메뉴 건너뛰기




Volumn 129, Issue 2, 2012, Pages 107-115

Use of anticoagulants in elderly patients

Author keywords

Anticoagulation; Apixaban; Dabigatran etexilate; Elderly patients; Rivaroxaban; Thromboembolism

Indexed keywords

ANTICOAGULANT AGENT; ANTIVITAMIN K; APIXABAN; DABIGATRAN ETEXILATE; FONDAPARINUX; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN; RIVAROXABAN; WARFARIN;

EID: 84855905401     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2011.09.013     Document Type: Review
Times cited : (54)

References (86)
  • 2
    • 78649344437 scopus 로고    scopus 로고
    • Venous thrombosis in the elderly: Incidence, risk factors and risk groups
    • M.J. Engbers, A. van Hylckama Vlieg, and F.R. Rosendaal Venous thrombosis in the elderly: incidence, risk factors and risk groups J Thromb Haemost 8 2010 2105 2112
    • (2010) J Thromb Haemost , vol.8 , pp. 2105-2112
    • Engbers, M.J.1    Van Hylckama Vlieg, A.2    Rosendaal, F.R.3
  • 8
    • 22244445841 scopus 로고    scopus 로고
    • Meta-analysis: The value of clinical assessment in the diagnosis of deep venous thrombosis
    • S. Goodacre, A.J. Sutton, and F.C. Sampson Meta-analysis: The value of clinical assessment in the diagnosis of deep venous thrombosis Ann Intern Med 143 2005 129 139
    • (2005) Ann Intern Med , vol.143 , pp. 129-139
    • Goodacre, S.1    Sutton, A.J.2    Sampson, F.C.3
  • 9
    • 34547865346 scopus 로고    scopus 로고
    • D-dimer concentration increases with age reducing the clinical value of the D-dimer assay in the elderly
    • DOI 10.1111/j.1445-5994.2007.01388.x
    • P.L. Harper, E. Theakston, J. Ahmed, and P. Ockelford D-dimer concentration increases with age reducing the clinical value of the D-dimer assay in the elderly Intern Med J 37 2007 607 613 (Pubitemid 47262895)
    • (2007) Internal Medicine Journal , vol.37 , Issue.9 , pp. 607-613
    • Harper, P.L.1    Theakston, E.2    Ahmed, J.3    Ockelford, P.4
  • 10
    • 0035832261 scopus 로고    scopus 로고
    • Prevalence of diagnosed atrial fibrillation in adults: National implications for rhythm management and stroke prevention: The anticoagulation and risk factors in atrial fibrillation (ATRIA) study
    • A.S. Go, E.M. Hylek, K.A. Phillips, Y. Chang, L.E. Henault, and J.V. Selby Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study JAMA 285 2001 2370 2375 (Pubitemid 32424106)
    • (2001) Journal of the American Medical Association , vol.285 , Issue.18 , pp. 2370-2375
    • Go, A.S.1    Hylek, E.M.2    Phillips, K.A.3    Chang, Y.C.4    Henault, L.E.5    Selby, J.V.6    Singer, D.E.7
  • 11
    • 45949095568 scopus 로고    scopus 로고
    • Antithrombotic therapy in atrial fibrillation: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition)
    • DOI 10.1378/chest.08-0678
    • D.E. Singer, G.W. Albers, J.E. Dalen, M.C. Fang, A.S. Go, and J.L. Halperin Antithrombotic therapy in atrial fibrillation: American College of Chest Physicians evidence-based clinical practice guidelines (8th Edition) Chest 133 2008 546S 592S (Pubitemid 351892972)
    • (2008) Chest , vol.133 , Issue.6 SUPPL. 6
    • Singer, D.E.1    Albers, G.W.2    Dalen, J.E.3    Fang, M.C.4    Go, A.S.5    Halperin, J.L.6    Lip, G.Y.H.7    Manning, W.J.8
  • 12
    • 0023625745 scopus 로고
    • Atrial fibrillation: A major contributor to stroke in the elderly. The Framingham study
    • DOI 10.1001/archinte.147.9.1561
    • P.A. Wolf, R.D. Abbott, and W.B. Kannel Atrial fibrillation: a major contributor to stroke in the elderly. The Framingham Study Arch Intern Med 147 1987 1561 1564 (Pubitemid 17138836)
    • (1987) Archives of Internal Medicine , vol.147 , Issue.9 , pp. 1561-1564
    • Wolf, P.A.1    Abbott, R.D.2    Kannel, W.B.3
  • 13
    • 0025779484 scopus 로고
    • Atrial fibrillation as an independent risk factor for stroke: The Framingham Study
    • P.A. Wolf, R.D. Abbott, and W.B. Kannel Atrial fibrillation as an independent risk factor for stroke: the Framingham Study Stroke 22 1991 983 988
    • (1991) Stroke , vol.22 , pp. 983-988
    • Wolf, P.A.1    Abbott, R.D.2    Kannel, W.B.3
  • 14
    • 46049090201 scopus 로고    scopus 로고
    • Prevention of venous thromboembolism: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition)
    • DOI 10.1378/chest.08-0656
    • W.H. Geerts, D. Bergqvist, G.F. Pineo, J.A. Heit, C.M. Samama, and M.R. Lassen Prevention of venous thromboembolism: American College of Chest Physicians evidence-based clinical practice guidelines (8th Edition) Chest 133 2008 381S 453S (Pubitemid 351894916)
    • (2008) Chest , vol.133 , Issue.6 SUPPL. 6
    • Geerts, W.H.1    Bergqvist, D.2    Pineo, G.F.3    Heit, J.A.4    Samama, C.M.5    Lassen, M.R.6    Colwell, C.W.7
  • 15
    • 45949100970 scopus 로고    scopus 로고
    • Antithrombotic therapy for venous thromboembolic disease: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition)
    • DOI 10.1378/chest.08-0658
    • C. Kearon, S.R. Kahn, G. Agnelli, S. Goldhaber, G.E. Raskob, and A.J. Comerota Antithrombotic therapy for venous thromboembolic disease: American College of Chest Physicians evidence-based clinical practice guidelines (8th Edition) Chest 133 2008 454S 545S (Pubitemid 351892971)
    • (2008) Chest , vol.133 , Issue.6 SUPPL. 6
    • Kearon, C.1    Kahn, S.R.2    Agnelli, G.3    Goldhaber, S.4    Raskob, G.E.5    Comerota, A.J.6
  • 16
    • 73449112003 scopus 로고    scopus 로고
    • Ageing and the glomerular filtration rate: Truths and consequences
    • R.J. Glassock, and C. Winearls Ageing and the glomerular filtration rate: truths and consequences Trans Am Clin Climatol Assoc 120 2009 419 428
    • (2009) Trans Am Clin Climatol Assoc , vol.120 , pp. 419-428
    • Glassock, R.J.1    Winearls, C.2
  • 18
    • 45949103309 scopus 로고    scopus 로고
    • Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    • DOI 10.1378/chest.08-0670
    • J. Ansell, J. Hirsh, E. Hylek, A. Jacobson, M. Crowther, and G. Palareti Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians evidence-based clinical practice guidelines (8th Edition) Chest 133 2008 160S 198S (Pubitemid 351892967)
    • (2008) Chest , vol.133 , Issue.6 SUPPL. 6
    • Ansell, J.1    Hirsh, J.2    Hylek, E.3    Jacobson, A.4    Crowther, M.5    Palareti, G.6
  • 19
    • 0036677922 scopus 로고    scopus 로고
    • The use of oral anticoagulants (warfarin) in older people. American Geriatrics Society guideline
    • ANON
    • Anon The use of oral anticoagulants (warfarin) in older people. American Geriatrics Society guideline J Am Geriatr Soc 50 2002 1439 1445
    • (2002) J Am Geriatr Soc , vol.50 , pp. 1439-1445
  • 20
    • 77957699729 scopus 로고    scopus 로고
    • Guidelines for the management of atrial fibrillation: The Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC)
    • A.J. Camm, P. Kirchhof, G.Y. Lip, U. Schotten, I. Savelieva, and S. Ernst Guidelines for the management of atrial fibrillation: The Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC) Eur Heart J 31 2010 2369 2429
    • (2010) Eur Heart J , vol.31 , pp. 2369-2429
    • Camm, A.J.1    Kirchhof, P.2    Lip, G.Y.3    Schotten, U.4    Savelieva, I.5    Ernst, S.6
  • 21
    • 85058205265 scopus 로고    scopus 로고
    • ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation
    • A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients with Atrial Fibrillation) developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society
    • V. Fuster, L.E. Rydén, D.S. Cannom, H.J. Crijns, A.B. Curtis, and K.A. Ellenbogen ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients with Atrial Fibrillation) developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society J Am Coll Cardiol 48 2006 e149 e246
    • (2006) J Am Coll Cardiol , vol.48
    • Fuster, V.1    Rydén, L.E.2    Cannom, D.S.3    Crijns, H.J.4    Curtis, A.B.5    Ellenbogen, K.A.6
  • 22
    • 4143085802 scopus 로고    scopus 로고
    • Randomized, placebo-controlled trial of dalteparin for the prevention of venous thromboembolism in acutely ill medical patients
    • DOI 10.1161/01.CIR.0000138928.83266.24
    • A. Leizorovicz, A.T. Cohen, A.G.G. Turpie, C.G. Olsson, P.T. Vaitkus, and S.Z. Goldhaber Randomized, placebo-controlled trial of dalteparin for the prevention of venous thromboembolism in acutely ill medical patients Circulation 110 2004 874 879 (Pubitemid 39096017)
    • (2004) Circulation , vol.110 , Issue.7 , pp. 874-879
    • Leizorovicz, A.1    Cohen, A.T.2    Turpie, A.G.G.3    Olsson, C.-G.4    Vaitkus, P.T.5    Goldhaber, S.Z.6
  • 23
    • 77955951754 scopus 로고    scopus 로고
    • Extended-duration venous thromboembolism prophylaxis in acutely ill medical patients with recently reduced mobility: A randomized trial
    • R.D. Hull, S.M. Schellong, V.F. Tapson, M. Monreal, M.M. Samama, and P. Nicol Extended-duration venous thromboembolism prophylaxis in acutely ill medical patients with recently reduced mobility: a randomized trial Ann Intern Med 153 2010 8 18
    • (2010) Ann Intern Med , vol.153 , pp. 8-18
    • Hull, R.D.1    Schellong, S.M.2    Tapson, V.F.3    Monreal, M.4    Samama, M.M.5    Nicol, P.6
  • 24
    • 0037383972 scopus 로고    scopus 로고
    • Randomized comparison of enoxaparin with unfractionated heparin for the prevention of venous thromboembolism in medical patients with heart failure or severe respiratory disease
    • DOI 10.1067/mhj.2003.189
    • F.X. Kleber, C. Witt, G. Vogel, K. Koppenhagen, U. Schomaker, and C.W. Flosbach Randomized comparison of enoxaparin with unfractionated heparin for the prevention of venous thromboembolism in medical patients with heart failure or severe respiratory disease Am Heart J 145 2003 614 621 (Pubitemid 36403489)
    • (2003) American Heart Journal , vol.145 , Issue.4 , pp. 614-621
    • Kleber, F.-X.1    Witt, C.2    Vogel, G.3    Koppenhagen, K.4    Schomaker, U.5    Flosbach, C.W.6
  • 25
    • 32844466981 scopus 로고    scopus 로고
    • Efficacy and safety of fondaparinux for the prevention of venous thromboembolism in older acute medical patients: Randomised placebo controlled trial
    • A.T. Cohen, B.L. Davidson, A.S. Gallus, M.R. Lassen, M.H. Prins, and W. Tomkowski Efficacy and safety of fondaparinux for the prevention of venous thromboembolism in older acute medical patients: randomised placebo controlled trial BMJ 332 2006 325 329
    • (2006) BMJ , vol.332 , pp. 325-329
    • Cohen, A.T.1    Davidson, B.L.2    Gallus, A.S.3    Lassen, M.R.4    Prins, M.H.5    Tomkowski, W.6
  • 26
    • 77955265201 scopus 로고    scopus 로고
    • Pulmonary embolism in patients over 90 years of age
    • M. Monreal, and L. López-Jiménez Pulmonary embolism in patients over 90 years of age Curr Opin Pulm Med 16 2010 432 436
    • (2010) Curr Opin Pulm Med , vol.16 , pp. 432-436
    • Monreal, M.1    López-Jiménez, L.2
  • 28
    • 0033633409 scopus 로고    scopus 로고
    • Update in unfractionated heparin, low-molecular-weight heparins, and heparinoids in the elderly (age ≥ 65 years)
    • S.A. Spinler, and C.M. Evans Update in unfractionated heparin, low-molecular-weight heparins, and heparinoids in the elderly (age ≥ 65 years) J Thromb Thrombolysis 9 2000 117
    • (2000) J Thromb Thrombolysis , vol.9 , pp. 117
    • Spinler, S.A.1    Evans, C.M.2
  • 29
    • 45949086068 scopus 로고    scopus 로고
    • Parenteral anticoagulants: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition)
    • DOI 10.1378/chest.08-0689
    • J. Hirsh, K.A. Bauer, M.B. Donati, M. Gould, M.M. Samama, and J.I. Weitz Parenteral anticoagulants: American College of Chest Physicians evidence-based clinical practice guidelines (8th Edition) Chest 133 2008 141S 159S (Pubitemid 351892966)
    • (2008) Chest , vol.133 , Issue.6 SUPPL. 6
    • Hirsh, J.1    Bauer, K.A.2    Donati, M.B.3    Gould, M.4    Samama, M.M.5    Weitz, J.I.6
  • 31
  • 32
    • 0033527355 scopus 로고    scopus 로고
    • Antithrombotic therapy to prevent stroke in patients with atrial fibrillation: A meta-analysis
    • R.G. Hart, O. Benavente, R. McBride, and L.A. Pearce Antithrombotic therapy to prevent stroke in patients with atrial fibrillation: a meta-analysis Ann Intern Med 131 1999 492 501 (Pubitemid 29482392)
    • (1999) Annals of Internal Medicine , vol.131 , Issue.7 , pp. 492-501
    • Hart, R.G.1    Benavente, O.2    McBride, R.3    Pearce, L.A.4
  • 34
    • 0027291892 scopus 로고
    • Bleeding complications in oral anticoagulant therapy: An analysis of risk factors
    • DOI 10.1001/archinte.153.13.1557
    • F.J. van der Meer, F.R. Rosendaal, J.P. Vandenbroucke, and E. Briët Bleeding complications in oral anticoagulant therapy. An analysis of risk factors Arch Intern Med 153 1993 1557 1562 (Pubitemid 23205854)
    • (1993) Archives of Internal Medicine , vol.153 , Issue.13 , pp. 1557-1562
    • Van Der Meer, F.J.M.1    Rosendaal, F.R.2    Vandenbroucke, J.P.3    Briet, E.4
  • 35
    • 0035080693 scopus 로고    scopus 로고
    • Oral anticoagulant therapy in patients with nonrheumatic atrial fibrillation and risk of bleeding: A multicenter inception cohort study
    • V. Pengo, C. Legnani, F. Noventa, and G. Palareti Oral anticoagulant therapy in patients with nonrheumatic atrial fibrillation and risk of bleeding. A Multicenter Inception Cohort Study Thromb Haemost 85 2001 418 422 (Pubitemid 32233011)
    • (2001) Thrombosis and Haemostasis , vol.85 , Issue.3 , pp. 418-422
    • Pengo, V.1    Legnani, C.2    Noventa, F.3    Palarenti, G.4
  • 36
    • 75749095224 scopus 로고    scopus 로고
    • Lower versus standard intensity oral anticoagulant therapy (OAT) in elderly warfarin-experienced patients with non-valvular atrial fibrillation
    • V. Pengo, U. Cucchini, G. Denas, B.L. Davidson, F. Marzot, and S.P. Jose Lower versus standard intensity oral anticoagulant therapy (OAT) in elderly warfarin-experienced patients with non-valvular atrial fibrillation Thromb Haemost 103 2010 442 449
    • (2010) Thromb Haemost , vol.103 , pp. 442-449
    • Pengo, V.1    Cucchini, U.2    Denas, G.3    Davidson, B.L.4    Marzot, F.5    Jose, S.P.6
  • 37
    • 19644400842 scopus 로고    scopus 로고
    • Advanced age, anticoagulation intensity, and risk for intracranial hemorrhage among patients taking warfarin for atrial fibrillation
    • M.C. Fang, Y. Chang, E.M. Hylek, J. Rosand, S.M. Greenberg, and A.S. Go Advanced age, anticoagulation intensity, and risk for intracranial hemorrhage among patients taking warfarin for atrial fibrillation Ann Intern Med 141 2004 745 752
    • (2004) Ann Intern Med , vol.141 , pp. 745-752
    • Fang, M.C.1    Chang, Y.2    Hylek, E.M.3    Rosand, J.4    Greenberg, S.M.5    Go, A.S.6
  • 38
    • 34249715284 scopus 로고    scopus 로고
    • Major hemorrhage and tolerability of warfarin in the first year of therapy among elderly patients with atrial fibrillation
    • DOI 10.1161/CIRCULATIONAHA.106.653048, PII 0000301720070529000005
    • E.M. Hylek, C. Evans-Molina, C. Shea, L.E. Henault, and S. Regan Major hemorrhage and tolerability of warfarin in the first year of therapy among elderly patients with atrial fibrillation Circulation 115 2007 2689 2696 (Pubitemid 46842784)
    • (2007) Circulation , vol.115 , Issue.21 , pp. 2689-2696
    • Hylek, E.M.1    Evans-Molina, C.2    Shea, C.3    Henault, L.E.4    Regan, S.5
  • 39
    • 78649508381 scopus 로고    scopus 로고
    • Factors affecting adherence to guidelines for antithrombotic therapy in elderly patients with atrial fibrillation admitted to internal medicine wards
    • M. Marcucci, A. Iorio, A. Nobili, M. Tettamanti, L. Pasina, and A. Marengoni Factors affecting adherence to guidelines for antithrombotic therapy in elderly patients with atrial fibrillation admitted to internal medicine wards Eur J Intern Med 21 2010 516 523
    • (2010) Eur J Intern Med , vol.21 , pp. 516-523
    • Marcucci, M.1    Iorio, A.2    Nobili, A.3    Tettamanti, M.4    Pasina, L.5    Marengoni, A.6
  • 40
    • 29144518504 scopus 로고    scopus 로고
    • Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939 - An oral, direct Factor Xa inhibitor - After multiple dosing in healthy male subjects
    • DOI 10.1007/s00228-005-0043-5
    • D. Kubitza, M. Becka, G. Wensing, B. Voith, and M. Zuehlsdorf Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939 - an oral, direct Factor Xa inhibitor - after multiple dosing in healthy male subjects Eur J Clin Pharmacol 61 2005 873 880 (Pubitemid 41803696)
    • (2005) European Journal of Clinical Pharmacology , vol.61 , Issue.12 , pp. 873-880
    • Kubitza, D.1    Becka, M.2    Wensing, G.3    Voith, B.4    Zuehlsdorf, M.5
  • 41
    • 55549139511 scopus 로고    scopus 로고
    • Dose-escalation study of the pharmacokinetics and pharmacodynamics of rivaroxaban in healthy elderly subjects
    • D. Kubitza, M. Becka, A. Roth, and W. Mueck Dose-escalation study of the pharmacokinetics and pharmacodynamics of rivaroxaban in healthy elderly subjects Curr Med Res Opin 24 2008 2757 2765
    • (2008) Curr Med Res Opin , vol.24 , pp. 2757-2765
    • Kubitza, D.1    Becka, M.2    Roth, A.3    Mueck, W.4
  • 42
    • 77952118055 scopus 로고    scopus 로고
    • Bayer Pharma Ag Available at
    • ® Summary of Product Characteristics Available at: http://www.medicines.org.uk/emc/document.aspx? documentId=21265 2011
    • (2011) ® Summary of Product Characteristics
  • 43
    • 34547110933 scopus 로고    scopus 로고
    • The effect of extreme age, and gender, on the pharmacology and tolerability of rivaroxaban - An oral, direct Factor Xa inhibitor
    • D. Kubitza, M. Becka, W. Mueck, and M. Zuehlsdorf The effect of extreme age, and gender, on the pharmacology and tolerability of rivaroxaban - an oral, direct Factor Xa inhibitor Blood (ASH Annual Meeting Abstracts) 108 2006 905
    • (2006) Blood (ASH Annual Meeting Abstracts) , vol.108 , pp. 905
    • Kubitza, D.1    Becka, M.2    Mueck, W.3    Zuehlsdorf, M.4
  • 44
    • 33947205635 scopus 로고    scopus 로고
    • Rivaroxaban (BAY 59-7939) - An oral, direct Factor Xa inhibitor - Has no clinically relevant interaction with naproxen
    • DOI 10.1111/j.1365-2125.2006.02776.x
    • D. Kubitza, M. Becka, W. Mueck, and M. Zuehlsdorf Rivaroxaban (BAY 59-7939) - an oral, direct Factor Xa inhibitor - has no clinically relevant interaction with naproxen Br J Clin Pharmacol 63 2007 469 476 (Pubitemid 46426627)
    • (2007) British Journal of Clinical Pharmacology , vol.63 , Issue.4 , pp. 469-476
    • Kubitza, D.1    Becka, M.2    Mueck, W.3    Zuehlsdorf, M.4
  • 45
    • 33747068794 scopus 로고    scopus 로고
    • Safety, tolerability, pharmacodynamics, and pharmacokinetics of rivaroxaban - An oral, direct factor Xa inhibitor - Are not affected by aspirin
    • DOI 10.1177/0091270006292127
    • D. Kubitza, M. Becka, W. Mueck, and M. Zuehlsdorf Safety, tolerability, pharmacodynamics, and pharmacokinetics of rivaroxaban - an oral, direct Factor Xa inhibitor - are not affected by aspirin J Clin Pharmacol 46 2006 981 990 (Pubitemid 44215062)
    • (2006) Journal of Clinical Pharmacology , vol.46 , Issue.9 , pp. 981-990
    • Kubitza, D.1    Becka, M.2    Mueck, W.3    Zuehlsdorf, M.4
  • 46
    • 64549143503 scopus 로고    scopus 로고
    • Co-administration of rivaroxaban - A novel, oral, direct Factor Xa inhibitor - And clopidogrel in healthy subjects
    • 189 (P1272)
    • D. Kubitza, M. Becka, W. Mueck, and M. Zuehlsdorf Co-administration of rivaroxaban - a novel, oral, direct Factor Xa inhibitor - and clopidogrel in healthy subjects Eur Heart J 28 Suppl 1 2007:189 (P1272)
    • (2007) Eur Heart J , vol.28 , Issue.SUPPL. 1
    • Kubitza, D.1    Becka, M.2    Mueck, W.3    Zuehlsdorf, M.4
  • 47
    • 33746784959 scopus 로고    scopus 로고
    • No interaction between the novel, oral direct Factor Xa inhibitor BAY 59-7939 and digoxin
    • (11)
    • D. Kubitza, M. Becka, M. Zuehlsdorf, and W. Mueck No interaction between the novel, oral direct Factor Xa inhibitor BAY 59-7939 and digoxin J Clin Pharmacol 46 2006 702 (11)
    • (2006) J Clin Pharmacol , vol.46 , pp. 702
    • Kubitza, D.1    Becka, M.2    Zuehlsdorf, M.3    Mueck, W.4
  • 48
    • 57449103733 scopus 로고    scopus 로고
    • No interaction between rivaroxaban - A novel, oral, direct factor Xa inhibitor - And atorvastatin
    • (P062)
    • D. Kubitza, W. Mueck, and M. Becka No interaction between rivaroxaban - a novel, oral, direct factor Xa inhibitor - and atorvastatin Pathophysiol Haemost Thromb 36 Suppl 1 2008 A40 (P062)
    • (2008) Pathophysiol Haemost Thromb , vol.36 , Issue.SUPPL. 1 , pp. 40
    • Kubitza, D.1    Mueck, W.2    Becka, M.3
  • 49
    • 42149159619 scopus 로고    scopus 로고
    • Apixaban, an oral direct Factor Xa inhibitor: Single-dose safety, pharmacokinetics and pharmacodynamics in healthy volunteers
    • (P-M-665)
    • C. Frost, Z. Yu, S. Nepal, R. Mosqueda-Garcia, and A. Shenker Apixaban, an oral direct Factor Xa inhibitor: single-dose safety, pharmacokinetics and pharmacodynamics in healthy volunteers J Thromb Haemost 5 Suppl 1 2007 (P-M-665)
    • (2007) J Thromb Haemost , vol.5 , Issue.SUPPL. 1
    • Frost, C.1    Yu, Z.2    Nepal, S.3    Mosqueda-Garcia, R.4    Shenker, A.5
  • 50
    • 80053972376 scopus 로고    scopus 로고
    • Effects of age and gender on the single-dose pharmacokinetics (PK) and pharmacodynamics (PD) of apixaban
    • (PP-MO-407)
    • C.E. Frost, S. Nepal, Y. Barrett, and F. LaCreta Effects of age and gender on the single-dose pharmacokinetics (PK) and pharmacodynamics (PD) of apixaban J Thromb Haemost 7 Suppl s2 2009 455 (PP-MO-407)
    • (2009) J Thromb Haemost , vol.7 , Issue.SUPPL. S2 , pp. 455
    • Frost, C.E.1    Nepal, S.2    Barrett, Y.3    Lacreta, F.4
  • 53
    • 58149401862 scopus 로고    scopus 로고
    • Apixaban, an oral direct Factor Xa inhibitor: Awaiting the verdict
    • J. Carreiro, and J. Ansell Apixaban, an oral direct Factor Xa inhibitor: awaiting the verdict Expert Opin Investig Drugs 17 2008 1937 1945
    • (2008) Expert Opin Investig Drugs , vol.17 , pp. 1937-1945
    • Carreiro, J.1    Ansell, J.2
  • 54
    • 34548031359 scopus 로고    scopus 로고
    • The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects
    • DOI 10.1111/j.1365-2125.2007.02899.x
    • J. Stangier, K. Rathgen, H. Stähle, D. Gansser, and W. Roth The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects Br J Clin Pharmacol 64 2007 292 303 (Pubitemid 47283865)
    • (2007) British Journal of Clinical Pharmacology , vol.64 , Issue.3 , pp. 292-303
    • Stangier, J.1    Rathgen, K.2    Stahle, H.3    Gansser, D.4    Roth, W.5
  • 55
    • 41949116970 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor dabigatran etexilate
    • DOI 10.2165/00003088-200847050-00001
    • J. Stangier Clinical pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor dabigatran etexilate Clin Pharmacokinet 47 2008 285 295 (Pubitemid 351508116)
    • (2008) Clinical Pharmacokinetics , vol.47 , Issue.5 , pp. 285-295
    • Stangier, J.1
  • 56
    • 37149005153 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of the direct oral thrombin inhibitor dabigatran in healthy elderly subjects
    • J. Stangier, H. Stähle, K. Rathgen, and R. Fuhr Pharmacokinetics and pharmacodynamics of the direct oral thrombin inhibitor dabigatran in healthy elderly subjects Clin Pharmacokinet 47 2008 47 59 (Pubitemid 350260888)
    • (2008) Clinical Pharmacokinetics , vol.47 , Issue.1 , pp. 47-59
    • Stangier, J.1    Stahle, H.2    Rathgen, K.3    Fuhr, R.4
  • 57
    • 77952167209 scopus 로고    scopus 로고
    • Pharmacology, pharmacokinetics, and pharmacodynamics of dabigatran etexilate, an oral direct thrombin inhibitor
    • J. Stangier, and A. Clemens Pharmacology, pharmacokinetics, and pharmacodynamics of dabigatran etexilate, an oral direct thrombin inhibitor Clin Appl Thromb Hemost 15 Suppl 1 2009 9S 16S
    • (2009) Clin Appl Thromb Hemost , vol.15 , Issue.SUPPL. 1
    • Stangier, J.1    Clemens, A.2
  • 58
    • 77953791376 scopus 로고    scopus 로고
    • No interaction of the oral direct thrombin inhibitor dabigatran etexilate and digoxin
    • (P-W-672)
    • J. Stangier, H. Stähle, K. Rathgen, K. Reseski, and T. Konicke No interaction of the oral direct thrombin inhibitor dabigatran etexilate and digoxin J Thromb Haemost 5 Suppl 2 2007 (P-W-672)
    • (2007) J Thromb Haemost , vol.5 , Issue.SUPPL. 2
    • Stangier, J.1    Stähle, H.2    Rathgen, K.3    Reseski, K.4    Konicke, T.5
  • 59
    • 77953787408 scopus 로고    scopus 로고
    • Coadministration of the oral direct thrombin inhibitor dabigatran etexilate and diclofenac has little impact on the pharmacokinetics of either drug
    • (P-T-677)
    • J. Stangier, H. Stähle, K. Rathgen, K. Reseski, and T. Kornicke Coadministration of the oral direct thrombin inhibitor dabigatran etexilate and diclofenac has little impact on the pharmacokinetics of either drug J Thromb Haemost 5 Suppl 2 2007 (P-T-677)
    • (2007) J Thromb Haemost , vol.5 , Issue.SUPPL. 2
    • Stangier, J.1    Stähle, H.2    Rathgen, K.3    Reseski, K.4    Kornicke, T.5
  • 60
    • 59349098538 scopus 로고    scopus 로고
    • Coadministration of dabigatran etexilate and atorvastatin: Assessment of potential impact on pharmacokinetics and pharmacodynamics
    • J. Stangier, K. Rathgen, H. Stähle, K. Reseski, T. Kornicke, and W. Roth Coadministration of dabigatran etexilate and atorvastatin: assessment of potential impact on pharmacokinetics and pharmacodynamics Am J Cardiovasc Drugs 9 2009 59 68
    • (2009) Am J Cardiovasc Drugs , vol.9 , pp. 59-68
    • Stangier, J.1    Rathgen, K.2    Stähle, H.3    Reseski, K.4    Kornicke, T.5    Roth, W.6
  • 62
    • 46049106502 scopus 로고    scopus 로고
    • Extended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: A double-blind, randomised controlled trial
    • A.K. Kakkar, B. Brenner, O.E. Dahl, B.I. Eriksson, P. Mouret, and J. Muntz Extended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: a double-blind, randomised controlled trial Lancet 372 2008 31 39
    • (2008) Lancet , vol.372 , pp. 31-39
    • Kakkar, A.K.1    Brenner, B.2    Dahl, O.E.3    Eriksson, B.I.4    Mouret, P.5    Muntz, J.6
  • 64
    • 65549169515 scopus 로고    scopus 로고
    • Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): A randomised trial
    • A.G.G. Turpie, M.R. Lassen, B.L. Davidson, K.A. Bauer, M. Gent, and L.M. Kwong Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): a randomised trial Lancet 373 2009 1673 1680
    • (2009) Lancet , vol.373 , pp. 1673-1680
    • Turpie, A.G.G.1    Lassen, M.R.2    Davidson, B.L.3    Bauer, K.A.4    Gent, M.5    Kwong, L.M.6
  • 65
    • 79952496003 scopus 로고    scopus 로고
    • Rivaroxaban for the prevention of venous thromboembolism after hip or knee arthroplasty. Pooled analysis of four studies
    • A.G.G. Turpie, M.R. Lassen, B.I. Eriksson, M. Gent, S.D. Berkowitz, and F. Misselwitz Rivaroxaban for the prevention of venous thromboembolism after hip or knee arthroplasty. Pooled analysis of four studies Thromb Haemost 105 2011 444 453
    • (2011) Thromb Haemost , vol.105 , pp. 444-453
    • Turpie, A.G.G.1    Lassen, M.R.2    Eriksson, B.I.3    Gent, M.4    Berkowitz, S.D.5    Misselwitz, F.6
  • 67
    • 77649113258 scopus 로고    scopus 로고
    • Apixaban versus enoxaparin for thromboprophylaxis after knee replacement (ADVANCE-2): A randomised double-blind trial
    • M.R. Lassen, G.E. Raskob, A. Gallus, G. Pineo, D. Chen, and P. Hornick Apixaban versus enoxaparin for thromboprophylaxis after knee replacement (ADVANCE-2): a randomised double-blind trial Lancet 375 2010 807 815
    • (2010) Lancet , vol.375 , pp. 807-815
    • Lassen, M.R.1    Raskob, G.E.2    Gallus, A.3    Pineo, G.4    Chen, D.5    Hornick, P.6
  • 69
    • 34548575058 scopus 로고    scopus 로고
    • Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: A randomised, double-blind, non-inferiority trial
    • DOI 10.1016/S0140-6736(07)61445-7, PII S0140673607614457
    • B.I. Eriksson, O.E. Dahl, N. Rosencher, A.A. Kurth, C.N. van Dijk, and S.P. Frostick Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: a randomised, double-blind, non-inferiority trial Lancet 370 2007 949 956 (Pubitemid 47393577)
    • (2007) Lancet , vol.370 , Issue.9591 , pp. 949-956
    • Eriksson, B.I.1    Dahl, O.E.2    Rosencher, N.3    Kurth, A.A.4    Van Dijk, C.N.5    Frostick, S.P.6    Prins, M.H.7    Hettiarachchi, R.8    Hantel, S.9    Schnee, J.10    Buller, H.R.11
  • 71
    • 57649123692 scopus 로고    scopus 로고
    • Oral thrombin inhibitor dabigatran etexilate vs North American enoxaparin regimen for prevention of venous thromboembolism after knee arthroplasty surgery
    • The Re-Mobilize Writing Committee
    • The RE-MOBILIZE Writing Committee Oral thrombin inhibitor dabigatran etexilate vs North American enoxaparin regimen for prevention of venous thromboembolism after knee arthroplasty surgery J Arthroplasty 24 2009 1 9
    • (2009) J Arthroplasty , vol.24 , pp. 1-9
  • 72
    • 80052341686 scopus 로고    scopus 로고
    • Extended-duration rivaroxaban thromboprophylaxis in acutely ill medical patients: MAGELLAN study protocol
    • A.T. Cohen, T.E. Spiro, H.R. Büller, L. Haskell, D. Hu, and R. Hull Extended-duration rivaroxaban thromboprophylaxis in acutely ill medical patients: MAGELLAN study protocol J Thromb Thrombolysis 31 2011 407 416
    • (2011) J Thromb Thrombolysis , vol.31 , pp. 407-416
    • Cohen, A.T.1    Spiro, T.E.2    Büller, H.R.3    Haskell, L.4    Hu, D.5    Hull, R.6
  • 73
    • 84859965096 scopus 로고    scopus 로고
    • Rivaroxaban compared with enoxaparin for the prevention of venous thromboembolism in acutely ill medical patients
    • Available at
    • A.T. Cohen, T.E. Spiro, H.R. Büller, L. Haskell, D. Hu, and R. Hull Rivaroxaban compared with enoxaparin for the prevention of venous thromboembolism in acutely ill medical patients American College of Cardiology Congress 60th Annual Scientific Session 2011 Available at: http://my. americanheart.org/idc/groups/ahamah-public/@wcm/@sop/@scon/documents/ downloadable/ucm-425442.pdf
    • (2011) American College of Cardiology Congress 60th Annual Scientific Session
    • Cohen, A.T.1    Spiro, T.E.2    Büller, H.R.3    Haskell, L.4    Hu, D.5    Hull, R.6
  • 74
    • 78650619315 scopus 로고    scopus 로고
    • Oral rivaroxaban for symptomatic venous thromboembolism
    • The Einstein Investigators
    • The EINSTEIN Investigators Oral rivaroxaban for symptomatic venous thromboembolism N Engl J Med 363 2010 2499 2510
    • (2010) N Engl J Med , vol.363 , pp. 2499-2510
  • 77
    • 77649249878 scopus 로고    scopus 로고
    • Apixaban for Reduction in Stroke and Other ThromboemboLic Events in Atrial Fibrillation (ARISTOTLE) trial: Design and rationale
    • R.D. Lopes, J.H. Alexander, S.M. Al-Khatib, J. Ansell, R. Diaz, and J.D. Easton Apixaban for Reduction In Stroke and Other ThromboemboLic Events in Atrial Fibrillation (ARISTOTLE) trial: design and rationale Am Heart J 159 2010 331 339
    • (2010) Am Heart J , vol.159 , pp. 331-339
    • Lopes, R.D.1    Alexander, J.H.2    Al-Khatib, S.M.3    Ansell, J.4    Diaz, R.5    Easton, J.D.6
  • 78
    • 77649254746 scopus 로고    scopus 로고
    • Rationale and design of AVERROES: Apixaban versus acetylsalicylic acid to prevent stroke in atrial fibrillation patients who have failed or are unsuitable for vitamin K antagonist treatment
    • J.W. Eikelboom, M. ODonnell, S. Yusuf, R. Diaz, G. Flaker, and R. Hart Rationale and design of AVERROES: Apixaban versus acetylsalicylic acid to prevent stroke in atrial fibrillation patients who have failed or are unsuitable for vitamin K antagonist treatment Am Heart J 159 2010 348 353
    • (2010) Am Heart J , vol.159 , pp. 348-353
    • Eikelboom, J.W.1    Odonnell, M.2    Yusuf, S.3    Diaz, R.4    Flaker, G.5    Hart, R.6
  • 79
    • 79551596213 scopus 로고    scopus 로고
    • AVERROES: Apixaban versus acetylsalicylic acid (ASA) to prevent strokes
    • Available at
    • S.J. Connolly, J. Eikelboom, G. Flaker, S. Kaatz, A. Avezum, and L. Piegas AVERROES: apixaban versus acetylsalicylic acid (ASA) to prevent strokes European Society of Cardiology congress 2010 Available at: http://www.escardio. org/congresses/esc-2010/congress-reports/Documents/Tuesday/AVERROES-discussant- slides-Connolly.pdf
    • (2010) European Society of Cardiology Congress
    • Connolly, S.J.1    Eikelboom, J.2    Flaker, G.3    Kaatz, S.4    Avezum, A.5    Piegas, L.6
  • 82
    • 70349306850 scopus 로고    scopus 로고
    • Can we rely on RE-LY?
    • B.F. Gage Can we rely on RE-LY? N Engl J Med 361 2009 1200 1202
    • (2009) N Engl J Med , vol.361 , pp. 1200-1202
    • Gage, B.F.1
  • 83
    • 79958126202 scopus 로고    scopus 로고
    • Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation: An analysis of the randomized evaluation of long-term anticoagulant therapy (RE-LY) trial
    • J.W. Eikelboom, L. Wallentin, S.J. Connolly, M. Ezekowitz, J.S. Healey, and J. Oldgren Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation: an analysis of the randomized evaluation of long-term anticoagulant therapy (RE-LY) trial Circulation 123 2011 2363 2372
    • (2011) Circulation , vol.123 , pp. 2363-2372
    • Eikelboom, J.W.1    Wallentin, L.2    Connolly, S.J.3    Ezekowitz, M.4    Healey, J.S.5    Oldgren, J.6
  • 84
    • 78649289929 scopus 로고    scopus 로고
    • Effects of renal impairment on the pharmacokinetics, pharmacodynamics and safety of rivaroxaban - An oral, direct Factor Xa inhibitor
    • D. Kubitza, M. Becka, W. Mueck, A. Halabi, H. Maatouk, and N. Klause Effects of renal impairment on the pharmacokinetics, pharmacodynamics and safety of rivaroxaban - an oral, direct Factor Xa inhibitor Br J Clin Pharmacol 70 2010 703 712
    • (2010) Br J Clin Pharmacol , vol.70 , pp. 703-712
    • Kubitza, D.1    Becka, M.2    Mueck, W.3    Halabi, A.4    Maatouk, H.5    Klause, N.6
  • 86
    • 40749131754 scopus 로고    scopus 로고
    • New anticoagulants for treatment of venous thromboembolism
    • P.L. Gross, and J.I. Weitz New anticoagulants for treatment of venous thromboembolism Arterioscler Thromb Vasc Biol 28 2008 380 386
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 380-386
    • Gross, P.L.1    Weitz, J.I.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.