Elevated plasma factor VIII levels in patients with venous thrombosis - Constitutional risk factor or secondary epiphenomenon?

Thrombosis Research

Volumn 129, Issue 2, 2012, Pages 105-106

  Ryan, Kevin ^a   O'Donnell, James S ^a,b  

^a ST JAMES S HOSPITAL   (Ireland)

^b TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE PHASE PROTEIN; ANTIVITAMIN K; BLOOD CLOTTING FACTOR 8; C REACTIVE PROTEIN; FIBRINOGEN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; VON WILLEBRAND FACTOR;

ANTICOAGULANT THERAPY; EDITORIAL; GENE LOCUS; GENETIC POLYMORPHISM; GENETIC RISK; HUMAN; NONHUMAN; PHENOMENOLOGY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; RISK ASSESSMENT; RISK FACTOR; SEQUENCE ANALYSIS; VENOUS THROMBOEMBOLISM;

BIOLOGICAL MARKERS; FACTOR VIII; HUMANS; PREVALENCE; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT; RISK FACTORS; SENSITIVITY AND SPECIFICITY; VENOUS THROMBOSIS;

EID: 84855864634     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2011.10.002     Document Type: Editorial

References (14)

1. T. Koster, A.D. Blann, E. Briet, E. Briët, J.P. Vandenbroucke, and F.R. Rosendaal Role of clotting factor VIII in effect of von Willebrand factor on occurrence of deep-vein thrombosis Lancet 345 1995 152 155
2. J. ODonnell, E.G. Tuddenham, R. Manning, G. Kemball-Cook, D. Johnson, and M. Laffan High prevalence of elevated factor VIII levels in patients referred for thrombophilia screening: role of increased synthesis and relationship to the acute phase reaction Thromb Haemost 77 1997 825 828 (Pubitemid 27239098)
3. R.A. Kraaijenhagen, P.S. int Anker, M.M. Koopman, P.H. Reitsma, M.H. Prins, A. van den Ende, and H.R. Büller High plasma concentration of factor VIIIc is a major risk factor for venous thromboembolism Thromb Haemost 83 2000 5 9 (Pubitemid 30045467)
4. P.A. Kyrle, E. Minar, M. Hirschl, C. Bialonczyk, M. Stain, B. Schneider, A. Weltermann, W. Speiser, K. Lechner, and S. Eichinger High plasma levels of factor VIII and the risk of recurrent venous thromboembolism N Engl J Med 343 2000 457 462 (Pubitemid 30646484)
5. P.W. Kamphuisen, J.J. Houwing-Duistermaat, H.C. van Houwelingen, J.C. Eikenboom, R.M. Bertina, and F.R. Rosendaal Familial clustering of factor VIII and von Willebrand factor levels Thromb Haemost 79 1998 323 327 (Pubitemid 28065878)
6. I. Bank, E.J. Libourel, S. Middeldorp, K. Hamulyák, E.C. van Pampus, M.M. Koopman, M.H. Prins, J. van der Meer, and H.R. Büller Elevated levels of FVIII:C within families are associated with an increased risk for venous and arterial thrombosis J Thromb Haemost 3 2005 79 84 (Pubitemid 41647118)
7. E.P.G. Mansvelt, M. Laffan, J.H. McVey, and E.G.D. Tuddenham Analysis of the F8 gene in individuals with high plasma Factor VIII:C levels and associated venous thrombosis Thromb Haemost 80 1998 561 565 (Pubitemid 28479338)
8. J. ODonnell, A.D. Mumford, R.A. Manning, and M.A. Laffan Elevation of FVIII: C in venous thromboembolism is persistent and independent of the acute phase response Thromb Haemost 83 2000 10 13 (Pubitemid 30045468)
9. D.J. Bowen, R.M. MacLean, S. Pellard, and P.W. Collins High concentrations of coagulation factor VIII and thrombosis: Is the factor VIII-binding domain of von Willebrand factor implicated? Br J Haematol 113 2001 655 657 (Pubitemid 32524386)
10. N. Bovenschen, J. Herz, J.M. Grimbergen, P.J. Lenting, L.M. Havekes, K. Mertens, and B.J. van Vlijmen Elevated plasma factor VIII in a mouse model of low-density lipoprotein receptor-related protein deficiency Blood 101 2003 3933 3939 (Pubitemid 36857869)
11. N. Cunningham, M.A. Laffan, R.A. Manning, and J.S. ODonnell Low-density lipoprotein receptor-related protein polymorphisms in patients with elevated factor VIII coagulant activity and venous thrombosis Blood Coagul Fibrinolysis 16 2005 465 468 (Pubitemid 41794939)
12. R. Vormittag, P. Bencur, C. Ay, T. Tengler, T. Vukovich, P. Quehenberger, C. Mannhalter, and I. Pabinger Low-density lipoprotein receptor-related protein 1 polymorphism 663 C > T affects clotting factor VIII activity and increases the risk of venous thromboembolism J Thromb Haemost 5 2007 497 502 (Pubitemid 46680681)
13. P.W. Kamphuisen, J.C. Eikenboom, H.L. Vos, R. Pablo, A. Sturk, R.M. Bertina, and F.R. Rosendaal Increased levels of factor VIII and fibrinogen in patients with venous thrombosis are not caused by acute phase reactions Thromb Haemost 81 1999 680 683 (Pubitemid 29216549)
14. V.Y. Tichelaar, A.B. Mulder, H.C. Kluin-Nelemans, and K. Meijer The acute phase reaction explains only a part of initially elevated factor VIII levels: a prospective cohort study in patients with venous thrombosis Thromb Res 2011.