Comparison of the efficacy of 5% topical spironolactone gel and placebo in the treatment of mild and moderate acne vulgaris: A randomized controlled trial

Journal of Dermatological Treatment

Volumn 23, Issue 1, 2012, Pages 21-25

  Afzali, Bahare Malek ^a   Yaghoobi, Elena ^a   Yaghoobi, Reza ^b   Bagherani, Nooshin ^b   Dabbagh, Mohammad Ali ^b  

^a ISLAMIC AZAD UNIVERSITY   (Iran)

^b AHVAZ JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Acne vulgaris; Spironolactone; Topical; Treatment

Indexed keywords

PLACEBO; SPIRONOLACTONE;

ACNE VULGARIS; ADOLESCENT; ADULT; ARTICLE; CHILD; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; GEL; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEBUM SECRETION; TREATMENT RESPONSE;

ACNE VULGARIS; ADMINISTRATION, CUTANEOUS; ADOLESCENT; ADULT; ALDOSTERONE ANTAGONISTS; DOUBLE-BLIND METHOD; GELS; HUMANS; SEVERITY OF ILLNESS INDEX; SPIRONOLACTONE; YOUNG ADULT;

EID: 84855986630     PISSN: 09546634     EISSN: 14711753     Source Type: Journal    
DOI: 10.3109/09546634.2010.488260     Document Type: Article

References (9)

1. Poulin Y. Practical approach to the hormonal treatment of acne. J Cutan Med Surg. 2004;8(suppl 4):16-21. (Pubitemid 40898116)
2. Clearihan L. Acne. Myths and management issues. Aust Fam Physician. 2001;30:1039-1044.
3. Kubba R, Bajoj AK, Thappa DM. Principle of topical therapy. Indian J Dermatol Venerol Leprol. 2009;75:526-527.
4. Cunliffe WJ, Bottomley WW. Antiandrogens and acne: A topical approach? Arch Dermatol. 1992;128:1261-1264.
5. Shaw JC. Spironolactone in dermatologic therapy. J Am Acad Dermatol. 1991;24(2 Pt 1):236-243.
6. Shaw JC, Wite LE. Long-term safety of spironolactone in acne: Result of 8-year follow up study. J Cutan Med Surg. 2002;6: 541-545. (Pubitemid 36091499)
7. Berardesca E, Gabba P, Ucci G, Borroni G, Rabbiosi G. Topical spironolactone inhibits dihydrotes testosterone receptors in humans sebaceous glands: An autoradio graphic study in subjects with acne vulgaris. Int J Tissue React. 1988;10:115-119.
8. Rey FO, Valterio C, Locatelli L, Ramelet AA, Felber JP. Lack of endocrine systemic side effects after topical application of spironolactone in man. J Endocrinol Invest. 1988;11:273-278.
9. Califano L, Cannavo S, Siragusa M, Girardi R. Experience in the therapy of acne with topical administration on spironolac-tone as an antiandrogen. Clin Ter. 1990;135:193-199.