Anthrax lethal and edema toxins fail to directly impair human platelet function

Journal of Infectious Diseases

Volumn 205, Issue 3, 2012, Pages 453-457

  Chauncey, Kassidy M ^a   Szarowicz, Sarah E ^a   Sidhu, Gurjit S ^a   During, Russell L ^a   Southwick, Frederick S ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRAX TOXIN; CYCLIC AMP; EDEMA TOXIN; FORSKOLIN; HEAT SHOCK PROTEIN 27; ISOBUTYLMETHYLXANTHINE; LETHAL TOXIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; PADGEM PROTEIN; THROMBIN RECEPTOR ACTIVATING PEPTIDE; TUMOR ENDOTHELIAL MARKER 8; TUMOR MARKER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTHRAX; ARTICLE; BLEEDING; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; HELA CELL; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; THROMBOCYTE ACTIVATION; THROMBOCYTE FUNCTION; TOXICOKINETICS; TOXIN ANALYSIS; WESTERN BLOTTING;

ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL TOXINS; BLOOD PLATELETS; CYCLIC AMP; GENE EXPRESSION PROFILING; HUMAN EXPERIMENTATION; HUMANS; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-6; MEMBRANE PROTEINS; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; NEOPLASM PROTEINS; PROTEOLYSIS; RECEPTORS, CELL SURFACE;

EID: 84855886733     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jir763     Document Type: Article

References (15)

1. Borio L, Frank D, Mani V, et al. Death due to bioterrorism-related inhalational anthrax: report of 2 patients. JAMA 2001;286:2554-9. (Pubitemid 33096806)
2. Collier RJ, Young JA. Anthrax toxin. Annu Rev Cell Dev Biol 2003;19:45-70. (Pubitemid 37487342)
3. Duesbery NS, Webb CP, Leppla SH, et al. Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor. Science 1998;280:734-7. (Pubitemid 28243347)
4. Leppla SH. Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells. Proc Natl Acad Sci U S A 1982;79:3162-6. (Pubitemid 12008374)
5. Culley NC, Pinson DM, Chakrabarty A, Mayo MS, Levine SM. Pathophysiological manifestations in mice exposed to anthrax lethal toxin. Infect Immun 2005;73:7006-10. (Pubitemid 41368870)
6. Twenhafel NA, Leffel E, Pitt ML. Pathology of inhalational anthrax infection in the African green monkey. Vet Pathol 2007;44:716-21. (Pubitemid 47451244)
7. Guarner J, Jernigan JA, Shieh WJ, et al. Pathology and pathogenesis of bioterrorism-related inhalational anthrax. Am J Pathol 2003;163:701-9. (Pubitemid 36909431)
8. Alam S, Gupta M, Bhatnagar R. Inhibition of platelet aggregation by anthrax edema toxin. Biochem Biophys Res Commun 2006;339:107-14. (Pubitemid 41697521)
9. Kau JH, Sun DS, Tsai WJ, et al. Antiplatelet activities of anthrax lethal toxin are associated with suppressed p42/44 and p38 mitogenactivated protein kinase pathways in the platelets. J Infect Dis 2005;192:1465-74.
10. Quinn CP, Shone CC, Turnbull PC, Melling J. Purification of anthraxtoxin components by high-performance anion-exchange, gel-filtration and hydrophobic-interaction chromatography. Biochem J 1988;252:753-8.
11. Shebuski RJ, Kilgore KS. Role of inflammatory mediators in thrombogenesis. J Pharmacol Exp Ther 2002;300:729-35. (Pubitemid 34164973)
12. Wei W, Lu Q, Chaudry GJ, Leppla SH, Cohen SN. The LDL receptorrelated protein LRP6 mediates internalization and lethality of anthrax toxin. Cell 2006;124:1141-54.
13. During RL, Gibson BG, Li W, et al. Anthrax lethal toxin paralyzes actinbased motility by blocking Hsp27 phosphorylation. EMBO J 2007;26:2240-50. (Pubitemid 46685867)
14. Szarowicz SE, During RL, Li W, Quinn CP, Tang WJ, Southwick FS. Bacillus anthracis edema toxin impairs neutrophil actin-based motility. Infect Immun 2009;77:2455-64.
15. During RL, Li W, Hao B, et al. Anthrax lethal toxin paralyzes neutrophil actin-based motility. J Infect Dis 2005;192:837-45. (Pubitemid 41193081)