Summary of evidence on immediate statins therapy following aneurysmal subarachnoid hemorrhage

Neurocritical Care

Volumn 15, Issue 2, 2011, Pages 298-301

  Tseng, M Y ^a  

^a QUEEN S MEDICAL CENTRE   (United Kingdom)

Author keywords

Delayed ischemic deficits; Function; Pravastatin; Simvastatin; Vasospasm

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MAGNESIUM; PLACEBO; PRAVASTATIN; SIMVASTATIN;

BRAIN ISCHEMIA; BRAIN VASOSPASM; DELAYED ISCHEMIC DEFICIT; DOPPLER ECHOGRAPHY; DRUG EFFECT; DRUG SAFETY; DRUG WITHDRAWAL; EVIDENCE BASED MEDICINE; HUMAN; LIVER FUNCTION; META ANALYSIS (TOPIC); MORTALITY; MYALGIA; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RETROSPECTIVE STUDY; REVIEW; SIDE EFFECT; SUBARACHNOID HEMORRHAGE; SYSTEMATIC REVIEW; ACUTE DISEASE; INTENSIVE CARE; METHODOLOGY;

ACUTE DISEASE; BRAIN ISCHEMIA; CRITICAL CARE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; SUBARACHNOID HEMORRHAGE; VASOSPASM, INTRACRANIAL;

EID: 84855865352     PISSN: 15416933     EISSN: 15560961     Source Type: Journal    
DOI: 10.1007/s12028-011-9596-6     Document Type: Review

References (15)

1. Bederson JB, Connolly ES Jr, Batjer HH, et al. Guidelines for the management of aneurysmal subarachnoid hemorrhage: A statement for healthcare professionals from a special writing group of the Stroke Council, American Heart Association. Stroke. 2009;40:994-1025.
2. Sabri M, Macdonald RL. Statins: A potential therapeutic addition to treatment for aneurysmal subarachnoid hemorrhage? World Neurosurg. 2010;73:646-53.
3. Tseng M, Czosnyka M, Richards H, Pickard JD, Kirkpatrick PJ. Effects of acute treatment with pravastatin on cerebral vasospasm, autoregulation, and delayed ischemic deficits after aneurysmal subarachnoid hemorrhage: A phase II randomized placebo-controlled trial. Stroke. 2005;36:1627-32. (Pubitemid 41098752)
4. Lynch JR, Wang H, McGirt MJ, et al. Simvastatin reduces vasospasm after aneurysmal subarachnoid hemorrhage. Stroke. 2005;36:2024-6.
5. Vergouwen MD, de Haan RJ, Vermeulen M, Roos YB. Effect of statin treatment on vasospasm, delayed cerebral ischemia, and functional outcome in patients with aneurysmal subarachnoid hemorrhage: A systematic review and meta-analysis update. Stroke. 2010;41:e47-52.
6. Kramer AH, Fletcher JJ. Statins in the management of patients with aneurysmal subarachnoid hemorrhage: A systemic review and meta-analysis. Neurocrit Care. 2010;12:285-96.
7. Atkins D, Best D, Briss PA, et al. Grading quality of evidence and strength of recommendations. BMJ. 2004;328:1490.
8. Chou SH, Smith EE, Badjatia N, et al. A randomized, doubleblind, placebo-controlled pilot study of simvastatin in aneurysmal subarachnoid hemorrhage. Stroke. 2008;39:2891-3.
9. Vergouwen M, Meijers J, Geskus RB, et al. Biological effects of simvastatin in patients with aneurysmal subarachnoid hemorrhage: A double-blind, placebo-controlled randomized trial. J Cereb Blood Flow Metab. 2009;29:1444-53.
10. Jaschinski U, Scherer K, Lichtwarck M, Forst H. Impact of treatment with pravastatin on delayed ischemic disease and mortality after aneurysmal subarachnoid hemorrhage. Critical Care. 2008;12(Suppl 2):P112.
11. Macedo S, Belio Y, Siqueria C, Siqueria S, Brito L. Effects of simvastatin in prevention of vasospasm in nontraumatic subarachnoid hemorrhage: Preliminary data. Critical Care. 2009; 13(Suppl 1):P103.
12. Kramer AH, Gurka MJ, Nathan B, Dumont AS, Kassell NF, Bleck TP. Statin use was not associated with less vasospasm or improved outcome after subarachnoid hemorrhage. Neurosurgery. 2008;62:422-7. (Pubitemid 351489260)
13. McGirt MJ, Garces Ambrossi GL, Huang J, Tamargo RJ. Simvastatin for the prevention of symptomatic cerebral vasospasm following aneurysmal subarachnoid hemorrhage: A single-institution prospective cohort study. J Neurosurg. 2009;110:968-74.
14. Kern M, Lam MM, Knuckey NW, Lind CR. Statins may not protect against vasospasm in subarachnoid hemorrhage. J Clin Neurosci. 2009;16:527-30.
15. Kerz T, Victor A, Beyer C, Trapp I, Heid F, Reisch R. A case control study of statin and magnesium administration in patients after aneurysmal subarachnoid hemorrhage: Incidence of delayed cerebral ischemia and mortality. Neurol Res. 2008;30:893-7.