Sotrastaurin, a new selective protein kinase C inhibitor, on the way

Transplantation

Volumn 93, Issue 2, 2012, Pages 146-147

  Yamashita, Kenichiro ^a   Todo, Satoru ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN INHIBITOR; CYCLOSPORIN A; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN KINASE C DELTA; PROTEIN KINASE C EPSILON; PROTEIN KINASE C ETA; PROTEIN KINASE C GAMMA; PROTEIN KINASE C THETA; SOTRASTAURIN; TACROLIMUS;

ACUTE GRAFT REJECTION; APOPTOSIS; AUTOPHAGY; CELL ACTIVATION; CELL DIFFERENTIATION; CELL PROLIFERATION; DRUG EFFICACY; DRUG METABOLISM; DRUG POTENTIATION; DRUG SAFETY; GLOMERULUS FILTRATION RATE; GRAFT SURVIVAL; HUMAN; IMMUNOCOMPETENT CELL; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY TRANSPLANTATION; NONHUMAN; NOTE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; CYCLOSPORINE; GRAFT SURVIVAL; HUMANS; KIDNEY TRANSPLANTATION; PYRROLES; QUINAZOLINES;

EID: 84855837715     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e31823d4b1f     Document Type: Note

References (5)

1. Tan SL, Parker PJ. Emerging and diverse roles of protein kinase C in immune cell signalling. Biochem J 2003; 376 (Pt 3): 545.
2. Wagner J, von Matt P, Sedrani R, et al. Discovery of 3-(1H-indol-3-yl)-4- [2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes. J Med Chem 2009; 52: 6193.
3. Bigaud M, Wieczorek G, Beerli C, et al. Sotrastaurin (AEB071) alone and in combination with cyclosporine A prolongs survival times of non-human primate recipients of life-supporting kidney allografts. Transplantation 2012; 93: 156.
4. Friman S, Arns W, Nashan B, et al. Sotrastaurin, a novel small molecule inhibiting protein-kinase C: Randomized phase II study in renal transplant recipients. Am J Transplant 2011; 11: 1444.
5. Kovarik JM, Steiger JU, Grinyo JM, et al. Pharmacokinetics of sotrastaurin combined with tacrolimus or mycophenolic acid in de novo kidney transplant recipients. Transplantation 2011; 91: 317.