Exposing unethical human research: The transatlantic correspondence of Beecher and Pappworth

Annals of Internal Medicine

Volumn 156, Issue 2, 2012, Pages 150-155

  Gaw, Allan ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; AUTHOR; CLINICAL RESEARCH; HUMAN; MEDICAL LITERATURE; PRIORITY JOURNAL; PUBLICATION; RESEARCH ETHICS; SHAME; UNETHICAL HUMAN RESEARCH; WHISTLEBLOWING;

EID: 84855833379     PISSN: 00034819     EISSN: 15393704     Source Type: Journal    
DOI: 10.7326/0003-4819-156-2-201201170-00012     Document Type: Article

References (44)

1. Beecher HK. Ethics and clinical research. N Engl J Med. 1966;274:1354-60. [PMID: 5327352]
2. Pappworth MH. Human Guinea Pigs: Experimentation on Man. London: Routledge and Kegan Paul; 1967.
3. Harkness J, Lederer SE, Wikler D. Laying ethical foundations for clinical research. Bull World Health Organ. 2001;79:365-6. [PMID: 11357216]
4. Kopp VJ. Henry Knowles Beecher and the development of informed consent in anesthesia research. Anesthesiology. 1999;90:1756-65. [PMID: 10360876]
5. Beecher HK. Experimentation in man. J Am Med Assoc. 1959;169:461-78. [PMID: 13620495]
6. Booth C. Obituary: M H Pappworth MD, FRCP. Br Med J. 1994;309;1577.
7. Emanuel EJ, Grady C, Robert A, Crouch RA, Lie RK, Miller FG, et al. Oxford Textbook of Clinical Research Ethics. New York: Oxford Univ Pr; 2008.
8. Pappworth MH. Human guinea pigs: a warning. Twentieth Century. 1962; 171:66-75.
9. Pappworth MH. "Human guinea pigs"-a history. BMJ. 1990;301:1456-60. [PMID: 2279175]
10. Beecher HK. Letter to MH Pappworth. 7 January 1965. PP/MHP/C5. Wellcome Library, London.
11. Besterman EM. The cardiac output in acute rheumatic carditis. Br Heart J. 1954;16:8-12. [PMID: 13126353]
12. Bearn AG, Billing BH, Sherlock S. Hepatic glucose output and hepatic insulin sensitivity in diabetes mellitus. Lancet. 1951;2:698-701. [PMID: 14874483]
13. Bearn AG, Billing BH, Sherlock S. The response of the liver to insulin in normal subjects and in diabetes mellitus; hepatic vein catheterisation studies. Clin Sci (Lond). 1952;11:152-65. [PMID: 14936289]
14. Phear EA, Sherlock S, Summerskill WH. Blood-ammonium levels in liver disease and hepatic coma. Lancet. 1955;268:836-40. [PMID: 14368880]
15. Dawson AM, Rosenthal WS, De Groote J, Sherlock S. Blood pyruvic-acid and alpha-keto-glutaric acid levels in liver disease and hepatic coma. Lancet. 1957;269:392-6.
16. White LP, Phear EA, Summerskill WH, Sherlock S. Ammonium tolerance in liver disease: observations based on catheterization of the hepatic veins. J Clin Invest. 1955;34:158-68. [PMID: 13233339]
17. Phear EA, Ruebner B, Sherlock S, Summerskill WH. Methionine toxicity in liver disease and its prevention by chlortetracycline. Clin Sci (Lond). 1956;15:93-117. [PMID: 13317120]
18. Dawson AM, De Groote J, Rosenthal WA, Sherlock S. The effects of diamox ammonia metabolism in liver disease. Clin Sci (Lond). 1957;16:413-20. [PMID: 13473155]
19. Read AE, Laidlaw J, Haslam RM, Sherlock S. Neuropsychiatric complications following chlorothiazide therapy in patients with hepatic cirrhosis: possible relation to hypokalaemia. Clin Sci. 1959;18:409-23. [PMID: 14436696]
20. Nordin BE, Fraser R. A calcium-infusion test: I. Urinary excretion data for recognition of osteomalacia. Lancet. 1956;267:823-6.
21. Rudolph AM, Cayler GG. Cardiac catheterization in infants and children. Pediatr Clin North Am. 1958;5:907-43. [PMID: 13600902]
22. Zollinger RM Jr, Lindem MC, Filler RM, Corson JM, Wilson RE. Effect of thymectomy on skin-homograft survival in children. N Engl J Med. 1964;270: 707-10. [PMID: 14101067]
23. Reichman S, Davis WD, Storaasli JP, Gorlin R. Measurement of hepatic blood flow by indicator dilution techniques. J Clin Invest. 1958;37:1848-56. [PMID: 13611052]
24. Derrick JR, Eggers GW, Leonard JJ, Paley HW. A technique for simultaneous pressure determination in the left and right sides of the heart. Am Heart J. 1960;59:442-5. [PMID: 13855713]
25. McHenry LC, Fazekas JF, Sullivan JF. Cerebral hemodynamics of syncope. Am J Med Sci. 1961;241:173-8. [PMID: 13773997]
26. Mackie JE, Stormont JM, Hollister RM, Davidson CS. Production of impending hepatic coma by chlorothiazide und its prevention by antibiotics. N Engl J Med. 1958;259:1151-6. [PMID: 13613481]
27. Webster LT, Davidson CS. Production of impending hepatic coma by a carbonic anhydrase inhibitor, diamox. Proc Soc Exp Biol Med. 1956;91:27-31. [PMID: 13297699]
28. Pappworth MH. Letter to HK Beecher. 19 January 1965. Henry K. Beecher Papers (H MS c64), Harvard Medical Library in the Francis A. Countway Library of Medicine, box 11, folder 55.
29. Beecher HK. Letter to MH Pappworth. 25 January 1965, PP/MHP/C5. Wellcome Library, London.
30. Rothman DJ. The doctor as whistle-blower. In: Rothman DJ. Strangers at the Bedside: How Law and Bioethics Transformed Medical Decision Making. New Brunswick, NJ: Basic Books; 1991:70-84.
31. Osmundsen JA. Physician scores tests on humans; he asserts experiments are done without consent. New York Times. 24 March 1965:35.
32. Beecher HK. Letter to George Burch. 27 June 1966. Quoted in: Rothman DJ. Strangers at the Bedside: How Law and Bioethics Transformed Medical Decision Making. New Brunswick, NJ: Basic Books; 1991;72.
33. Pappworth MH. Letter to HK Beecher. 20 February 1965. Henry K. Beecher Papers (H MS c64), Harvard Medical Library in the Francis A. Count- way Library of Medicine, box 11, folder 55.
34. Beecher HK. Letter to MH Pappworth. 9 March 1965. PP/MHP/C5. Wellcome Library, London.
35. Pappworth MH. Letter to HK Beecher. 25 March 1966. Henry K. Beecher Papers (H MS c64), Harvard Medical Library in the Francis A. Countway Library of Medicine, box 11, folder 55.
36. Beecher HK. Letter to MH Pappworth. 28 March 1966. PP/MHP/C5. Wellcome Library, London.
37. Bunker JP. Commentary on "Ethics and clinical research." In: Doyal L, Tobias JS, eds. Informed Consent and Medical Research. London: BMJ Books; 2001:37-8.
38. Beecher HK. Letter to MH Pappworth. 11 July 1966. PP/MHP/C5. Wellcome Library, London.
39. Beecher HK. Letter to MH Pappworth. 29 July 1966. PP/MHP/C5. Wellcome Library, London.
40. Eastwood M. Medical classics: human guinea pigs. BMJ. 2009;339:b5113.
41. Campbell A. Are the rights of the hospital patient being respected? Hospital Times. 1970;4 Sep:4-5.
42. Beecher HK. Ethics and the explosion of human experimentation [Unpublished manuscript]. Presented 22 March 1965. Beecher Papers. Harvard Medical Library in the Francis A. Countway Library of Medicine, box 12, folder 1. Quoted in: U.S. Department of Energy. Advisory Committee on Human Radiation Experiments Report. 1995. Accessed at www.hss.energy.gov/HealthSafety/ohre/roadmap/achre/index.html on 18 June 2011.
43. Lasagna L. Interview by Jon M. Harkness and Suzanne White-Junod (ACHRE). Transcript of audio recording, 13 December 1994. ACHRE Research Project Series, Interview Program File, Ethics Oral History Project, 5. Accessed at www.hss.energy.gov/HealthSafety/ohre/roadmap/achre/chap2_fn.html#fn29 on 1 July 2011.
44. Schmidt U. Post-war medical ethics. In: Schmidt U. Justice at Nuremberg. Leo Alexander and the Nazi Doctors' Trial. New York: Palgrave Macmillan; 2006:264-97.