Roles of αvβ5, FAK and MerTK in oxidative stress inhibition of RPE cell phagocytosis

Experimental Eye Research

Volumn 94, Issue 1, 2012, Pages 63-70

  Qin, Suofu ^a   Rodrigues, Gerard A ^a  

^a ALLERGAN INC   (United States)

Author keywords

V 5; Cathepsin D; FAK; MerTK; Oxidative stress; Phagocytosis

Indexed keywords

ALPHAVBETA5 INTEGRIN; CATHEPSIN D; FOCAL ADHESION KINASE; MER TYROSINE KINASE; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ARTICLE; CELL ADHESION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PHAGOCYTOSIS; PHOTORECEPTOR OUTER SEGMENT; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN TRANSPORT;

CATHEPSIN D; CELL ADHESION; CELL LINE; CELL SURVIVAL; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; FOCAL ADHESION KINASE 1; HUMANS; HYDROGEN PEROXIDE; IMMUNOBLOTTING; OXIDATIVE STRESS; PHAGOCYTOSIS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, VITRONECTIN; RETINAL PHOTORECEPTOR CELL OUTER SEGMENT; RETINAL PIGMENT EPITHELIUM;

EID: 84855847446     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2011.11.007     Document Type: Article

References (32)

1. Cai J., Nelson K.C., Wu M., Sternberg P., Jones D.P. Oxidative damage and protection of the RPE. Prog. Retin. Eye Res. 2000, 19:205-221.
2. Chaitin M.H., Hall M.O. Defective ingestion of rod outer segments by cultured dystrophic rat pigment epithelial cells. Invest. Ophthalmol. Vis. Sci. 1983, 24:812-820.
3. Cougoule C., Wiedemann A., Lim J., Caron E. Phagocytosis, an alternative model system for the study of cell adhesion. Semin. Cell Dev. Biol. 2004, 15:679-689.
4. D'Cruz P.M., Yasumura D., Weir J., Matthes M.T., Abderrahim H., Lavail M.M., Vollrath D. Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat. Hum. Mol. Genet. 2000, 9:645-651.
5. Deguchi J., Yamamoto A., Yoshimori T., Sugasawa K., Moriyama Y., Futai M., Suzuki T., Kato K., Uyama M., Tashiro Y. Acidification of phagosomes and degradation of rod outer segments in rat retinal pigment epithelium. Invest. Ophthalmol. Vis. Sci. 1994, 35:568-579.
6. Duncan J.L., Lavail M.M., Yasumura D., Matthes M.T., Yang H., Trautmann N., Chappelow A.V., Feng W., Earp H.S., Matsushima G.K., Vollrath D. An RCS-like retinal dystrophy phenotype in mer knockout mice. Invest. Ophthalmol. Vis. Sci. 2003, 44:826-838.
7. Evans J.R. Risk factors for age-related macular degeneration. Prog. Retin. Eye Res. 2001, 20:227-253.
8. Feng W., Yasumura D., Matthes M.T., Lavail M.M., Vollrath D. Mertk triggers uptake of photoreceptor outer segments during phagocytosis by cultured retinal pigment epithelial cells. J.Biol. Chem. 2002, 277:17016-17022.
9. Finnemann S.C. Focal adhesion kinase signaling promotes phagocytosis of integrin-bound photoreceptors. EMBO J. 2003, 22:4143-4154.
10. Finnemann S.C., Bonilha V.L., Marmorstein A.D., Rodriguez-Boulan E. Phagocytosis of rod outer segments by retinal pigment epithelial cells requires alpha(v)beta5 integrin for binding but not for internalization. Proc. Natl. Acad. Sci. U.S.A. 1997, 94:12932-12937.
11. Finnemann S.C., Silverstein R.L. Differential roles of CD36 and alphavbeta5 integrin in photoreceptor phagocytosis by the retinal pigment epithelium. J.Exp. Med. 2001, 194:1289-1298.
12. Honda S., Hjelmeland L.M., Handa J.T. The use of hyperoxia to induce chronic mild oxidative stress in RPE cells invitro. Mol. Vis. 2001, 7:63-70.
13. Hoppe G., Marmorstein A.D., Pennock E.A., Hoff H.F. Oxidized low density lipoprotein-induced inhibition of processing of photoreceptor outer segments by RPE. Invest. Ophthalmol. Vis. Sci. 2001, 42:2714-2720.
14. Hoppe G., O'neil J., Hoff H.F., Sears J. Products of lipid peroxidation induce missorting of the principal lysosomal protease in retinal pigment epithelium. Biochim. Biophys. Acta 2004, 1689:33-41.
15. Kaemmerer E., Schutt F., Krohne T.U., Holz F.G., Kopitz J. Effects of lipid peroxidation-related protein modifications on RPE lysosomal functions and POS phagocytosis. Invest. Ophthalmol. Vis. Sci. 2007, 48:1342-1347.
16. Ling L., Templeton D., Kung H.J. Identification of the major autophosphorylation sites of Nyk/Mer, an NCAM-related receptor tyrosine kinase. J.Biol. Chem. 1996, 271:18355-18362.
17. McBee J.K., Palczewski K., Baehr W., Pepperberg D.R. Confronting complexity: the interlink of phototransduction and retinoid metabolism in the vertebrate retina. Prog. Retin. Eye Res. 2001, 20:469-529.
18. McLaren M.J., Inana G., Li C.Y. Double fluorescent vital assay of phagocytosis by cultured retinal pigment epithelial cells. Invest. Ophthalmol. Vis. Sci. 1993, 34:317-326.
19. Miceli M.V., Liles M.R., Newsome D.A. Evaluation of oxidative processes in human pigment epithelial cells associated with retinal outer segment phagocytosis. Exp. Cell Res. 1994, 214:242-249.
20. Molday R.S., Hicks D., Molday L. Peripherin. A rim-specific membrane protein of rod outer segment discs. Invest. Ophthalmol. Vis. Sci. 1987, 28:50-61.
21. Nandrot E.F., Anand M., Almeida D., Atabai K., Sheppard D., Finnemann S.C. Essential role for MFG-E8 as ligand for alphavbeta5 integrin in diurnal retinal phagocytosis. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:12005-12010.
22. Nandrot E.F., Kim Y., Brodie S.E., Huang X., Sheppard D., Finnemann S.C. Loss of synchronized retinal phagocytosis and age-related blindness in mice lacking alphavbeta5 integrin. J.Exp. Med. 2004, 200:1539-1545.
23. Nguyen-Legros J., Hicks D. Renewal of photoreceptor outer segments and their phagocytosis by the retinal pigment epithelium. Int. Rev. Cytol. 2000, 196:245-313.
24. Olchawa M., Szewczyk G., Zareba M., Pilat A., Bzowska M., Mikolajczyk T., Sarna T. Sub-lethal photodynamic damage to ARPE-19 cells transiently inhibits their phagocytic activity. Photochem. Photobiol. 2010, 86:772-780.
25. Qin S. Oxidative damage of retinal pigment epithelial cells and age-related macular degeneration. Drug Dev. Res. 2007, 68:213-225.
26. Qin S., Mclaughlin A.P., De Vries G.W. Protection of RPE cells from oxidative injury by 15-deoxy-delta12,14-prostaglandin J2 by augmenting GSH and activating MAPK. Invest. Ophthalmol. Vis. Sci. 2006, 47:5098-5105.
27. Qin S., Rodrigues G.A. Roles of reactive oxygen species in the etiology of age-related macular degeneration. Handbook of Free Radicals: Formation, Types and Effects 2010, 167-196. Nova Science Publisher. D. Kozyrev, V. Slutsky (Eds.).
28. Schaller M.D., Hildebrand J.D., Shannon J.D., Fox J.W., Vines R.R., Parsons J.T. Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src. Mol. Cell Biol. 1994, 14:1680-1688.
29. Schvartz I., Seger D., Shaltiel S. Vitronectin. Int. J. Biochem. Cell Biol. 1999, 31:539-544.
30. Sheu S.J., Liu N.C., Chen J.L. Resveratrol protects human retinal pigment epithelial cells from acrolein-induced damage. J.Ocul. Pharmacol. Ther. 2010, 26:231-236.
31. Strauss O., Steinhausen K., Wienrich M., Wiederholt M. Activation of a Cl-conductance by protein kinase-dependent phosphorylation in cultured rat retinal pigment epithelial cells. Exp. Eye Res. 1998, 66:35-42.
32. Sun M., Finnemann S.C., Febbraio M., Shan L., Annangudi S.P., Podrez E.A., Hoppe G., Darrow R., Organisciak D.T., Salomon R.G., Silverstein R.L., Hazen S.L. Light-induced oxidation of photoreceptor outer segment phospholipids generates ligands for CD36-mediated phagocytosis by retinal pigment epithelium: a potential mechanism for modulating outer segment phagocytosis under oxidant stress conditions. J.Biol. Chem. 2006, 281:4222-4230.