Necrotizing peripheral vasculitis/vasculopathy following the use of cocaine laced with levamisole

Journal of Burn Care and Research

Volumn 33, Issue 1, 2012, Pages

  Farmer, Russell W ^a   Malhotra, Paula S ^b   Mays, Michael P ^a   Egger, Michael E ^a   Smith, Jason W ^a   Jortani, Saeed A ^a   Spiller, Henry ^c   Bosse, George M ^a   Callen, Jeffrey P ^b   Franklin, Glen A ^a  

^a University of Louisville School of Medicine   (United States)

^b Division of Dermatology   (United States)

^c KENTUCKY REGIONAL POISON CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; COCAINE; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M; INFUSION FLUID; LEVAMISOLE; NEUTROPHIL CYTOPLASMIC ANTIBODY; SULFADIAZINE SILVER; WARFARIN;

ADULT; AGRANULOCYTOSIS; ALCOHOL ABUSE; ANALGESIA; ANTIBODY TITER; ARTHRALGIA; ARTICLE; ASTHMA; BODY SURFACE; CASE REPORT; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONGESTIVE HEART FAILURE; DEBRIDEMENT; ELECTROCARDIOGRAM; ELECTROLYTE INTAKE; ERYTHEMA; ERYTHROCYTE; EXTRAVASATION; FATIGUE; FEVER; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPERTENSION; IMMUNOGLOBULIN BLOOD LEVEL; INGESTION; LABORATORY TEST; LAW ENFORCEMENT; LYMPHOCYTIC INFILTRATION; MALE; MASS SPECTROMETRY; NECROTIZING ARTERITIS; ORCHIECTOMY; PALPATION; PURPURA; SHOULDER; SKIN BIOPSY; SKIN EXFOLIATION; SKIN INFLAMMATION; SKIN NECROSIS; SPLIT THICKNESS SKIN GRAFT; SUBCUTANEOUS FAT; THROMBOSIS; UNITED STATES; WOUND DRESSING;

COCAINE; COCAINE-RELATED DISORDERS; DEBRIDEMENT; DRUG COMBINATIONS; DRUG CONTAMINATION; FOLLOW-UP STUDIES; HUMANS; LEVAMISOLE; MALE; MIDDLE AGED; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; SKIN TRANSPLANTATION; VASCULITIS, LEUKOCYTOCLASTIC, CUTANEOUS; WOUND HEALING;

EID: 84855799111     PISSN: 1559047X     EISSN: 15590488     Source Type: Journal    
DOI: 10.1097/BCR.0b013e318235615a     Document Type: Article

References (21)

1. DHHS. National Survery on Drug Use and Health 2002/ 2003. 2004; available from http://www.oas.samhsa.gov/ Nhsda/2k3tabs/Sect1peTabs1to66.htm#tab1.1a.; Internet; accessed August 27, 2010.
2. DHHS. Results from the 2008 National Survey on Drug Use and Health: National Findings. 2009; available from http:// oas.samhsa.gov/nsduh/2k8nsduh/ 2k8Results.cfm; Internet; accessed August 2, 2010.
3. Raymon LP, Isenschmid DS. Letter to the editor: the possible role of levamisole in illicit cocaine preparations. J Anal Toxicol 2009;33:620-2.
4. Fabrizi F, Dixit V, Messa P, Martin P. Meta-analysis: levamisole improves the immune response to hepatitis B vaccine in dialysis patients. Aliment Pharmacol Ther 2010;32:756-62.
5. Rongioletti F, Ghio L, Ginevri F, et al. Purpura of the ears: a distinctive vasculopathy with circulating autoantibodies complicating long-term treatment with levamisole in children. Br J Dermatol 1999;140:948-51. (Pubitemid 29238474)
6. Laux-End R, Inaebnit D, Gerber HA, Bianchetti MG. Vasculitis associated with levamisole and circulating autoantibodies. Arch Dis Child 1996;75:355-6. (Pubitemid 26354616)
7. Scheinberg MA, Bezerra JB, Almeida FA, Silveira LA. Cutaneous necrotising vasculitis induced by levamisole. Br Med J 1978;1:408. (Pubitemid 8318799)
8. SAMHSA. Nationwide Public Health Alert Issued Concerning Life-Threatening Risk Posed by Cocaine Laced with Veterinary Anti-Parasite Drug. 2009 9/21/2009; available from http:// www.samhsa.gov/newsroom/advisories/090921vet5101. aspx; Internet; accessed August 27, 2010.
9. Buchanan JA, Vogel JA, Eberhardt AM. Levamisole-induced occlusive necrotizing vasculitis of the ears after use of cocaine contaminated with levamisole. J Med Toxicol 2011;7:83-4.
10. Waller JM, Feramisco JD, Alberta-Wszolek L, McCalmont TH, Fox LP. Cocaine-associated retiform purpura and neurtopenia: is levamisole the culprit? J Am Acad Dermatol 2010;63:530-5.
11. Bradford M, Rosenberg B, Moreno J, Dumyati G. Bilateral necrosis of earlobes and cheeks: another complication of cocaine contaminated with levamisole. Ann Intern Med 2010; 152:758-9.
12. Walsh NM, Green PJ, Burlingame RW, Pasternak S, HanlyJG. Cocaine-related retiform purpura: evidence to incriminate the adulterant, levamisole. J Cutan Pathol 2010;37: 1212-9.
13. Jufer RA, Wstadik A, Walsh SL, Levine BS, Cone EJ. Elimination of cocaine and metabolites in plasma, saliva, and urine following repeated oral administration to human volunteers. J Anal Toxicol 2000;24:467-77.
14. Walsh NM, Green PJ, Burlingame RW, Pasternak S, Hanly JG. Cocaine-related retiform purpura: evidence to incriminate the adulterant, levamisole. J Cutan Pathol 2010;37: 1212-9.
15. Friedman DR, Wolfsthal SD. Cocaine-induced pseudovasculitis. Mayo Clin Proc 2005;80:671-3. (Pubitemid 40628824)
16. Hofbauer GF, Burg G, Nestle FO. Cocaine-related Stevens- Johnson syndrome. Dermatology 2000;201:258-60.
17. Orriols R, Munoz X, Ferrer J, Huget P, Morell F. Cocaineinduced Churg-Strauss vasculitis. Eur Respir J 1996;9: 175-7.
18. Czuchlewski DR, Brackney M, Ewers C, et al. Clinicopathologic features of agranulocytosis in the setting of levamisoletainted cocaine. Am J Clin Pathol 2010;133:466-72.
19. Zhu NY, Legatt DF, Turner AR. Agranulocytosis after consumption of cocaine adulterated with levamisole. Ann Intern Med 2009;150:287-9.
20. Knowles L, Buxton JA, Skuridina N, et al. Levamisole tainted cocaine causing severe neutropenia in Alberta and British Columbia. Harm Reduct J 2009;6:30.
21. CDC. Agranulocytosis associated with cocaine use-four States, March 2008-November 2009. MMWR Morb Mortal Wkly Rep 2009;58:1381-5.