Chitosan enhances the stability and targeting of immuno-nanovehicles to cerebro-vascular deposits of Alzheimer's disease amyloid protein

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 8, Issue 2, 2012, Pages 250-260

  Jaruszewski, Kristen M ^a   Ramakrishnan, Subramanian ^b   Poduslo, Joseph F ^c   Kandimalla, Karunya K ^a,c  

^a FLORIDA A AND M UNIVERSITY   (United States)

^b FAMU FSU COLLEGE OF ENGINEERING   (United States)

^c MAYO GRADUATE SCHOOL   (United States)

Author keywords

Blood brain barrier; Cerebral amyloid angiopathy; Cerebrovascular delivery; Colloidal stability; Immuno nanovehicle

Indexed keywords

BLOOD-BRAIN BARRIER; CEREBRAL AMYLOID ANGIOPATHY; CEREBROVASCULAR DELIVERY; COLLOIDAL STABILITY; IMMUNO-NANOVEHICLE;

ANTIBODIES; BLOOD; CHITOSAN; DEPOSITS; NANOPARTICLES; NEURODEGENERATIVE DISEASES;

GLYCOPROTEINS;

AMYLOID ANTIBODY; AMYLOID PROTEIN; ANTIBODY; CHITOSAN; NANOPARTICLE; POLYGLACTIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD VESSEL; CONJUGATION; FREEZE DRYING; IN VITRO STUDY; MEASUREMENT; PROTEIN TARGETING; THEORY;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANTIBODIES, ANTI-IDIOTYPIC; BLOOD-BRAIN BARRIER; CEREBRAL AMYLOID ANGIOPATHY; CHITOSAN; DIAGNOSTIC IMAGING; HUMANS; NANOPARTICLES;

EID: 84855824804     PISSN: 15499634     EISSN: 15499642     Source Type: Journal    
DOI: 10.1016/j.nano.2011.06.008     Document Type: Article

References (28)

1. Calhoun M.E., Burgermeister P., Phinney A.L., Stalder M., Tolnay M., Wiederhold K.H., et al. Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid. Proc Natl Acad Sci U S A 1999, 96:14088-14093.
2. Ulbrich K., Hekmatara T., Herbert E., Kreuter J. Transferrin- and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood-brain barrier (BBB). Eur J Pharm Biopharm 2009, 71:251-256.
3. Chang J., Jallouli Y., Kroubi M., Yuan X.B., Feng W., Kang C.S., et al. Characterization of endocytosis of transferrin-coated PLGA nanoparticles by the blood-brain barrier. Int J Pharm 2009, 379:285-292.
4. Agyare E.K., Curran G.L., Ramakrishnan M., Yu C.C., Poduslo J.F., Kandimalla K.K. Development of a smart nano-vehicle to target cerebrovascular amyloid deposits and brain parenchymal plaques observed in Alzheimer's disease and cerebral amyloid angiopathy. Pharm Res 2008, 25:2674-2684.
5. Muro S., Garnacho C., Champion J.A., Leferovich J., Gajewski C., Schuchman E.H. wt al. Control of endothelial targeting and intracellular delivery of therapeutic enzymes by modulating the size and shape of ICAM-1-targeted carriers. Mol Ther 2008, 16:1450-1458.
6. Rensen P.C., de Vrueh R.L., Kuiper J., Bijsterbosch M.K., Biessen E.A., van Berkel T.J. Recombinant lipoproteins: lipoprotein-like lipid particles for drug targeting. Adv Drug Deliv Rev 2001, 47:251-276.
7. Poduslo J.F., Ramakrishnan M., Holasek S.S., Ramirez-Alvarado M., Kandimalla K.K., Gilles E.J., et al. In vivo targeting of antibody fragments to the nervous system for Alzheimer's disease immunotherapy and molecular imaging of amyloid plaques. J Neurochem 2007, 102:420-433.
8. Banks W.A., Akerstrom V., Kastin A.J. Adsorptive endocytosis mediates the passage of HIV-1 across the blood-brain barrier: evidence for a post-internalization coreceptor. J Cell Sci 1998, 111:533-540.
9. Kandimalla K.K., Wengenack T.M., Curran G.L., Gilles E.J., Poduslo J.F. Pharmacokinetics and amyloid plaque targeting ability of a novel peptide-based magnetic resonance contrast agent in wild-type and Alzheimer's disease transgenic mice. J Pharmacol Exp Ther 2007, 322:541-549.
10. Ramakrishnan M., Kandimalla K.K., Wengenack T.M., Howell K.G., Poduslo J.F. Surface plasmon resonance binding kinetics of Alzheimer's disease amyloid beta peptide-capturing and plaque-binding monoclonal antibodies. Biochemistry 2009, 48:10405-10415.
11. Ramakrishnan M., Wengenack T.M., Kandimalla K.K., Curran G.L., Gilles E.J., Ramirez-Alvarado M., et al. Selective contrast enhancement of individual Alzheimer's disease amyloid plaques using a polyamine and Gd-DOTA conjugated antibody fragment against fibrillar Abeta42 for magnetic resonance molecular imaging. Pharm Res 2008, 25:1861-1872.
12. Yang R., Shim W.S., Cui F.D., Cheng G., Han X., Jin Q.R., et al. Enhanced electrostatic interaction between chitosan-modified PLGA nanoparticle and tumor. Int J Pharm 2009, 371:142-147.
13. Yang R., Yang S.G., Shim W.S., Cui F., Cheng G., Kim I.W., et al. Lung-specific delivery of paclitaxel by chitosan-modified PLGA nanoparticles via transient formation of microaggregates. J Pharm Sci 2009, 98:970-984.
14. Muzzarelli R.A. Colorimetric determination of chitosan. Anal Biochem 1998, 260:255-257.
15. Wischke C., Borchert H.H. Increased sensitivity of chitosan determination by a dye binding method. Carbohydr Res 2006, 341:2978-2979.
16. Irvine J.D., Takahashi L., Lockhart K., Cheong J., Tolan J.W., Selick H.E., et al. MDCK (Madin-Darby canine kidney) cells: a tool for membrane permeability screening. J Pharm Sci 1999, 88:28-33.
17. Corrigan O.I., Li X. Quantifying drug release from PLGA nanoparticulates. Eur J Pharm Sci 2009, 37:477-485.
18. Qaddoumi M.G., Ueda H., Yang J., Davda J., Labhasetwar V., Lee V.H. The characteristics and mechanisms of uptake of PLGA nanoparticles in rabbit conjunctival epithelial cell layers. Pharm Res 2004, 21:641-648.
19. Zhao J., Liu C.S., Yuan Y., Tao X.Y., Shan X.Q., Sheng Y., et al. Preparation of hemoglobin-loaded nano-sized particles with porous structure as oxygen carriers. Biomaterials 2007, 28:1414-1422.
20. Sheng Y., Liu C., Yuan Y., Tao X., Yang F., Shan X., et al. Long-circulating polymeric nanoparticles bearing a combinatorial coating of PEG and water-soluble chitosan. Biomaterials 2009, 30:2340-2348.
21. Guo C., Gemeinhart R.A. Understanding the adsorption mechanism of chitosan onto poly(lactide-co-glycolide) particles. Eur J Pharm Biopharm 2008, 70:597-604.
22. Abdelwahed W., Degobert G., Stainmesse S., Fessi H. Freeze-drying of nanoparticles: formulation, process and storage considerations. Adv Drug Deliv Rev 2006, 58:1688-1713.
23. Abdelwahed W., Degobert G., Fessi H. A pilot study of freeze drying of poly(epsilon-caprolactone) nanocapsules stabilized by poly(vinyl alcohol): formulation and process optimization. Int J Pharm 2006, 309:178-188.
24. Aumelas A., Serrero A., Durand A., Dellacherie E., Leonard M. Nanoparticles of hydrophobically modified dextrans as potential drug carrier systems. Colloids Surf B Biointerfaces 2007, 59:74-80.
25. Kim D.G., Jeong Y.I., Choi C., Roh S.H., Kang S.K., Jang M.K., et al. Retinol-encapsulated low molecular water-soluble chitosan nanoparticles. Int J Pharm 2006, 319:130-138.
26. Pillai C.K.S., Paul W., Sharma C.P. Chitin and chitosan polymers: chemistry, solubility and fiber formation. Prog Polym Sci 2009, 34:641-678.
27. Zhang K., Rossin R., Hagooly A., Chen Z., Welch M.J., Wooley K.L. Folate-mediated Cell Uptake of Shell-crosslinked Spheres and Cylinders. J Polym Sci A Polym Chem 2008, 46:7578-7583.
28. Russel W.B., Saville D.A., Schowalter W.R. Colloidal dispersions 1992, Cambridge University Press, Cambridge.