Weighted multiple testing correction for correlated tests

Statistics in Medicine

Volumn 31, Issue 4, 2012, Pages 341-352

  Xie, Changchun ^a,b  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

Bonferroni correction; Correlated endpoints; Fixed sequence; Multivariate normal distribution; Weighted multiple testing correction

Indexed keywords

ALPHA EXHAUSTIVE FALLBACK; ANALYTIC METHOD; ARTICLE; BONFERRONI CORRECTION; CLINICAL RESEARCH; CORRELATION ANALYSIS; EFFECT SIZE; FAMILY WISE TYPE I ERROR RATE; FLEXIBLE FIXED SEQUENCE; HOLM PROCEDURE; HYPOTHESIS; INFORMATION PROCESSING; MATHEMATICAL ANALYSIS; METHODOLOGY; PROBABILITY; SIMULATION; WIEN BONFERRONI FIXED SEQUENCE;

CLINICAL TRIALS AS TOPIC; COMPUTER SIMULATION; DATA INTERPRETATION, STATISTICAL; HUMANS; MODELS, STATISTICAL; SOFTWARE;

EID: 84855948541     PISSN: 02776715     EISSN: 10970258     Source Type: Journal    
DOI: 10.1002/sim.4434     Document Type: Article

References (23)

1. Pocock SJ, Geller NL, Tsiatis AA. The analysis of multiple endpoints in clinical trials. Biometrics 1987; 43:487-498.
2. James S. The approximate multinormal probabilities applied to correlated multiple endpoints in clinical trials. Statistics in Medicine 1991; 10:1123-1135.
3. Cheverud JM. A simple correction for multiple comparisons in interval mapping genome scans. Heredity 2001; 87:52-58.
4. Nyholt DR. A simple correction for multiple testing for single-nucleotide polymorphisms in likage disequilibrium with each other. The American Journal of Human Genetics 2004; 74:765-769.
5. Li J, Ji L. Adjusting multiple testing in multilocus analysis using the eigenvalues of a correlation matrix. Heredity 2005; 95:221-227.
6. Moskvina V, Schmidt KM. On Multiple-testing correction in Genome-Wide Association Studies. Genetic Epidemiology 2008; 32:567-573.
7. Conneely KN, Boehnke M. So many correlated tests, so little time! Rapid adjustment of p values for multiple correlated tests. The American Journal of Human Genetics 2007; 81:1158-1168.
8. Leon AC, Heo M, Teres JJ, Morikawa T. Statistical power of multiplicity adjustment strategies for correlated binary endpoints. Statistics in Medicine 2007; 26:1712-1723.
9. Hochberg Y. A sharper Bonferroni procedure for multiple test of significance. Biometrika 1988; 75:800-803.
10. Holm S. A simple sequentially rejective multiple test procedure. Scandinavian Journal of Statistics 1979; 6:65-70.
11. Moyé LA. Alpha calculus in clinical trials: considerations and commentary for the new millennium. Statistics in Medicine 2000; 19:767-779.
12. Moyé LA. P-value interpretation and alpha allocation in clinical trials. Annals of Epidemiology 1998; 8:351-357.
13. Wiens BL. A fixed sequence Bonferroni procedure for testing multiple endpoints. Pharmaceutical Statistics 2003; 2:211-215.
14. Wiens BL, Dmitrienko A. The fallback procedure for evaluating a single family of hypotheses. Journal of Biopharmaceutical Statistics 2005; 15:929-942.
15. Wiens BL, Dmitrienko A. On selecting a multiple comparison procedure for analysis of a clinical trial: fallback, fixed sequence, and related procedures. Statistics in Biopharmaceutical Research 2010; 2:22-32.
16. Huque MF, Alosh M. A flexible fixed-sequence testing method for hierarchically ordered correlated multiple endpoints in clinical trials. Journal of Statistical Planning and Inference 2008; 138:321-335.
17. Westfall PH, Young SS. Resampling-Based Multiple Testing: Examples and Methods for P-Value Adjustment. Wiley: NewYork, 1993.
18. R Development Core Team. R: a language and environment for statistical computing. R Foundation for Statistical Computing, 2010 (available at).
19. Marcus R, Peritz E, Gabriel KR. On closed testing procedures with special reference to ordered analysis of variance. Biometrika 1976; 63:655-660.
20. Genz A. Numerical computation of multivariate normal probabilities. Journal of Computational and Graphical Statistics 1992; 1:141-149.
21. Genz A. Comparison of methods for the computation of multivariate normal probabilities. Computing Science and Statistics 1993; 25:400-405.
22. Genz A, Bretz F, Hothorn T. mvtnorm: multivariate normal and t distribution. R package version 2.12.0 2010 (available at).
23. Higham NJ. Computing the nearest correlation matrix - A problem from finance. IMA Journal of Numerical Analysis 2002; 22(3):329-343.