HIV infection and HERV expression: A review

Retrovirology

Volumn 9, Issue , 2012, Pages

  van der Kuyl, Antoinette C ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3G; DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; EFAVIRENZ; GAG PROTEIN; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; INTEGRASE; NEVIRAPINE; POL PROTEIN; RNA DIRECTED DNA POLYMERASE; VIRUS ENVELOPE PROTEIN; VIRUS RNA; VIRUS PROTEIN;

CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; ENDOGENOUS RETROVIRUS; GENE EXPRESSION; GENETIC COMPLEMENTATION; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN T CELL LEUKEMIA VIRUS 1; LONG TERMINAL REPEAT; NONHUMAN; OPPORTUNISTIC INFECTION; REVIEW; SEROCONVERSION; UPREGULATION; VIREMIA; VIRION; VIRUS ACTIVATION; VIRUS DNA CELL DNA INTERACTION; VIRUS GENOME; VIRUS LOAD; VIRUS REPLICATION; BIOSYNTHESIS; CYTOTOXIC T LYMPHOCYTE; GENETIC TRANSCRIPTION; IMMUNOLOGY; PATHOGENICITY; PROVIRUS;

HUMAN IMMUNODEFICIENCY VIRUS; LENTIVIRUS; PRIMATES; SPUMAVIRUS;

CD8-POSITIVE T-LYMPHOCYTES; ENDOGENOUS RETROVIRUSES; HIV INFECTIONS; HUMANS; PROVIRUSES; T-LYMPHOCYTES, CYTOTOXIC; TRANSCRIPTION, GENETIC; VIRAL PROTEINS; VIRUS ACTIVATION;

EID: 84855798495     PISSN: None     EISSN: 17424690     Source Type: Journal    
DOI: 10.1186/1742-4690-9-6     Document Type: Review

References (87)

1. Weiss RA. The discovery of endogenous retroviruses. Retrovirology 2006, 3:67. 10.1186/1742-4690-3-67, 1617120, 17018135.
2. Kurth R, Bannert N. Beneficial and detrimental effects of human endogenous retroviruses. Int J Cancer 2010, 126:306-314. 10.1002/ijc.24902, 19795446.
3. Nethe M, Berkhout B, van der Kuyl AC. Retroviral superinfection resistance. Retrovirology 2005, 2:52. 10.1186/1742-4690-2-52, 1224871, 16107223.
4. Blomberg J, Benachenhou F, Blikstad V, Sperber G, Mayer J. Classification and nomenclature of endogenous retroviral sequences (ERVs): problems and recommendations. Gene 2009, 448:115-123. 10.1016/j.gene.2009.06.007, 19540319.
5. Mayer J, Meese E. Human endogenous retroviruses in the primate lineage and their influence on host genomes. Cytogenet Genome Res 2005, 110:448-456. 10.1159/000084977, 16093697.
6. Beimforde N, Hanke K, Ammar I, Kurth R, Bannert N. Molecular cloning and functional characterization of the human endogenous retrovirus K113. Virology 2008, 371:216-225. 10.1016/j.virol.2007.09.036, 18076964.
7. Ruprecht K, Ferreira H, Flockerzi A, Wahl S, Sauter M, Mayer J, et al. Human endogenous retrovirus family HERV-K(HML-2) RNA transcripts are selectively packaged into retroviral particles produced by the human germ cell tumor line Tera-1 and originate mainly from a provirus on chromosome 22q11.21. J Virol 2008, 82:10008-10016. 10.1128/JVI.01016-08, 2566279, 18684837.
8. Seifarth W, Skladny H, Krieg-Schneider F, Reichert A, Hehlmann R, Leib-Mosch C. Retrovirus-like particles released from the human breast cancer cell line T47-D display type B- and C-related endogenous retroviral sequences. J Virol 1995, 69:6408-6416. 189540, 7545247.
9. Dewannieux M, Harper F, Richaud A, Letzelter C, Ribet D, Pierron G, et al. Identification of an infectious progenitor for the multiple-copy HERV-K human endogenous retroelements. Genome Res 2006, 16:1548-1556. 10.1101/gr.5565706, 1665638, 17077319.
10. Lee YN, Bieniasz PD. Reconstitution of an infectious human endogenous retrovirus. PLoS Pathog 2007, 3:e10. 10.1371/journal.ppat.0030010, 1781480, 17257061.
11. van der Kuyl AC, Cornelissen M, Berkhout B. Of mice and men: on the origin of XMRV. Frontiers in Microbiology 2010, 1:147. 3109487, 21687768.
12. Paprotka T, Delviks-Frankenberry KA, Cingoz O, Martinez A, Kung HJ, Tepper CG, et al. Recombinant origin of the retrovirus XMRV. Science 2011, 333:97-101. 10.1126/science.1205292, 21628392.
13. Gifford RJ, Katzourakis A, Tristem M, Pybus OG, Winters M, Shafer RW. A transitional endogenous lentivirus from the genome of a basal primate and implications for lentivirus evolution. Proc Natl Acad Sci USA 2008, 105:20362-20367. 10.1073/pnas.0807873105, 2603253, 19075221.
14. Gilbert C, Maxfield DG, Goodman SM, Feschotte C. Parallel germline infiltration of a lentivirus in two Malagasy lemurs. PLoS Genet 2009, 5:e1000425. 10.1371/journal.pgen.1000425, 2651035, 19300488.
15. Switzer WM, Bhullar V, Shanmugam V, Cong ME, Parekh B, Lerche NW, et al. Frequent simian foamy virus infection in persons occupationally exposed to nonhuman primates. J Virol 2004, 78:2780-2789. 10.1128/JVI.78.6.2780-2789.2004, 353775, 14990698.
16. Calattini S, Betsem EB, Froment A, Mauclere P, Tortevoye P, Schmitt C, et al. Simian foamy virus transmission from apes to humans, rural Cameroon. Emerg Infect Dis 2007, 13:1314-1320. 2857270, 18252101.
17. Jones-Engel L, May CC, Engel GA, Steinkraus KA, Schillaci MA, Fuentes A, et al. Diverse contexts of zoonotic transmission of simian foamy viruses in Asia. Emerg Infect Dis 2008, 14:1200-1208. 2562341,2562341, 18680642.
18. Cordonnier A, Casella JF, Heidmann T. Isolation of novel human endogenous retrovirus-like elements with foamy virus-related pol sequence. J Virol 1995, 69:5890-5897. 189468, 7543594.
19. Priet S, Gros N, Navarro JM, Boretto J, Canard B, Querat G, et al. HIV-1-associated uracil DNA glycosylase activity controls dUTP misincorporation in viral DNA and is essential to the HIV-1 life cycle. Mol Cell 2005, 17:479-490. 10.1016/j.molcel.2005.01.016, 15721252.
20. Yan N, O'Day E, Wheeler LA, Engelman A, Lieberman J. HIV DNA is heavily uracilated, which protects it from autointegration. Proc Natl Acad Sci USA 2011, 108:9244-9249. 10.1073/pnas.1102943108, 3107311, 21576478.
21. McIntosh EM, Haynes RH. HIV and human endogenous retroviruses: an hypothesis with therapeutic implications. Acta Biochim Pol 1996, 43:583-592.
22. Towler EM, Gulnik SV, Bhat TN, Xie D, Gustschina E, Sumpter TR, et al. Functional characterization of the protease of human endogenous retrovirus, K10: can it complement HIV-1 protease?. Biochemistry 1998, 37:17137-17144. 10.1021/bi9818927, 9860826.
23. Padow M, Lai L, Fisher RJ, Zhou YC, Wu X, Kappes JC, et al. Analysis of human immunodeficiency virus type 1 containing HERV-K protease. AIDS Res Hum Retroviruses 2000, 16:1973-1980. 10.1089/088922200750054701, 11153080.
24. Ogata T, Okui N, Sakuma R, Kobayashi N, Kitamura Y. Integrase of human endogenous retrovirus K-10 supports the replication of replication-incompetent Int- human immunodeficiency virus type 1 mutant. Jpn J Infect Dis 1999, 52:251-252.
25. Mi S, Lee X, Li X, Veldman GM, Finnerty H, Racie L, et al. Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis. Nature 2000, 403:785-789. 10.1038/35001608, 10693809.
26. Blond JL, Lavillette D, Cheynet V, Bouton O, Oriol G, Chapel-Fernandes S, et al. An envelope glycoprotein of the human endogenous retrovirus HERV-W is expressed in the human placenta and fuses cells expressing the type D mammalian retrovirus receptor. J Virol 2000, 74:3321-3329. 10.1128/JVI.74.7.3321-3329.2000, 111833, 10708449.
27. An DS, Xie Y, Chen IS. Envelope gene of the human endogenous retrovirus HERV-W encodes a functional retrovirus envelope. J Virol 2001, 75:3488-3489. 10.1128/JVI.75.7.3488-3489.2001, 114144, 11238877.
28. Lusso P, di M, Ensoli B, Franchini G, Jemma C, DeRocco SE, et al. Expanded HIV-1 cellular tropism by phenotypic mixing with murine endogenous retroviruses. Science 1990, 247:848-852. 10.1126/science.2305256, 2305256.
29. Yang J, Bogerd HP, Peng S, Wiegand H, Truant R, Cullen BR. An ancient family of human endogenous retroviruses encodes a functional homolog of the HIV-1 Rev protein. Proc Natl Acad Sci USA 1999, 96:13404-13408. 10.1073/pnas.96.23.13404, 23960, 10557333.
30. Rimsky L, Hauber J, Dukovich M, Malim MH, Langlois A, Cullen BR, et al. Functional replacement of the HIV-1 rev protein by the HTLV-1 rex protein. Nature 1988, 335:738-740. 10.1038/335738a0, 3262832.
31. Sakai H, Siomi H, Shida H, Shibata R, Kiyomasu T, Adachi A. Functional comparison of transactivation by human retrovirus rev and rex genes. J Virol 1990, 64:5833-5839. 248742, 1700826.
32. Iversen AK, Shpaer EG, Rodrigo AG, Hirsch MS, Walker BD, Sheppard HW, et al. Persistence of attenuated rev genes in a human immunodeficiency virus type 1-infected asymptomatic individual. J Virol 1995, 69:5743-5753. 189435, 7637019.
33. Saurya S, Lichtenstein Z, Karpas A. Defective rev response element (RRE) and rev gene in HAART treated AIDS patients with discordance between viral load and CD4+ T-cell counts. J Clin Virol 2005, 33:324-327. 10.1016/j.jcv.2005.05.003, 16005679.
34. Churchill MJ, Chiavaroli L, Wesselingh SL, Gorry PR. Persistence of attenuated HIV-1 rev alleles in an epidemiologically linked cohort of long-term survivors infected with nef-deleted virus. Retrovirology 2007, 4:43. 10.1186/1742-4690-4-43, 1933581, 17601342.
35. Rulli SJ, Jr Hibbert CS, Mirro J, Pederson T, Biswal S, Rein A. Selective and nonselective packaging of cellular RNAs in retrovirus particles. J Virol 2007, 81:6623-6631. 10.1128/JVI.02833-06, 1900105, 17392359.
36. Houzet L, Paillart JC, Smagulova F, Maurel S, Morichaud Z, Marquet R, et al. HIV controls the selective packaging of genomic, spliced viral and cellular RNAs into virions through different mechanisms. Nucleic Acids Res 2007, 35:2695-2704. 10.1093/nar/gkm153, 1885669, 17426127.
37. Didierlaurent L, Racine PJ, Houzet L, Chamontin C, Berkhout B, Mougel M. Role of HIV-1 RNA and protein determinants for the selective packaging of spliced and unspliced viral RNA and host U6 and 7SL RNA in virus particles. Nucleic Acids Res 2011, 39:8915-8927. 10.1093/nar/gkr577, 3203606, 21791531.
38. Zeilfelder U, Frank O, Sparacio S, Schon U, Bosch V, Seifarth W, et al. The potential of retroviral vectors to cotransfer human endogenous retroviruses (HERVs) from human packaging cell lines. Gene 2007, 390:175-179. 10.1016/j.gene.2006.08.019, 17045761.
39. Contreras-Galindo R, Lopez P, Velez R, Yamamura Y. HIV-1 infection increases the expression of human endogenous retroviruses type K (HERV-K) in vitro. AIDS Res Hum Retroviruses 2007, 23:116-122. 10.1089/aid.2006.0117, 17263641.
40. Contreras-Galindo R, Kaplan MH, Markovitz DM, Lorenzo E, Yamamura Y. Detection of HERV-K(HML-2) viral RNA in plasma of HIV type 1-infected individuals. AIDS Res Hum Retroviruses 2006, 22:979-984. 10.1089/aid.2006.22.979, 17067267.
41. Garrison KE, Jones RB, Meiklejohn DA, Anwar N, Ndhlovu LC, Chapman JM, et al. T cell responses to human endogenous retroviruses in HIV-1 infection. PLoS Pathog 2007, 3:e165. 10.1371/journal.ppat.0030165, 2065876, 17997601.
42. Contreras-Galindo RA, Kaplan MH, Contreras-Galindo AC, Gonzalez-Hernandez M, Ferlengui I, Giusti F, et al. Characterization of human endogenous retroviral elements in the blood of HIV-1-infected individuals. J Virol 2012, 86(1):262-76. 10.1128/JVI.00602-11, 22031938.
43. Laderoute MP, Giulivi A, Larocque L, Bellfoy D, Hou Y, Wu HX, et al. The replicative activity of human endogenous retrovirus K102 (HERV-K102) with HIV viremia. AIDS 2007, 21:2417-2424. 10.1097/QAD.0b013e3282f14d64, 18025878.
44. Lefebvre G, Desfarges S, Uyttebroeck F, Munoz M, Beerenwinkel N, Rougemont J, et al. Analysis of HIV-1 expression level and sense of transcription by high-throughput sequencing of the infected cell. J Virol 2011, 85:6205-6211. 10.1128/JVI.00252-11, 3126515, 21507965.
45. Johnston JB, Silva C, Holden J, Warren KG, Clark AW, Power C. Monocyte activation and differentiation augment human endogenous retrovirus expression: implications for inflammatory brain diseases. Ann Neurol 2001, 50:434-442. 10.1002/ana.1131, 11601494.
46. Contreras-Galindo R, Gonzalez M, Almodovar-Camacho S, Gonzalez-Ramirez S, Lorenzo E, Yamamura Y. A new real-time-RT-PCR for quantitation of human endogenous retroviruses type K (HERV-K) RNA load in plasma samples: increased HERV-K RNA titers in HIV-1 patients with HAART non-suppressive regimens. J Virol Methods 2006, 136:51-57. 10.1016/j.jviromet.2006.03.029, 16678919.
47. Contreras-Galindo R, Almodovar-Camacho S, Gonzalez-Ramirez S, Lorenzo E, Yamamura Y. Comparative longitudinal studies of HERV-K and HIV-1 RNA titers in HIV-1-infected patients receiving successful versus unsuccessful highly active antiretroviral therapy. AIDS Res Hum Retroviruses 2007, 23:1083-1086. 10.1089/aid.2007.0054, 17919102.
48. Oude Essink BB, Das AT, Berkhout B. HIV-1 reverse transcriptase discriminates against non-self tRNA primers. J Mol Biol 1996, 264:243-254. 10.1006/jmbi.1996.0638, 8951374.
49. Abbink TE, Beerens N, Berkhout B. Forced selection of a human immunodeficiency virus type 1 variant that uses a non-self tRNA primer for reverse transcription: involvement of viral RNA sequences and the reverse transcriptase enzyme. J Virol 2004, 78:10706-10714. 10.1128/JVI.78.19.10706-10714.2004, 516392, 15367637.
50. Mangiacasale R, Pittoggi C, Sciamanna I, Careddu A, Mattei E, Lorenzini R, et al. Exposure of normal and transformed cells to nevirapine, a reverse transcriptase inhibitor, reduces cell growth and promotes differentiation. Oncogene 2003, 22:2750-2761. 10.1038/sj.onc.1206354, 12747369.
51. Sciamanna I, Landriscina M, Pittoggi C, Quirino M, Mearelli C, Beraldi R, et al. Inhibition of endogenous reverse transcriptase antagonizes human tumor growth. Oncogene 2005, 24:3923-3931. 10.1038/sj.onc.1208562, 15806170.
52. Jones RB, Garrison KE, Wong JC, Duan EH, Nixon DF, Ostrowski MA. Nucleoside analogue reverse transcriptase inhibitors differentially inhibit human LINE-1 retrotransposition. PLoS ONE 2008, 3:e1547. 10.1371/journal.pone.0001547, 2212136, 18253495.
53. Rowe HM, Trono D. Dynamic control of endogenous retroviruses during development. Virology 2011, 411:273-287. 10.1016/j.virol.2010.12.007, 21251689.
54. Lavie L, Kitova M, Maldener E, Meese E, Mayer J. CpG methylation directly regulates transcriptional activity of the human endogenous retrovirus family HERV-K(HML-2). J Virol 2005, 79:876-883. 10.1128/JVI.79.2.876-883.2005, 538560, 15613316.
55. Blazkova J, Trejbalova K, Gondois-Rey F, Halfon P, Philibert P, Guiguen A, et al. CpG methylation controls reactivation of HIV from latency. PLoS Pathog 2009, 5:e1000554. 10.1371/journal.ppat.1000554, 2722084, 19696893.
56. Lenasi T, Contreras X, Peterlin BM. Transcriptional interference antagonizes proviral gene expression to promote HIV latency. Cell Host Microbe 2008, 4:123-133. 10.1016/j.chom.2008.05.016, 18692772.
57. Duverger A, Jones J, May J, Bibollet-Ruche F, Wagner FA, Cron RQ, et al. Determinants of the establishment of human immunodeficiency virus type 1 latency. J Virol 2009, 83:3078-3093. 10.1128/JVI.02058-08, 2655589, 19144703.
58. Richman DD, Margolis DM, Delaney M, Greene WC, Hazuda D, Pomerantz RJ. The challenge of finding a cure for HIV infection. Science 2009, 323:1304-1307. 10.1126/science.1165706, 19265012.
59. Lewinski MK, Bisgrove D, Shinn P, Chen H, Hoffmann C, Hannenhalli S, et al. Genome-wide analysis of chromosomal features repressing human immunodeficiency virus transcription. J Virol 2005, 79:6610-6619. 10.1128/JVI.79.11.6610-6619.2005, 1112149, 15890899.
60. Schroder AR, Shinn P, Chen H, Berry C, Ecker JR, Bushman F. HIV-1 integration in the human genome favors active genes and local hotspots. Cell 2002, 110:521-529. 10.1016/S0092-8674(02)00864-4, 12202041.
61. Toufaily C, Landry S, Leib-Mosch C, Rassart E, Barbeau B. Activation of LTRs from different human endogenous retrovirus (HERV) families by the HTLV-1 Tax protein and T-cell activators. Viruses 2011, 3:2146-2159. 10.3390/v3112146, 3230845, 22163338.
62. Depil S, Roche C, Dussart P, Prin L. Expression of a human endogenous retrovirus, HERV-K, in the blood cells of leukemia patients. Leukemia 2002, 16:254-259. 10.1038/sj.leu.2402355, 11840292.
63. Griffiths PD. Herpesviruses and AIDS. J Antimicrob Chemother 1996, 37(Suppl B):87-95.
64. Lee WJ, Kwun HJ, Kim HS, Jang KL. Activation of the human endogenous retrovirus W long terminal repeat by herpes simplex virus type 1 immediate early protein 1. Mol Cells 2003, 15:75-80.
65. Ruprecht K, Obojes K, Wengel V, Gronen F, Kim KS, Perron H, et al. Regulation of human endogenous retrovirus W protein expression by herpes simplex virus type 1: implications for multiple sclerosis. J Neurovirol 2006, 12:65-71. 10.1080/13550280600614973, 16595376.
66. Nellaker C, Yao Y, Jones-Brando L, Mallet F, Yolken RH, Karlsson H. Transactivation of elements in the human endogenous retrovirus W family by viral infection. Retrovirology 2006, 3:44. 10.1186/1742-4690-3-44, 1539011, 16822326.
67. Sutkowski N, Conrad B, Thorley-Lawson DA, Huber BT. Epstein-Barr virus transactivates the human endogenous retrovirus HERV-K18 that encodes a superantigen. Immunity 2001, 15:579-589. 10.1016/S1074-7613(01)00210-2, 11672540.
68. Tai AK, Luka J, Ablashi D, Huber BT. HHV-6A infection induces expression of HERV-K18-encoded superantigen. J Clin Virol 2009, 46:47-48. 10.1016/j.jcv.2009.05.019, 19505843.
69. Turcanova VL, Bundgaard B, Hollsberg P. Human herpesvirus-6B induces expression of the human endogenous retrovirus K18-encoded superantigen. J Clin Virol 2009, 46:15-19. 10.1016/j.jcv.2009.05.015, 19505847.
70. SenGupta D, Tandon R, Vieira RG, Ndhlovu LC, Lown-Hecht R, Ormsby CE, et al. Strong human endogenous retrovirus-specific T cell responses are associated with control of HIV-1 in chronic infection. J Virol 2011, 85:6977-6985. 10.1128/JVI.00179-11, 3126607, 21525339.
71. Lee YN, Malim MH, Bieniasz PD. Hypermutation of an ancient human retrovirus by APOBEC3G. J Virol 2008, 82:8762-8770. 10.1128/JVI.00751-08, 2519637, 18562521.
72. Armitage AE, Katzourakis A, de OT, Welch JJ, Belshaw R, Bishop KN, et al. Conserved footprints of APOBEC3G on hypermutated human immunodeficiency virus type 1 and human endogenous retrovirus HERV-K(HML2) sequences. J Virol 2008, 82:8743-8761. 10.1128/JVI.00584-08, 2519685, 18562517.
73. Vogetseder W, Dumfahrt A, Mayersbach P, Schonitzer D, Dierich MP. Antibodies in human sera recognizing a recombinant outer membrane protein encoded by the envelope gene of the human endogenous retrovirus K. AIDS Res Hum Retroviruses 1993, 9:687-694. 10.1089/aid.1993.9.687, 8396402.
74. Boller K, Janssen O, Schuldes H, Tonjes RR, Kurth R. Characterization of the antibody response specific for the human endogenous retrovirus HTDV/HERV-K. J Virol 1997, 71:4581-4588. 191680, 9151852.
75. Goedert JJ, Sauter ME, Jacobson LP, Vessella RL, Hilgartner MW, Leitman SF, et al. High prevalence of antibodies against HERV-K10 in patients with testicular cancer but not with AIDS. Cancer Epidemiol Biomarkers Prev 1999, 8:293-296.
76. Lower R, Lower J, Kurth R. The viruses in all of us: characteristics and biological significance of human endogenous retrovirus sequences. Proc Natl Acad Sci USA 1996, 93:5177-5184. 10.1073/pnas.93.11.5177, 39218, 8643549.
77. Stevens RW, Baltch AL, Smith RP, McCreedy BJ, Michelsen PB, Bopp LH, et al. Antibody to human endogenous retrovirus peptide in urine of human immunodeficiency virus type 1-positive patients. Clin Diagn Lab Immunol 1999, 6:783-786. 95775, 10548563.
78. Lawoko A, Johansson B, Rabinayaran D, Pipkorn R, Blomberg J. Increased immunoglobulin G, but not M, binding to endogenous retroviral antigens in HIV-1 infected persons. J Med Virol 2000, 62:435-444. 10.1002/1096-9071(200012)62:4<435::AID-JMV7>3.0.CO;2-R, 11074471.
79. Jern P, Sperber GO, Blomberg J. Use of endogenous retroviral sequences (ERVs) and structural markers for retroviral phylogenetic inference and taxonomy. Retrovirology 2005, 2:50. 10.1186/1742-4690-2-50, 1224870, 16092962.
80. Tandon R, SenGupta D, Ndhlovu LC, Vieira RG, Jones RB, York VA, et al. Identification of human endogenous retrovirus (HERV)-specific T cell responses in vertically HIV-1-infected subjects. J Virol 2011, 85:11526-11531. 10.1128/JVI.05418-11, 3194955, 21880743.
81. Schiavetti F, Thonnard J, Colau D, Boon T, Coulie PG. A human endogenous retroviral sequence encoding an antigen recognized on melanoma by cytolytic T lymphocytes. Cancer Res 2002, 62:5510-5516.
82. Takahashi Y, Harashima N, Kajigaya S, Yokoyama H, Cherkasova E, McCoy JP, et al. Regression of human kidney cancer following allogeneic stem cell transplantation is associated with recognition of an HERV-E antigen by T cells. J Clin Invest 2008, 118:1099-1109. 2248804, 18292810.
83. NCBI nucleotide database. , http://www.ncbi.nlm.nih.gov/nucleotide/
84. BioEdit Sequence Alignment Editor version 7.0.9. , http://www.mbio.ncsu.edu/BioEdit/bioedit.html
85. MEGA 5 software package. , http://www.megasoftware.net/
86. van der Kuyl AC. Characterization of a full-length endogenous beta-retrovirus, EqERV-beta1, in the genome of the horse (Equus caballus). Viruses 2011, 3:620-628. 10.3390/v3060620, 3185775, 21994749.
87. Armbruester V, Sauter M, Krautkraemer E, Meese E, Kleiman A, Best B, et al. A novel gene from the human endogenous retrovirus K expressed in transformed cells. Clin Cancer Res 2002, 8:1800-1807.