In vitro and in vivo study of cucurbitacins-type triterpene glucoside from Citrullus colocynthis growing in Saudi Arabia against hepatocellular carcinoma

Environmental Toxicology and Pharmacology

Volumn 33, Issue 2, 2012, Pages 245-251

  Ayyad, Seif Eldin N ^a   Abdel Lateff, Ahmed ^a   Alarif, Walied M ^a   Patacchioli, Francesca R ^b   Badria, Farid A ^c   Ezmirly, Saleh T ^a  

^a KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c MANSOURA UNIVERSITY   (Egypt)

Author keywords

Anticancer; Citrullus colocynthis; Cucurbitaceae HepG2; Cucurbitacins; EAC

Indexed keywords

CUCURBITACIN; CUCURBITACIN E GLUCOSIDE; CUCURBITACIN I GLUCOSIDE; FLUOROURACIL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL STRAIN HEPG2; CHEMICAL STRUCTURE; CHROMATOGRAPHY; COLOCYNTH; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG STRUCTURE; EHRLICH ASCITES TUMOR; ELECTROSPRAY MASS SPECTROMETRY; FRUIT; HETERONUCLEAR MULTIPLE BOND CORRELATION; IC 50; IN VITRO STUDY; IN VIVO STUDY; ISOLATION PROCEDURE; LIFESPAN; LIVER CELL CARCINOMA; MALE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SAUDI ARABIA; SURVIVAL TIME;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CARCINOMA, EHRLICH TUMOR; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; CHROMATOGRAPHY, THIN LAYER; CITRULLUS; CUCURBITACINS; DOSE-RESPONSE RELATIONSHIP, DRUG; FRUIT; HEP G2 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; LIVER NEOPLASMS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MOLECULAR STRUCTURE; PLANTS, MEDICINAL; SAUDI ARABIA; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TIME FACTORS; TRITERPENES;

CITRULLUS COLOCYNTHIS; CUCURBITACEAE; HUMAN ECHOVIRUS 1; MUS;

EID: 84855791985     PISSN: 13826689     EISSN: 18727077     Source Type: Journal    
DOI: 10.1016/j.etap.2011.12.010     Document Type: Article

References (23)

1. Abdel-Wahab B.F., Awad G.h.E.A., Badria F.A. Synthesis, antimicrobial, antioxidant, anti-hemolytic and cytotoxic evaluation of new imidazole-based heterocycles. Eur. J. Med. Chem. 2011, 46:1505.
2. Abu-Hashemi A.A., El-Shehery M.F., Badria F.A. Design and synthesis of novel thiophenecarbohydrazide, thienopyrazole and thienopyrimidine derivatives as antioxidant and antitumor agents. Acta Pharm. 2010, 60:311.
3. Afifi M.S., Ross S.A., Elsohly M.A., Naeem Z.E., Halawelshi F.T. Cucurbitacins of Cucumis prophetarum and Cucumis prophetarum. J. Chem. Ecol. 1999, 25:847.
4. Atta-Ur-Rahman A., Ahmed V.U., Khan M.A., Zehra F. Isolation and structure of cucurbitacin. Phytochemistry 1973, 12:2741.
5. Badria F., Ameen M., Akl M. Evaluation of cytotoxic compounds from Calligonum comosum L. growing in Egypt. Z. Naturforsch. 2007, 62:656.
6. Badria F., Dawidar A., Houssen W., Wayne T.S. In vitro Study of flavonoids, fatty acids, steroids on proliferation of rat hepatic stellate cells. Z. Naturforsch. 2005, 60c:139.
7. Badria F., El-Gayar A., El-Kashef H., El-Baz M. A potent hepatoprotective agent from grape fruit. Alex. J. Pharm. Sci. 1994, 8:165.
8. Badria F., ElGayyar M. A new type of tyrosinase inhibitors from natural products as potential treatments for hyperpigmentation. Bull. Chim. Farmac. 2001, 140:267.
9. Badria F. Is man helpless against cancer? An environmental approach: antimutagenic agents from egyptian food and medicinal preparations. Cancer Lett. 1994, 84:1.
10. Bar-nun N., Mayer A.M. Cucurbitacins-repressor of induction of lacase formation. Phytochemistry 1989, 28:1369.
11. Bartalis J., Halaweish F.T. In vitro and QSAR studies of cucurbitacins on HepG2 and HSC-T6 liver cell lines. Bioorg. Med. Chem. 2011, 19:2757.
12. Chang J.C. A review of breast cancer chemoprevention. Biomed. Pharmacother. 1998, 52:133.
13. Choudhury S.M., Gupta M., Majumder U.K. Antineoplastic activities of MT81 and its structural analogue in Ehrlich ascites carcinoma-bearing swiss albino mice. Oxid. Med. Cell. Longev. 2010, 3:61.
14. El-Subbagh H., Abu-Zaid M., Mahran M., Badria F., Al-obaid A. Synthesis and biological evaluation of certain α,β-unsaturated ketones and their corresponding fused pyridines as antiviral and cytotoxic agents. J. Med. Chem. 2000, 43:2915.
15. Fuller R.W., Cardellina J.H., Cragg G.M., Body M.R. Cucurbitacin: differential cytotoxicity, dereplication and first isolation from Gonystylus keithii. J. Nat. Prod. 1994, 57:1442.
16. Gallily R., Shohat B., Kalish J., Gitter S., Lavie D. Further studies on the antitumor effect of Cucurbitacins. Cancer Res. 1962, 22:1038.
17. Lavie D., Glotter E. The cucurbitacins, a group of tetracyclic triterpenes. Fortschr. Chem. Org. Naturst. 1971, 29:307.
18. Miró M. Cucurbitacins and their pharmacological effects. Phytother. Res. 1995, 9:159.
19. Musza L.L., Speight P., Mcelhiney S., Brown C.T., Gillum A.M., Cooper R., Killer L.M. Cucurbitacins: cell adhesion inhibitor from Conobea scoparioides. J. Nat. Prod. 1994, 57:1498.
20. Natiq A.R.H., Donald A.W., Nahia J.Y. Cucurbitacin glycosides from Citrullus colocynthis. Phytochemistry 1989, 28:1268.
21. Parker S.L., Tong T., Bolden S., Wingo P.A. Cancer statistics. Cancer J. Clin. 1997, 47:5.
22. Torkey H.M., Abou-Yousef H.M., Abdel Azeiz A.Z., Hoda E.A.F. Insecticidal effect of cucurbitacin E glycoside isolated from Citrullus colocynthis against Aphis craccivora. Aust. J. Basic Appl. Sci. 2009, 3:4060.
23. Wang J., Zhou X., Cao Y., Xiao J., Ma E., Deng Y., Chen D. The antitumor activities of cucurbitacin liposome for injection. Asian J. Tradit. Med. 2007, 2:98.