Vulvovaginal myofibroblastoma: Expanding the morphological and immunohistochemical spectrum. A clinicopathologic study of 10 cases

Human Pathology

Volumn 43, Issue 2, 2012, Pages 243-253

  Magro, Gaetano ^a   Caltabiano, Rosario ^a   Kacerovská, Denisa ^b   Vecchio, Giada Maria ^a   Kazakov, Dmitry ^b   Michal, Michal ^b  

^a UNIVERSITY OF CATANIA   (Italy)

^b CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Immunohistochemistry; Mammary type myofibroblastoma; Vulvovaginal myofibroblastoma

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; B CELL LYMPHOMA 2 CD10; CD34 ANTIGEN; CD99 ANTIGEN; COLLAGEN; DESMIN; ESTROGEN RECEPTOR; PROGESTERONE RECEPTOR; PROTEIN BCL 2; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; VIMENTIN;

ADULT; AGED; ARTICLE; BREAST TUMOR; CANCER MORPHOLOGY; CELL STRUCTURE; CLINICAL ARTICLE; CONNECTIVE TISSUE TUMOR; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; FEMALE; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HYALINE DEGENERATION; IMMUNOHISTOCHEMISTRY; MAMMARY MYOFIBROBLASTOMA; MITOSIS; PATHOPHYSIOLOGY; SCLEROSIS; SERTOLI CELL TUMOR; SPINDLE CELL; TUMOR CELL; TUMOR LOCALIZATION; TUMOR VOLUME; VAGINA; VAGINA TUMOR; VULVA TUMOR; VULVOVAGINAL MYOFIBROBLASTOMA;

ADULT; AGED; ANTIGENS, CD; CELL ADHESION MOLECULES; DESMIN; FEMALE; HUMANS; MIDDLE AGED; NEOPLASMS, MUSCLE TISSUE; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL; VAGINAL NEOPLASMS; VIMENTIN; VULVAR NEOPLASMS;

EID: 84856011054     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2011.04.027     Document Type: Article

References (31)

1. R. Ganesan, W.G. McCluggage, and L. Hirschowitz Superficial myofibroblastoma of the lower female genital tract: report of a series including tumors with a vulval location Histopathology 46 2005 137 143 (Pubitemid 40293011)
2. W.B. Laskin, J.F. Fetsch, and F.A. Tavassoli Superficial cervicovaginal myofibroblastoma: fourteen cases of a distinctive mesenchymal tumor arising from the specialized subepithelial stroma of the lower female genital tract Hum Pathol 32 2001 715 725 (Pubitemid 32726896)
3. C.J. Stewart, B. Amanuel, and B.A. Brennan Superficial cervicovaginal myofibroblastoma: a report of five cases Pathology 37 2005 144 148 (Pubitemid 40593406)
4. W.B. Laskin, J.F. Fetsch, and F.A. Tavassoli Angiomyofibroblastoma of the female genital tract: analysis of 17 cases including a lipomatous variant Hum Pathol 28 1997 1046 1055 (Pubitemid 27388106)
5. U. Flucke, J. Han, and J.H. van Krieken Cellular angiofibroma: analysis of 25 cases emphasizing its relationship to spindle cell lipoma and mammary-type myofibroblastoma Mod Pathol 24 2011 82 89
6. Y. Iwasa, and C.D.M. Fletcher Cellular angiofibroma: clinicopathologic and immunhistochemical analysis of 51 cases Am J Surg Pathol 28 2004 1426 1435 (Pubitemid 39425509)
7. W.G. McCluggage Recent developments in vulvovaginal pathology Histopathology 54 2009 156 173
8. G. Magro, M. Michal, and M. Bisceglia Benign spindle cell tumors of the mammary stroma: diagnostic criteria, classification, and histogenesis Pathol Res Pract 197 2001 453 466 (Pubitemid 32677791)
9. G. Magro, M. Bisceglia, and M. Michal Spindle cell lipoma-like tumor, solitary fibrous tumor and myofibroblastoma of the breast: a clinicopathological analysis of 13 cases in favor of a unifying histologic concept Virchows Arch 440 2002 249 260 (Pubitemid 34230728)
10. G. Magro Mammary myofibroblastoma. A tumor with a wide morphologic spectrum Arch Pathol Lab Med 132 2008 1813 1820
11. M.E. McMenamin, and C.D. Fletcher Mammary-type myofibroblastoma of soft tissue: a tumor closely related to spindle cell lipoma Am J Surg Pathol 25 2001 1022 1029 (Pubitemid 32685899)
12. G.B. Diwadkar, and M.D. Barber Vulvar mammary-type myofibroblastoma. A case report J Reprod Med 54 2009 404 406
13. M.R. Nucci, and C.D.M. Fletcher Vulvovaginal soft tissue tumors Histopathology 36 2000 97 108
14. W.G. McCluggage, R. Ganesan, and L. Hirschowitz Cellular angiofibroma and related fibromatous lesions of the vulva: report of a series of cases with a morphological spectrum wider than previously described Histopathology 45 2004 360 368 (Pubitemid 39430641)
15. M.R. Nucci, S.R. Granter, and C.D.M. Fletcher Cellular angiofibroma: a benign neoplasm distinct from angiomyofibroblastoma and spindle cell lipoma Am J Surg Pathol 21 1997 636 644 (Pubitemid 27265750)
16. M. Hameed, K. Clarke, and H.Z. Amer Cellular angiofibroma is genetically similar to spindle cell lipoma: a case report Cancer Genet Cytogenet 177 2007 131 134 (Pubitemid 47374280)
17. F. Maggiani, M. Debiec-Rychter, and M. Vanbockrijck Cellular angiofibroma: another mesenchymal tumor with 13q14 involvement, suggesting a link with spindle cell lipoma and (extra)-mammary myofibroblastoma Histopathology 51 2007 410 412 (Pubitemid 47301613)
18. F. Maggiani, M. Debiec-Rychter, and G. Verbeeck Extramammary myofibroblastoma is genetically related to spindle cell lipoma Virchows Arch 449 2006 244 247
19. P. Pauwels, R. Sciot, and F. Croiset Myofibroblastoma of the breast: genetic link with spindle cell lipoma J Pathol 191 2000 282 285 (Pubitemid 30441252)
20. E. Chen, and C.D.M. Fletcher Cellular angiofibroma with atypia and sarcomatous transformation: a clinicopathologic analysis of 13 cases Am J Surg Pathol 34 2010 707 714
21. D.H. Kandil, M. Kida, and D.R. Laub Sarcomatous transformation in a cellular angiofibroma: a case report J Clin Pathol 62 2009 945 947
22. O.J. Biedrzycki, N. Singh, and H. Habeeb Solitary fibrous tumor of the female genital tract a case report and review of the literature Int J Gynecol Pathol 26 2007 259 264 (Pubitemid 46986059)
23. O.J. Biedrycki, N. Singh, and A. Faruqi Nodular fasciitis of the vulva with an unusually long clinical history; the importance of making this unexpected diagnosis in such an unusual site Histopathology 51 2007 547 550 (Pubitemid 47437822)
24. M. Meenakshi, and W.G. McCluggage Myoepithelial neoplasms involving the vulva and vagina: report of 4 cases Hum Pathol 40 2009 1747 1753
25. G.P. Nielsen, and R.H. Young Fibromatosis of soft tissue type involving the female genital tract: a report of two cases Int J Gynecol Pathol 16 1997 383 386 (Pubitemid 27413530)
26. J.X. O'Connell, R.H. Young, and G.P. Nielsen Nodular fasciitis of the vulva: a study of six cases and literature review Int J Gynecol Pathol 16 1997 117 123 (Pubitemid 27231291)
27. J.S. Reis-Filho, F. Milanezi, and M.F. Soares Intradermal spindle cell/pleomorphic lipoma of the vulva: case report and review of the literature J Cutan Pathol 29 2002 59 62 (Pubitemid 34155172)
28. E.W. Sonnedecker, R.J. Cohen, and L. Dreyer Neuroma of the vulva. A case report J Reprod Med 38 1993 33 36
29. P.F. Venter, G.F. Rohm, and C.F. Slabber Giant neurofibromas of the labia Obstet Gynecol 57 1981 128 130 (Pubitemid 11213563)
30. G. Magro, R. Caltabiano, and A. Di Cataldo CD10 is expressed by mammary myofibroblastoma and spindle cell lipoma of soft tissue: an additional evidence of their histogenetic linking Virchows Arch 450 2007 727 728 (Pubitemid 46986236)
31. G. Magro Stromal tumors of the lower female genital tract: histogenetic, morphological and immunohistochemical similarities with the "benign spindle cell tumors of the mammary stroma" Pathol Res Pract 203 2007 827 829 (Pubitemid 47543533)