Decreased xanthine oxidoreductase (XOR) is associated with a worse prognosis in patients with serous ovarian carcinoma

Gynecologic Oncology

Volumn 124, Issue 2, 2012, Pages 311-318

  Linder, Nina ^a   Bützow, Ralf ^b   Lassus, Heini ^b   Lundin, Mikael ^a   Lundin, Johan ^a,c  

^a UNIVERSITY OF HELSINKI   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Ovarian cancer; Prognosis; Serous histology; Survival analysis; Xanthine oxidoreductase; XOR

Indexed keywords

KI 67 ANTIGEN; PROTEIN P53; XANTHINE OXIDASE;

ADULT; AGED; ARTICLE; CANCER STAGING; CANCER SURGERY; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; OUTCOME ASSESSMENT; OVARY CARCINOMA; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SURVIVAL; TISSUE MICROARRAY; TUMOR VOLUME;

CYSTADENOCARCINOMA, SEROUS; CYTOPLASM; DOWN-REGULATION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MICROARRAY ANALYSIS; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM STAGING; OVARIAN NEOPLASMS; PROGNOSIS; SURVIVAL RATE; XANTHINE DEHYDROGENASE;

EID: 84855989938     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2011.10.026     Document Type: Article

References (32)

1. E.M. Rytkonen, R. Halila, M. Laan, M. Saksela, O.P. Kallioniemi, and A. Palotie The human gene for xanthine dehydrogenase (XDH) is localized on chromosome band 2q22 Cytogenet Cell Genet 68 1-2 1995 61 63 (Pubitemid 24335381)
2. J. Lin, P. Xu, P. LaVallee, and J.R. Hoidal Identification of proteins binding to E-Box/Ku86 sites and function of the tumor suppressor SAFB1 in transcriptional regulation of the human xanthine oxidoreductase gene J Biol Chem 283 44 Oct 31 2008 29681 29689
3. N. Linder, J. Rapola, and K.O. Raivio Cellular expression of xanthine oxidoreductase protein in normal human tissues Lab Invest 79 8 Aug 1999 967 974 (Pubitemid 29400141)
4. C. Vorbach, A. Scriven, and M.R. Capecchi The housekeeping gene xanthine oxidoreductase is necessary for milk fat droplet enveloping and secretion: gene sharing in the lactating mammary gland Genes Dev 16 24 Dec 15 2002 3223 3235 (Pubitemid 36025975)
5. H. Ota, S. Igarashi, and T. Tanaka Xanthine oxidase in eutopic and ectopic endometrium in endometriosis and adenomyosis Fertil Steril 75 4 Apr 2001 785 790 (Pubitemid 32273516)
6. Y. Margolin, and H.R. Behrman Xanthine oxidase and dehydrogenase activities in rat ovarian tissues Am J Physiol 262 2 Pt 1 Feb 1992 E173 E178
7. E. Garattini, R. Mendel, M.J. Romao, R. Wright, and M. Terao Mammalian molybdo-flavoenzymes, an expanding family of proteins: structure, genetics, regulation, function and pathophysiology Biochem J 372 Pt 1 May 15 2003 15 32 (Pubitemid 36609603)
8. M.A. Fini, D. Orchard-Webb, B. Kosmider, J.D. Amon, R. Kelland, and G. Shibao Migratory activity of human breast cancer cells is modulated by differential expression of xanthine oxidoreductase J Cell Biochem 105 4 Nov 1 2008 1008 1026
9. N. Linder, E. Martelin, R. Lapatto, and K.O. Raivio Posttranslational inactivation of human xanthine oxidoreductase by oxygen under standard cell culture conditions Am J Physiol Cell Physiol 285 1 Jul 2003 C48 C55
10. L. Terada, D. Guidot, J. Leff, I. Willingham, M. Hanley, and D. Piermattei Hypoxia injures endothelial cells by increasing endogenous xanthine oxidase activity Proc Natl Acad Sci 89 1992 3362 3366
11. S. Gibbings, N.D. Elkins, H. Fitzgerald, J. Tiao, M.E. Weyman, and G. Shibao Xanthine oxidoreductase promotes the inflammatory state of mononuclear phagocytes through effects on chemokine expression, PPAR{gamma} sumoylation, and HIF-1{alpha} J Biol Chem 286 2 Jan 14 2011 961 975
12. M. Terao, G. Cazzaniga, P. Ghezzi, M. Bianchi, F. Falciani, and P. Perani Molecular cloning of a cDNA coding for mouse liver xanthine dehydrogenase. Regulation of its transcript by interferons in vivo Biochem J 283 Pt 3 May 1 1992 863 870
13. N. Linder, J. Lundin, J. Isola, M. Lundin, K.O. Raivio, and H. Joensuu Down-regulated xanthine oxidoreductase is a feature of aggressive breast cancer Clin Cancer Res 11 12 Jun 15 2005 4372 4381 (Pubitemid 40825626)
14. N. Linder, E. Martelin, M. Lundin, J. Louhimo, S. Nordling, and C. Haglund Xanthine oxidoreductase - clinical significance in colorectal cancer and in vitro expression of the protein in human colon cancer cells Eur J Cancer 45 4 Mar 2009 648 655
15. N. Linder, C. Haglund, M. Lundin, S. Nordling, A. Ristimaki, and A. Kokkola Decreased xanthine oxidoreductase is a predictor of poor prognosis in early-stage gastric cancer J Clin Pathol 59 9 Sep 2006 965 971 (Pubitemid 44422852)
16. A.W. Kim, M. Batus, R. Myint, M.J. Fidler, S. Basu, and P. Bonomi Prognostic value of xanthine oxidoreductase expression in patients with non-small cell lung cancer Lung Cancer 71 2 Feb 2011 186 190
17. R.T. Marquez, K.A. Baggerly, A.P. Patterson, J. Liu, R. Broaddus, and M. Frumovitz Patterns of gene expression in different histotypes of epithelial ovarian cancer correlate with those in normal fallopian tube, endometrium, and colon Clin Cancer Res 11 17 Sep 1 2005 6116 6126 (Pubitemid 41262937)
18. M. Kobel, S.E. Kalloger, N. Boyd, S. McKinney, E. Mehl, and C. Palmer Ovarian carcinoma subtypes are different diseases: implications for biomarker studies PLoS Med 5 12 Dec 2 2008 e232
19. Epidemiology and End Results: SEER cancer Statistics Review, 1975-2003 [database on the Internet] http://seer.cancer.gov/csr/1975-2003/3 2006
20. D.L. Clarke-Pearson Clinical practice. Screening for ovarian cancer N Engl J Med 361 2 Jul 9 2009 170 177
21. R.C. Young, L.A. Walton, S.S. Ellenberg, H.D. Homesley, G.D. Wilbanks, and D.G. Decker Adjuvant therapy in stage I and stage II epithelial ovarian cancer. Results of two prospective randomized trials N Engl J Med 322 15 Apr 12 1990 1021 1027 (Pubitemid 20146659)
22. A.B. Miller, B. Hoogstraten, M. Staquet, and A. Winkler Reporting results of cancer treatment Cancer 47 1 Jan 1 1981 207 214 (Pubitemid 11167383)
23. J.A. Bridgewater, A.E. Nelstrop, G.J. Rustin, M.E. Gore, W.P. McGuire, and W.J. Hoskins Comparison of standard and CA-125 response criteria in patients with epithelial ovarian cancer treated with platinum or paclitaxel J Clin Oncol 17 2 Feb 1999 501 508 (Pubitemid 29075234)
24. J. Kononen, L. Bubendorf, A. Kallioniemi, M. Barlund, P. Schraml, and S. Leighton Tissue microarrays for high-throughput molecular profiling of tumor specimens Nat Med 4 7 Jul 1998 844 847 (Pubitemid 28331029)
25. A. Sarnesto, N. Linder, and K.O. Raivio Organ distribution and molecular forms of human xanthine dehydrogenase/xanthine oxidase protein Lab Invest 74 1 Jan 1996 48 56 (Pubitemid 26041008)
26. H. Lassus, A. Leminen, J. Lundin, P. Lehtovirta, and R. Butzow Distinct subtypes of serous ovarian carcinoma identified by p53 determination Gynecol Oncol 91 3 Dec 2003 504 512 (Pubitemid 38388142)
27. H. Lassus, A. Leminen, A. Vayrynen, G.J. Cheng, J.A. Gustafsson, and J. Isola ERBB2 amplification is superior to protein expression status in predicting patient outcome in serous ovarian carcinoma Gynecol Oncol 92 1 Jan 2004 31 39 (Pubitemid 38147368)
28. T. Ikegami, Y. Natsumeda, and G. Weber Decreased concentration of xanthine dehydrogenase (EC 1.1.1.204) in rat hepatomas Cancer Res 46 8 Aug 1986 3838 3841 (Pubitemid 16075871)
29. N. Prajda, H.P. Morris, and G. Weber Imbalance of purine metabolism in hepatomas of different growth rates as expressed in behavior of xanthine oxidase (EC 1.2.3.2) Cancer Res 36 12 Dec 1976 4639 4646
30. J.L. McManaman, M.C. Neville, and R.M. Wright Mouse mammary gland xanthine oxidoreductase: purification, characterization, and regulation Arch Biochem Biophys 371 2 Nov 15 1999 308 316
31. J.L. McManaman, C.A. Palmer, R.M. Wright, and M.C. Neville Functional regulation of xanthine oxidoreductase expression and localization in the mouse mammary gland: evidence of a role in lipid secretion J Physiol 545 Pt 2 Dec 1 2002 567 579 (Pubitemid 36004390)
32. S.M. Anderson, M.C. Rudolph, J.L. McManaman, and M.C. Neville Key stages in mammary gland development. Secretory activation in the mammary gland: it's not just about milk protein synthesis! Breast Cancer Res 9 1 2007 204