Mice with mutations in fas and fas ligand demonstrate increased herpetic stromal keratitis following corneal infection with HSV-1

Journal of Immunology

Volumn 188, Issue 2, 2012, Pages 793-799

  Morris, Jessica E ^a   Zobell, Stephanie ^b   Yin, Xiao Tang ^b   Zakeri, Hamideh ^b,c   Summers, Bretton C ^a   Leib, David A ^a,d   Stuart, Patrick M ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Sigma Aldrich Co   (United States)

^d DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; CD45 ANTIGEN; CD8ALPHA ANTIGEN; CELL ANTIGEN; CELL RECEPTOR; F40/80 ANTIGEN; FAS ANTIGEN; FAS LIGAND; PROTEIN GR 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ANTIGEN FUNCTION; ARTICLE; BLEPHARITIS; BONE MARROW CELL; CD4 CD8 RATIO; CELL INFILTRATION; CELL ISOLATION; CONTROLLED STUDY; CORNEA NEOVASCULARIZATION; CORNEA OPACITY; DISEASE ASSOCIATION; DISEASE SEVERITY; GENOTYPE; HERPES SIMPLEX KERATITIS; HERPES SIMPLEX VIRUS 1; INFLAMMATORY CELL; LYMPHOCYTE FUNCTION; MORTALITY; MOUSE; MUTAGENESIS; NONHUMAN; PHENOTYPE; PRIMARY INFECTION; PRIORITY JOURNAL; RECURRENT DISEASE; STRAIN DIFFERENCE; T LYMPHOCYTE; TRIGEMINUS GANGLION; VIRUS REPLICATION; WILD TYPE;

ANIMALS; ANTIGENS, CD95; BONE MARROW TRANSPLANTATION; DISEASE RESISTANCE; FAS LIGAND PROTEIN; GENE EXPRESSION REGULATION, VIRAL; GENETIC PREDISPOSITION TO DISEASE; HERPESVIRUS 1, HUMAN; INFLAMMATION; KERATITIS, HERPETIC; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, MUTANT STRAINS; RADIATION CHIMERA; SEVERITY OF ILLNESS INDEX; STROMAL CELLS; UP-REGULATION; VIRAL LOAD;

EID: 84856002588     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1102251     Document Type: Article

References (36)

1. Pepose, J. S., D. A. Leib, P. M. Stuart, and E. L. Easty. 1996. Herpes simplex virus diseases: anterior segment of the eye. In Ocular Infection and Immunity. J. S. Pepose, G. A. N. Holland, and K. R. Wilhelmus, eds. Mosby, St. Louis, MO, p. 905-932.
2. Thomas, J., S. Gangappa, S. Kanangat, and B. T. Rouse. 1997. On the essential involvement of neutrophils in the immunopathologic disease: herpetic stromal keratitis. J. Immunol. 158: 1383-1391. (Pubitemid 127469965)
3. Maertzdorf, J., G. M. Verjans, L. Remeijer, A. van der Kooi, and A. D. Osterhaus. 2003. Restricted T cell receptor beta-chain variable region protein use by cornea-derived CD4+ and CD8+ herpes simplex virus-specific T cells in patients with herpetic stromal keratitis. J. Infect. Dis. 187: 550-558. (Pubitemid 36250018)
4. Divito, S. J., and R. L. Hendricks. 2008. Activated inflammatory infiltrate in HSV-1-infected corneas without herpes stromal keratitis. Invest. Ophthalmol. Vis. Sci. 49: 1488-1495.
5. Denniston, A. K., S. H. Kottoor, I. Khan, K. Oswal, G. P. Williams, J. Abbott, G. R. Wallace, M. Salmon, S. Rauz, P. I. Murray, and S. J. Curnow. 2011. Endogenous cortisol and TGF-beta in human aqueous humor contribute to ocular immune privilege by regulating dendritic cell function. J. Immunol. 186: 305-311.
6. Cursiefen, C. 2007. Immune privilege and angiogenic privilege of the cornea. Chem. Immunol. Allergy 92: 50-57. (Pubitemid 47096896)
7. Koevary, S. B. 2000. Ocular immune privilege: a review. Clin. Eye Vis. Care 12: 97-106. (Pubitemid 32008589)
8. Griffith, T. S., T. Brunner, S. M. Fletcher, D. R. Green, and T. A. Ferguson. 1995. Fas ligand-induced apoptosis as a mechanism of immune privilege. Science 270: 1189-1192.
9. Griffith, T. S., X. Yu, J. M. Herndon, D. R. Green, and T. A. Ferguson. 1996. CD95-induced apoptosis of lymphocytes in an immune privileged site induces immunological tolerance. Immunity 5: 7-16. (Pubitemid 26254781)
10. Stuart, P. M., T. S. Griffith, N. Usui, J. S. Pepose, X. Yu, and T. A. Ferguson. 1997. CD95 ligand (FasL)-induced apoptosis is necessary for corneal allograft survival. J. Clin. Invest. 99: 396-402. (Pubitemid 27414796)
11. Osawa, H., K. Maruyama, and J. W. Streilein. 2004. CD95 ligand expression on corneal epithelium and endothelium influences the fates of orthotopic and heterotopic corneal allografts in mice. Invest. Ophthalmol. Vis. Sci. 45: 1908-1915. (Pubitemid 38868989)
12. Kaplan, H. J., M. A. Leibole, T. Tezel, and T. A. Ferguson. 1999. Fas ligand (CD95 ligand) controls angiogenesis beneath the retina. Nat. Med. 5: 292-297. (Pubitemid 29124364)
13. Volpert, O. V., T. Zaichuk, W. Zhou, F. Reiher, T. A. Ferguson, P. M. Stuart, M. Asif, and N. P. Bouck. 2002. Inducer-stimulated Fas targets activated endothelium for destruction by anti-angiogenic thrombospondin-1 and pigment epithelium-derived factor. Nat. Med. 8: 349-357. (Pubitemid 34407029)
14. Stuart, P. M., F. Pan, S. Plambeck, and T. A. Ferguson. 2003. FasL-Fas interactions regulate neovascularization in the cornea. Invest. Ophthalmol. Vis. Sci. 44: 93-98. (Pubitemid 36134260)
15. Richardson, B. C., N. D. Lalwani, K. J. Johnson, and R. M. Marks. 1994. Fas ligation triggers apoptosis in macrophages but not endothelial cells. Eur. J. Immunol. 24: 2640-2645. (Pubitemid 24342177)
16. Laurence, J., D. Mitra, M. Steiner, L. Staiano-Coico, and E. Jaffe. 1996. Plasma from patients with idiopathic and human immunodeficiency virus-associated thrombotic thrombocytopenic purpura induces apoptosis in microvascular endothelial cells. Blood 87: 3245-3254.
17. Suhara, T., K. Fukuo, T. Sugimoto, S. Morimoto, T. Nakahashi, S. Hata, M. Shimizu, and T. Ogihara. 1998. Hydrogen peroxide induces up-regulation of Fas in human endothelial cells. J. Immunol. 160: 4042-4047. (Pubitemid 28176114)
18. Keadle, T. L., L. A. Morrison, J. L. Morris, J. S. Pepose, and P. M. Stuart. 2002. Therapeutic immunization with a virion host shutoff-defective, replication-incompetent herpes simplex virus type 1 strain limits recurrent herpetic ocular infection. J. Virol. 76: 3615-3625. (Pubitemid 34250526)
19. Stuart, P. M., X. T. Yin, S. Plambeck, F. Pan, and T. A. Ferguson. 2005. The role of Fas ligand as an effector molecule in corneal graft rejection. Eur. J. Immunol. 35: 2591-2597. (Pubitemid 41404042)
20. Herndon, J. M., P. M. Stuart, and T. A. Ferguson. 2005. Peripheral deletion of antigen-specific T cells leads to long-term tolerance mediated by CD8+ cytotoxic cells. J. Immunol. 174: 4098-4104. (Pubitemid 40395986)
21. Stuart, P. M., B. Summers, J. E. Morris, L. A. Morrison, and D. A. Leib. 2004. CD8(+) T cells control corneal disease following ocular infection with herpes simplex virus type 1. J. Gen. Virol. 85: 2055-2063. (Pubitemid 39023285)
22. Smith, T. J., C. E. Ackland-Berglund, and D. A. Leib. 2000. Herpes simplex virus virion host shutoff (vhs) activity alters periocular disease in mice. J. Virol. 74: 3598-3604. (Pubitemid 30180303)
23. Geiss, B. J., T. J. Smith, D. A. Leib, and L. A. Morrison. 2000. Disruption of virion host shutoff activity improves the immunogenicity and protective capacity of a replication-incompetent herpes simplex virus type 1 vaccine strain. J. Virol. 74: 11137-11144. (Pubitemid 32223980)
24. Nguyen, Q. D., H. S. Uy, A. Merchant, C. A. Medina, S. Baltatzis, T. Zhao, Z. S. Zhao, H. Cantor, and C. S. Foster. 2001. Effect of Fas and Fas ligand deficiency in resistance of C57BL/6 mice to HSV-1 keratitis and chorioretinitis. Invest. Ophthalmol. Vis. Sci. 42: 2505-2509. (Pubitemid 32954855)
25. Karray, S., C. Kress, S. Cuvellier, C. Hue-Beauvais, D. Damotte, C. Babinet, and M. Lévi-Strauss. 2004. Complete loss of Fas ligand gene causes massive lymphoproliferation and early death, indicating a residual activity of gld allele. J. Immunol. 172: 2118-2125. (Pubitemid 38182357)
26. Laouar, Y., and S. Ezine. 1994. In vivo CD4+ lymph node T cells from lpr mice generate CD4-CD8-B220+TCR-β low cells. J. Immunol. 153: 3948-3955.
27. Ishikawa, T., H. Yamada, A. Oyamada, F. Goshima, Y. Nishiyama, and Y. Yoshikai. 2009. Protective role of Fas-FasL signaling in lethal infection with herpes simplex virus type 2 in mice. J. Virol. 83: 11777-11783.
28. Yamagami, S., H. Kawashima, T. Tsuru, H. Yamagami, N. Kayagaki, H. Yagita, K. Okumura, and D. S. Gregerson. 1997. Role of Fas-Fas ligand interactions in the immunorejection of allogeneic mouse corneal transplants. Transplantation 64: 1107-1111. (Pubitemid 27467933)
29. Dobbs, M. E., J. E. Strasser, C. F. Chu, C. Chalk, and G. N. Milligan. 2005. Clearance of herpes simplex virus type 2 by CD8+ T cells requires gamma interferon and either perforin- or Fas-mediated cytolytic mechanisms. J. Virol. 79: 14546-14554. (Pubitemid 41636253)
30. Rouvier, E., M.-F. Luciani, and P. Golstein. 1993. Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity. J. Exp. Med. 177: 195-200. (Pubitemid 23008100)
31. Liu, Z. X., S. Govindarajan, S. Okamoto, and G. Dennert. 2001. Fas-mediated apoptosis causes elimination of virus-specific cytotoxic T cells in the virus-infected liver. J. Immunol. 166: 3035-3041. (Pubitemid 33120947)
32. Deshpande, S. P., M. Zheng, M. Daheshia, and B. T. Rouse. 2000. Pathogenesis of herpes simplex virus-induced ocular immunoinflammatory lesions in B-cell-deficient mice. J. Virol. 74: 3517-3524. (Pubitemid 30180293)
33. Hu, K., J. Dou, F. Yu, X. He, X. Yuan, Y. Wang, C. Liu, and N. Gu. 2011. An ocular mucosal administration of nanoparticles containing DNA vaccine pRSC-gD-IL-21 confers protection against mucosal challenge with herpes simplex virus type 1 in mice. Vaccine 29: 1455-1462.
34. Mitsiades, N., W. H. Yu, V. Poulaki, M. Tsokos, and I. Stamenkovic. 2001. Matrix metalloproteinase-7-mediated cleavage of Fas ligand protects tumor cells from chemotherapeutic drug cytotoxicity. Cancer Res. 61: 577-581. (Pubitemid 32128617)
35. Stuart, P. M., F. Pan, X. T. Yin, Z. Haskova, S. Plambeck, and T. A. Ferguson. 2004. Effect of metalloprotease inhibitors on corneal allograft survival. Invest. Ophthalmol. Vis. Sci. 45: 1169-1173. (Pubitemid 38869023)
36. Roychoudhury, J., J. M. Herndon, J. Yin, R. S. Apte, and T. A. Ferguson. 2010. Targeting immune privilege to prevent pathogenic neovascularization. Invest. Ophthalmol. Vis. Sci. 51: 3560-3566.