GABAergic neuron deficit as an idiopathic generalized epilepsy mechanism: The role of BRD2 haploinsufficiency in juvenile myoclonic epilepsy

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  Velíšek, Libor ^a,b   Shang, Enyuan ^c   Velíšková, Jana ^a,b   Chachua, Tamar ^a,b   Macchiarulo, Stephania ^b   Maglakelidze, Giorgi ^c,d   Wolgemuth, Debra J ^d   Greenberg, David A ^c,d  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c Columbia University Medical Center ^*  (United States)

^d NewYork Presbyterian Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMATE DECARBOXYLASE 67; GLUTAMIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR; BIOLOGICAL MARKER; BRD2 PROTEIN, MOUSE; PROTEIN SERINE THREONINE KINASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BASAL GANGLION; BRAIN NERVE CELL; BRAIN REGION; BRD2 GENE; CONTROLLED STUDY; CORPUS STRIATUM; DOWN REGULATION; ELECTROENCEPHALOGRAM; FEMALE; GABAERGIC SYSTEM; GENE; GENERALIZED EPILEPSY; HAPLOINSUFFICIENCY; HETEROZYGOTE; HOMOZYGOTE; JUVENILE MYOCLONIC EPILEPSY; MALE; MOUSE; MYOCLONUS EPILEPSY; NEOCORTEX; NONHUMAN; PROTEIN EXPRESSION; SEIZURE THRESHOLD; SEX DIFFERENCE; SUBSTANTIA NIGRA PARS RETICULATA; SUPERIOR COLLICULUS; THALAMUS VENTRAL NUCLEUS; TONIC CLONIC SEIZURE; VIDEORECORDING; ANIMAL; C57BL MOUSE; DISEASE PREDISPOSITION; ELECTROENCEPHALOGRAPHY; GENETICS; HUMAN; METABOLISM; MOUSE MUTANT; PATHOLOGY;

MUS;

ANIMALS; BIOLOGICAL MARKERS; DISEASE SUSCEPTIBILITY; ELECTROENCEPHALOGRAPHY; EPILEPSY, GENERALIZED; FEMALE; GABAERGIC NEURONS; HAPLOINSUFFICIENCY; HETEROZYGOTE; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCLONIC EPILEPSY, JUVENILE; PROTEIN-SERINE-THREONINE KINASES;

EID: 84855987512     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0023656     Document Type: Article

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