Gene therapy restores missing cone-mediated vision in the CNGA3 -/- mouse model of achromatopsia

Advances in Experimental Medicine and Biology

Volumn 723, Issue , 2012, Pages 183-189

  Michalakis, Stylianos ^a   Mühlfriedel, Regine ^b   Tanimoto, Naoyuki ^b   Krishnamoorthy, Vidhyasankar ^c   Koch, Susanne ^a   Fischer, M Dominik ^b   Becirovic, Elvir ^a   Bai, Lin ^a   Huber, Gesine ^b   Beck, Susanne C ^b   Fahl, Edda ^b   Büning, Hildegard ^d   Schmidt, Jennifer ^a   Zong, Xiangang ^a   Gollisch, Tim ^c   Biel, Martin ^a   Seeliger, Mathias W ^b  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^c MAX PLANCK INSTITUTE OF NEUROBIOLOGY   (Germany)

^d UNIVERSITY OF COLOGNE   (Germany)

Author keywords

ACHM2; Achromatopsia; Adeno Associated Virus; CNGA3; Cone Phoroteceptor; Cyclic Nucleotide Gated Channel; Gene Replacement; Gene Therapy; rAAV; Rod Monochromacy

Indexed keywords

CATION CHANNEL; CYCLIC NUCLEOTIDE GATED CHANNEL A3; PARVOVIRUS VECTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CELL DEATH; COLOR BLINDNESS; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFECT; GENE EXPRESSION; GENE REPLACEMENT THERAPY; MOUSE; NONHUMAN; PHOTOPIC VISION; PRIORITY JOURNAL; RETINA BIPOLAR GANGLION CELL; RETINA CONE; RETINA GANGLION CELL; STIMULUS RESPONSE; VISUAL SYSTEM;

ANIMALS; COLOR VISION; COLOR VISION DEFECTS; CYCLIC NUCLEOTIDE-GATED CATION CHANNELS; DEPENDOVIRUS; ELECTRORETINOGRAPHY; GENE THERAPY; HEK293 CELLS; HUMANS; MICE; RECOMBINANT PROTEINS; RECOVERY OF FUNCTION; RETINAL CONE PHOTORECEPTOR CELLS; RETINAL ROD PHOTORECEPTOR CELLS;

ADENO-ASSOCIATED VIRUS; MUS;

EID: 84855926075     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4614-0631-0_25     Document Type: Conference Paper

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