Crisis in hospital-acquired, healthcare-associated infections

Annual Review of Medicine

Volumn 63, Issue , 2012, Pages 359-371

  Calfee, David P ^a,b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b NEW YORK PRESBYTERIAN HOSPITAL   (United States)

Author keywords

Healthcare epidemiology; Infection control; Nosocomial infection; Patient safety; Prevention

Indexed keywords

ANTIBIOTIC AGENT; CARBAPENEM; CHLORHEXIDINE;

ANTIBIOTIC RESISTANCE; ANTISEPSIS; BLOODSTREAM INFECTION; CATHETER INFECTION; CLEANING; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM DIFFICILE INFECTION; DEVICE INFECTION; DISINFECTION; EVIDENCE BASED MEDICINE; HAND WASHING; HEALTH CARE; HEALTH CARE ASSOCIATED INFECTION; HEALTH CARE COST; HEALTH CARE DELIVERY; HEALTH CARE PERSONNEL; HEALTH CARE SYSTEM; HEALTH SERVICE; HOSPITAL INFECTION; HUMAN; HYGIENE; INFECTION PREVENTION; INSTRUMENT STERILIZATION; KLEBSIELLA PNEUMONIAE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MOUTH HYGIENE; NONHUMAN; PRESCRIPTION; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; REVIEW; STAPHYLOCOCCUS AUREUS; SURGICAL INFECTION; URINARY TRACT INFECTION; VENTILATOR ASSOCIATED PNEUMONIA;

ANTI-INFECTIVE AGENTS; CROSS INFECTION; HUMANS; INFECTION CONTROL; MORTALITY; RISK FACTORS; UNITED STATES;

EID: 84855947243     PISSN: 00664219     EISSN: 1545326X     Source Type: Book Series    
DOI: 10.1146/annurev-med-081210-144458     Document Type: Review

References (60)

1. Klevens RM, Edwards JR, Richards CL, et al. 2007. Estimating health care-associated infections and deaths in U. S. hospitals, 2002. Public Health Rep. 122:160-66
2. Morgan DJ, Lomotan LL, Agnes K, et al. 2010. Characteristics of healthcare-associated infections contributing to unexpected in-hospital deaths. Infect. Control Hosp. Epidemiol. 31:864-66
3. Scott R. 2009. The direct medical costs of healthcare-associated infections in U. S. hospitals and the benefits of prevention. Centers for Disease Control and Prevention. http://www. cdc. gov/ncidod/dhqp/pdf/Scott- CostPaper. pdf
4. Umscheid C, Mitchell M, Doshi J, et al. 2011. Estimating the proportion of healthcare-associated infections that are reasonably preventable and the related mortality and costs. Infect. Control Hosp. Epidemiol. 32:101-14
5. Institute of Medicine. 2000. To err is human: building a safer health system. Washington, DC: Natl. Acad. Press
6. Dowdle W. 1999. The principles of disease elimination and eradication. Morb. Mortal. Wkly. Rep. 48:23-27
7. Cardo D, Dennehy PH, Halverson P, et al. 2010. Moving toward elimination of healthcare-associated infections: a call to action. Infect. Control Hosp. Epidemiol. 31:1101-5
8. Berenholtz S, Pronovost P, Lipsett P, et al. 2004. Eliminating catheter-related bloodstream infections in the intensive care unit. Crit. Care Med. 32:2014-20 (Pubitemid 39372534)
9. Centers for Disease Control and Prevention. 2005. Reduction in central line-associated bloodstream infections among patients in intensive care units-Pennsylvania, April 2001-March 2005. Morb. Mortal. Wkly. Rep. 54:1013-16
10. Pronovost P, Needham D, Berenholtz S, et al. 2006. An intervention to decrease catheter-related bloodstream infections in the IC U. N. Engl. J. Med. 355:2725-32 (Pubitemid 46021509)
11. Centers for Disease Control and Prevention. 2011. Vital signs: central line-associated bloodstream infections-United States, 2001, 2008, and 2009. Morb. Mortal. Wkly. Rep. 60:243-48
12. Climo M, Diekema D, Warren D, et al. 2003. Prevalence of the use of central venous access devices within and outside of the intensive care unit: results of a survey among hospitals in the prevention epicenter program of the Centers for Disease Control and Prevention. Infect. Control Hosp. Epidemiol. 24:942-45 (Pubitemid 38029562)
13. Dudeck M, Horan T, Peterson K, et al. 2011. National Healthcare Safety Network (NHSN) report, data summary for 2009, device-associated module. Centers for Disease Control and Prevention. http://www. cdc. gov/nhsn/PDFs/dataStat/ 2010NHSNReport. pdf
14. Institute for Healthcare Improvement. 2010. Implement the IHI ventilator bundle. http://www. ihi. org/IHI/Topics/criticalcare/intensivecare/changes/ implementtheventilatorbundle. htm
15. Berenholtz SM, Pham JC, Thompson DA, et al. 2011. Collaborative cohort study of an intervention to reduce ventilator-associated pneumonia in the intensive care unit. Infect. Control Hosp. Epidemiol. 32:305-14
16. Gould C, Umscheid C, Agarwal R, et al., Healthcare Infection Control Practices Advisory Committee. 2009. Guideline for prevention of catheter-associated urinary tract infections 2009. Centers for Disease Control and Prevention. http://www. cdc. gov/hicpac/pdf/CAUTI/CAUTIguideline2009final. pdf
17. Munasinghe RL, Yazdani H, Siddique M, et al. 2001. Appropriateness of use of indwelling urinary catheters in patients admitted to the medical service. Infect. Control Hosp. Epidemiol. 22:647-49 (Pubitemid 33152109)
18. Saint S, Wiese J, Amory JK, et al. 2000. Are physicians aware of which of their patients have indwelling urinary catheters? Am. J. Med. 109:476-80
19. Meddings J, Rogers MA, Macy M, et al. 2010. Systematic review and meta-analysis: reminder systems to reduce catheter-associated urinary tract infections and urinary catheter use in hospitalized patients. Clin. Infect. Dis. 51:550-60
20. Saint S, Kowalski CP, Kaufman SR, et al. 2008. Preventing hospital-acquired urinary tract infection in the United States: a national study. Clin. Infect. Dis. 46:243-50 (Pubitemid 351269163)
21. Nicholas LH, Osborne NH, Birkmeyer JD, et al. 2010. Hospital process compliance and surgical outcomes in medicare beneficiaries. Arch. Surg. 145:999-1004
22. Hidron A, Edwards J, Patel J, et al. 2008. NHSN annual update: antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006-2007. Infect. Control Hosp. Epidemiol. 29:996-1011
23. Cosgrove SE. 2006. The relationship between antimicrobial resistance and patient outcomes: mortality, length of hospital stay, and health care costs. Clin. Infect. Dis. 42(Suppl. 2):S82-89 (Pubitemid 43054219)
24. Kallen A, Mu Y, Bulens S, et al. 2010. Health care-associated invasive MRSA infections, 2005-2008. JAMA 304:641-48
25. Paterson D, Doi Y. 2007. A step closer to extreme drug resistance (XDR) in gram-negative bacilli. Clin. Infect. Dis. 45:1179-81 (Pubitemid 47580316)
26. Falagas M, Karageorgopoulos D. 2008. Pandrug resistance (PDR), extensive drug resistance (XDR), and multidrug resistance (MDR) among gram-negative bacilli: need for international harmonization in terminology. Clin. Infect. Dis. 46:1121-22 (Pubitemid 351589881)
27. Paterson DL, Lipman J. 2007. Returning to the pre-antibiotic era in the critically ill: the XDR problem. Crit. Care Med. 35:1789-91 (Pubitemid 46985895)
28. Sinaii N, Research Committee of the Society of Healthcare Epidemiology of America. 2010. Charting the course for the future of science in healthcare epidemiology: results of a survey of the membership of the Society of Healthcare Epidemiology of America. Infect. Control Hosp. Epidemiol. 31:669-75
29. Kallen A, Hidron A, Patel J, et al. 2010. Multidrug resistance among gram-negative pathogens that caused healthcare-associated infections reported to the National Healthcare Safety Network, 2006-2008. Infect. Control Hosp. Epidemiol. 31:528-31
30. Patel G, Huprikar S, Factor SH, et al. 2008. Outcomes of carbapenem-resistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies. Infect. Control Hosp. Epidemiol. 29:1099-106
31. Centers for Disease Control and Prevention. 2010. Detection of Enterobacteriaceae isolates carrying metallo-beta-lactamase-United States, 2010. Morb. Mortal. Wkly. Rep. 59:750
32. Centers for Disease Control and Prevention. 2010. Update: detection of a Verona integron-encoded metallo-beta-lactamase in Klebsiella pneumoniae-United States, 2010. Morb. Mortal. Wkly. Rep. 59:1212
33. McDonald LC, Owings M, Jernigan DB. 2006. Clostridium difficile infection in patients discharged from US short-stay hospitals, 1996-2003. Emerg. Infect. Dis. 12:409-15
34. Ṕepin J, Valiquette L, Cossette B. 2005. Mortality attributable to nosocomial Clostridium difficile-associated disease during an epidemic caused by a hypervirulent strain in Quebec. Can. Med. Assoc. J. 173:1037-42
35. Muto CA, Pokrywka M, Shutt K, et al. 2005. A large outbreak of Clostridium difficile-associated disease with an unexpected proportion of deaths and colectomies at a teaching hospital following increased fluoroquinolone use. Infect. Control Hosp. Epidemiol. 26:273-80 (Pubitemid 40445086)
36. McDonald LC, Killgore GE, Thompson A, et al. 2005. An epidemic, toxin gene-variant strain of Clostridium difficile. N. Engl. J. Med. 353:2433-41 (Pubitemid 41770164)
37. Neuhauser MM, Weinstein RA, Rydman R, et al. 2003. Antibiotic resistance among gram-negative bacilli in US intensive care units: implications for fluoroquinolone use. JAMA 289:885-88 (Pubitemid 37430348)
38. Willemsen I, Bogaers-Hofman D, Winters M, et al. 2009. Correlation between antibiotic use and resistance in a hospital: temporary and ward-specific observations. Infection 37:432-37
39. Kern WV, Klose K, Jellen-Ritter AS, et al. 2005. Fluoroquinolone resistance of Escherichia coli at a cancer center: epidemiologic evolution and effects of discontinuing prophylactic fluoroquinolone use in neutropenic patients with leukemia. Eur. J. Clin. Microbiol. Infect. Dis. 24:111-18 (Pubitemid 40487379)
40. Hecker MT, Aron DC, Patel NP, et al. 2003. Unnecessary use of antimicrobials in hospitalized patients: current patterns of misuse with an emphasis on the antianaerobic spectrum of activity. Arch. Intern. Med. 163:972-78 (Pubitemid 36519743)
41. Camins BC, King MD, Wells JB, et al. 2009. Impact of an antimicrobial utilization program on antimicrobial use at a large teaching hospital: a randomized controlled trial. Infect. Control Hosp. Epidemiol. 30:931-38
42. Toth NR, Chambers RM, Davis SL. 2010. Implementation of a care bundle for antimicrobial stewardship. Am. J. Health Syst. Pharm. 67:746-49
43. Martin C, Ofotokun I, Rapp R, et al. 2005. Results of an antimicrobial control program at a university hospital. Am. J. Health Syst. Pharm. 62:732-38 (Pubitemid 40462843)
44. Patel D, Lawson W, Guglielmo BJ. 2008. Antimicrobial stewardship programs: interventions and associated outcomes. Exp. Rev. Anti Infect. Ther. 6:209-22
45. Davey P, Brown E, Fenelon L, et al. 2006. Systematic review of antimicrobial drug prescribing in hospitals. Emerg. Infect. Dis. 12:211-16
46. Carling P, Fung T, Killion A, et al. 2003. Favorable impact of a multidisciplinary antibiotic management program conducted during 7 years. Infect. Control Hosp. Epidemiol. 24:699-706 (Pubitemid 37221343)
47. Johannsson B, Beekmann SE, Srinivasan A, et al. 2011. Improving antimicrobial stewardship: the evolution of programmatic strategies and barriers. Infect. Control Hosp. Epidemiol. 32:367-74
48. Dubberke ER, Reske KA, Noble-Wang J, et al. 2007. Prevalence of Clostridium difficile environmental contamination and strain variability in multiple health care facilities. Am. J. Infect. Control 35:315-18 (Pubitemid 46907328)
49. Boyce J, Potter-Bynoe G, Chenevert C, et al. 1997. Environmental contamination due to methicillinresistant Staphylococcus aureus: possible infection control implications. Infect. Control Hosp. Epidemiol. 18:622-27 (Pubitemid 127470494)
50. Kramer A, Schwebke I, Kampf G. 2006. Howlong do nosocomial pathogens persist on inanimate surfaces? A systematic review. BMC Infect. Dis. 6:130
51. Huang S, Datta R, Platt R. 2006. Risk of acquiring antibiotic-resistant bacteria from prior room occupants. Arch. Intern. Med. 166:1945-51 (Pubitemid 44537174)
52. Datta R, Platt R, Yokoe D, et al. 2011. Environmental cleaning intervention and risk of acquiring multidrug-resistant organisms from prior room occupants. Arch. Intern. Med. 171:491-94
53. Zachary KC, Bayne PS, Morrison VJ, et al. 2001. Contamination of gowns, gloves, and stethoscopes with vancomycin-resistant enterococci. Infect. Control Hosp. Epidemiol. 22:560-64 (Pubitemid 33104883)
54. McFarland LV, Mulligan ME, Kwok RY, et al. 1989. Nosocomial acquisition of Clostridium difficile infection. N. Engl. J. Med. 320:204-10 (Pubitemid 19034145)
55. Bhalla A, Pultz N, Gries D, et al. 2004. Acquisition of nosocomial pathogens on hands after contact with environmental surfaces near hospitalized patients. Infect. Control Hosp. Epidemiol. 25:164-67 (Pubitemid 38252348)
56. Huskins W, Huckabee C, O'Grady N, et al. 2011. Intervention to reduce transmission of resistant bacteria in intensive care. N. Engl. J. Med. 364:1407-18
57. Centers for Disease Control and Prevention. 2008. Acute hepatitis C virus infections attributed to unsafe injection practices at an endoscopy clinic-Nevada, 2007. Morb. Mortal. Wkly. Rep. 57:513-17
58. Centers for Disease Control and Prevention. 2011. Notes from the field: deaths from acute hepatitis B virus infection associated with assisted blood glucose monitoring in an assisted-living facility-North Carolina, August-October, 2010. Morb. Mortal. Wkly. Rep. 60:182
59. Wendelboe AM, Baumbach J, Blossom DB, et al. 2008. Outbreak of cystoscopy related infections with Pseudomonas aeruginosa: New Mexico, 2007. J. Urol. 180:588-92; discussion 92
60. Centers for Disease Control and Prevention. 2006. Pseudomonas aeruginosa infections associated with transrectal ultrasound-guided prostate biopsies-Georgia, 2005. Morb. Mortal. Wkly. Rep. 55:776-77