Feasibility of a closed-system cell processor (ACP215) for automated preparation of washed platelet concentrates

Vox Sanguinis

Volumn 102, Issue 2, 2012, Pages 110-115

  Oikawa, S ^a   Sasaki, D ^a   Kikuchi, M ^a   Sawamura, Y ^a   Itoh, T ^a  

^a Japanese Red Cross Miyagi Blood Center   (Japan)

Author keywords

ACP215; Automated preparation; Febrile non haemolytic transfusion reaction; M sol; Platelet washing; Washed platelet concentrates

Indexed keywords

GLUCOSE; PADGEM PROTEIN; PLASMA PROTEIN; THROMBOCYTE CONCENTRATE;

ACP215 CLOSED SYSTEM CELL PROCESSOR; APHERESIS; ARTICLE; FEASIBILITY STUDY; MEDICAL DEVICE; PH; PLATELET WASHING; PRIORITY JOURNAL; PROCEDURES CONCERNING CELLS; PROTEIN EXPRESSION; THROMBOCYTE; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT; THROMBOCYTE VOLUME;

AUTOMATION, LABORATORY; BLOOD COMPONENT REMOVAL; BLOOD PLATELETS; BLOOD PROTEINS; FEASIBILITY STUDIES; HUMANS; PLATELET ACTIVATION;

EID: 84856012900     PISSN: 00429007     EISSN: 14230410     Source Type: Journal    
DOI: 10.1111/j.1423-0410.2011.01520.x     Document Type: Article

References (23)

1. Gulliksson H: Additive solutions for the storage of platelets for transfusion. Transfus Med 2000; 10:257-264.
2. Hirayama J, Azuma H, Fujihara M, et al.: Storage of platelets in a novel additive solution (M-sol), which is prepared by mixing solutions approved for clinical use that are not especially for platelet storage. Transfusion 2007; 47:960-965.
3. Hirayama J, Azuma H, Fujihara M, et al.: Comparison between in vitro qualities of platelets washed with commercially available additive solutions and those washed with M-sol. Vox Sang 2010; 99:131-135.
4. Japan Society of Transfusion Medicine and Cell Therapy. Indication guidance for washed and replaced platelets and their preparation (Version II). Available from: (Accessed 4 March 2011).
5. Ringwald J, Althoff F, Zimmermann R, et al.: Washing platelets with new additive solutions: aspects on the in vitro quality after 48hours of storage. Transfusion 2006; 46:236-243.
6. Shimizu T, Shibata K, Kora S: Plasma-depleted platelet concentrates prepared with a new washing solution. Vox Sang 1993; 64:19-23.
7. Schoenfeld H, Muhm M, Doepfmer U, et al.: Platelet activity in washed platelet concentrates. Anesth Analg 2004; 99:17-20.
8. Kalmin ND, Brown DJ: Platelet washing with a blood cell processor. Transfusion 1982; 22:125-127.
9. Buck SA, Kickler TS, McGuire M, et al.: The utility of platelet washing using an automated procedure for severe platelet allergic reactions. Transfusion 1987; 27:391-393.
10. Vesilind GW, Simpson MB, Shifman MA, et al.: Evaluation of a centrifugal blood cell processor for washing platelet concentrates. Transfusion 1988; 28:46-51.
11. Pineda AA, Zylstra VW, Clare DE, et al.: Viability and functional integrity of washed platelets. Transfusion 1989; 29:524-527.
12. Kelley WE, Edelman BB, Drachenberg CB, et al.: Washing platelets in neutral, calcium-free, Ringer's acetate. Transfusion 2009; 49:1917-1923.
13. Veeraputhiran M, Ware J, Dent J, et al.: A comparison of washed and volume-reduced platelets with respect to platelet activation, aggregation, and plasma protein removal. Transfusion 2010; 51:1030-1036.
14. Valeri CR, Ragno G, Pivacek LE, et al.: A multicenter study of in vitro and in vivo values in human RBCs frozen with 40-percent (wt/vol) glycerol and stored after deglycerolization for 15days at 4°C in AS-3: assessment of RBC processing in the ACP 215. Transfusion 2001; 41:933-939.
15. Grabmer C, Holmberg J, Popovsky M, et al.: Up to 21-day banked red blood cells collected by apheresis and stored for 14days after automated wash at different times of storage. Vox Sang 2006; 90:40-44.
16. VandenBroeke T, Dumont LJ, Hunter S, et al.: Platelet storage solution effects on the accuracy of laboratory tests for platelet function: a multi-laboratory study. Vox Sang 2004; 86:183-188.
17. Holme S, Moroff G, Murphy S: A multi-laboratory evaluation of in vitro platelet assays: the tests for extent of shape change and response to hypotonic shock. Biomedical Excellence for Safer Transfusion Working Party of the International Society of Blood Transfusion. Transfusion 1998; 38:31-40.
18. Hagberg IA, Lyberg T: Blood platelet activation evaluated by flow cytometry: optimised methods for clinical studies. Platelets 2000; 11:137-150.
19. Curvers J, De Wildt-Eggen J, Heeremans J, et al.: Flow cytometric measurement of CD62P (P-selectin) expression on platelets: a multicenter optimization and standardization effort. Transfusion 2008; 48:1439-1446.
20. Azuma H, Hirayama J, Akino M, et al.: Reduction in adverse reactions to platelets by the removal of plasma supernatant and resuspension in a new additive solution (M-sol). Transfusion 2009; 49:214-218.
21. Zilber M, Friedman Z, Shapiro H, et al.: The effect of plasma depletion of platelet concentrates on platelet aggregation and phosphatidylserine expression. Clin Appl Thromb Hemost 2003; 9:39-44.
22. Leytin V, Allen DJ, Gwozdz A, et al.: Role of platelet surface glycoprotein Ibα and P-selectin in the clearance of transfused platelet concentrates. Transfusion 2004; 44:1487-1495.
23. Edenbrandt CM, Murphy S: Adenine and guanine nucleotide metabolism during platelet storage at 22 degrees C. Blood 1990; 76:1884-1892.