):451-60. (Pubitemid 41376648)
44. Marshall JC. Biomarkers of Sepsis. Curr Infect Dis Rep. 2006;8(5):351-7. (Pubitemid 44445708)
45. G. M. De Marchis, M. Katan, A. Weck, H. P. Mattle, C. Breckenfeld, Ph. Schütz, Ch. Foerch, et al. Validation of Copeptin as prognostic marker in ischemic stroke. Abstract; Meeting of the European Neurological Society 2010.