Impact of influenza virus adaptation status on HA N-glycosylation patterns in cell culture-based vaccine production

Journal of Carbohydrate Chemistry

Volumn 30, Issue 4-6, 2011, Pages 281-290

  Rödig, Jana ^a   Rapp, Erdmann ^a   Djeljadini, Suzana ^a   Lohr, Verena ^a   Genzel, Yvonne ^a   Jordan, Ingo ^b   Sandig, Volker ^b   Reichl, Udo ^c  

^a MAX PLANCK INSTITUTE FOR DYNAMICS OF COMPLEX TECHNICAL SYSTEMS   (Germany)

^b PROBIOGEN AG   (Germany)

^c OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

HA; Hemagglutinin; Influenza a virus; N glycosylation; Virus adaptation

Indexed keywords

INFLUENZA A VIRUS; INFLUENZAVIRUS A; ORTHOMYXOVIRIDAE;

EID: 84855790406     PISSN: 07328303     EISSN: 15322327     Source Type: Journal    
DOI: 10.1080/07328303.2011.604454     Document Type: Article

References (21)

1. Gerdil, C. The annual production cycle for influenza vaccine. Vaccine 2003, 21(16), 1776-1779. (Pubitemid 36398372)
2. Sandig, V.; Jordan, I. Immortalized cell lines for virus production. 2005, WO 2005/042728 A2.
3. Guehenneux, F.; Moreau, K.; Esnault, M.; Mehtali, M. Duck embryonic derived stem cell lines for the production of viral vaccines. 2008, US 2010/0062489 A1.
4. Brown, S. W.; Mehtali, M. The avian EB66 (R) cell line, application to vaccines, and therapeutic protein production. PDA J. Pharm. Sci. Technol. 2010, 64(5), 419-425.
5. ® as candidates for MVA and influenza vaccine production. In: Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Culture Technology (ESACT). Edited by Jenkins, N. Dublin, Ireland: Springer Science+Buisiness Media B. V.; 2011.
6. Jordan, I.; Northoff, S.; Thiele, M.; Hartmann, S.; Horn, D.; Howing, K.; Bernhardt, H.; Oehmke, S.; von Horsten, H.; Rebeski, D.; Hinrichsen, L.; Zelnik, V.; Mueller, W.; Sandig, V. A chemically defined production process for highly attenuated poxviruses. Biologicals 2011, 39(1), 50-58.
7. Kalbfuss, B.; Knochlein, A.; Krober, T.; Reichl, U. Monitoring influenza virus content in vaccine production: precise assays for the quantitation of hemagglutination and neuraminidase activity. Biologicals 2008, 36(3), 145-161. (Pubitemid 351508423)
8. Schwarzer, J.; Rapp, E.; Reichl, U. N-glycan analysis by CGE-LIF: profiling influenza A virus hemagglutinin N-glycosylation during vaccine production. Electrophoresis 2008, 29(20), 4203-4214.
9. Schwarzer, J.; Rapp, E.; Hennig, R.; Genzel, Y.; Jordan, I.; Sandig, V.; Reichl, U. Glycan analysis in cell culture-based influenza vaccine production: influence of host cell line and virus strain on the glycosylation pattern of viral hemagglutinin. Vaccine 2009, 27(32), 4325-4336.
10. Ruhaak, L. R.; Hennig, R.; Huhn, C.; Borowiak, M.; Dolhain, R. J.; Deelder, A. M.; Rapp, E.; Wuhrer, M. Optimized workflow for preparation of APTS-labeled N-glycans allowing high-throughput analysis of human plasma glycomes using 48-channel multiplexed CGE-LIF. J. Proteome Res. 2010, 9(12), 6655-6664.
11. Ishii, H.; Yoshikawa, Y.; Yamanouchi, K. Adaptation of the lapinized rinderpest virus to in vitro growth and attenuation of its virulence in rabbits. J. Gen. Virol. 1986, 67 (Pt 2) : 275-280. (Pubitemid 16180256)
12. Wallis, C. M.; Stone, A. L.; Sherman, D. J.; Damsteegt, V. D.; Gildow, F. E.; Schneider, W. L. Adaptation of plum pox virus to a herbaceous host (Pisum sativum) following serial passages. J. Gen. Virol. 2007, 88 (Pt 10), 2839-2845. (Pubitemid 47555039)
13. Genzel, Y.; Dietzsch, C.; Rapp, E.; Schwarzer, J.; Reichl, U. MDCK and vero cells for influenza virus vaccine production: a one-to-one comparison up to lab-scale bioreactor cultivation. Appl. Microbiol. Biotechnol. 2010, 88(2), 461-475.
14. Domingo, E.; Martin, V.; Perales, C.; Grande-Perez, A.; Garcia-Arriaza, J.; Arias, A. Viruses as quasispecies: biological implications. Curr. Top. Microbiol. Immunol. 2006, 299, 51-82. (Pubitemid 43086561)
15. Tsuchiya, E.; Sugawara, K.; Hongo, S.; Matsuzaki, Y.; Muraki, Y; Li, Z. N.; Nakamura, K. Effect of addition of new oligosaccharide chains to the globular head of influenza A/H2N2 virus haemagglutinin on the intracellular transport and biological activities of the molecule. J. Gen. Virol. 2002, 83 (Pt 5), 1137-1146. (Pubitemid 34477287)
16. Deshpande, K. L.; Fried, V. A.; Ando, M.; Webster, R. G. Glycosylation affects cleavage of an H5N2 influenza virus hemagglutinin and regulates virulence. Proc. Natl. Acad. Sci. USA 1987, 84(1), 36-40. (Pubitemid 17013573)
17. Wang, C. C.; Chen, J. R.; Tseng, Y. C.; Hsu, C. H.; Hung, Y. F.; Chen, S. W.; Chen, CM.; Khoo, K. H.; Cheng, T. J.; Cheng, Y. S.; Jan, J. T.; Wu, C. Y.; Ma, C; Wong, C. H.; Glycans on influenza hemagglutinin affect receptor binding and immune response. Proc. Natl. Acad. Sci. USA 2009, 106(43), 18137-18142.
18. Klenk, H. D.; Wagner, R.; Heuer, D.; Wolff, T. Importance of hemagglutinin glycosylation for the biological functions of influenza virus. Virus Res. 2002, 82(1-2), 73-75. (Pubitemid 34273715)
19. Wagner, R.; Heuer, D.; Wolff, T.; Herwig, A.; Klenk, H. D. N-Glycans attached to the stem domain of haemagglutinin efficiently regulate influenza A virus replication. J. Gen. Virol. 2002, 83 (Pt 3), 601-609. (Pubitemid 34183005)
20. Deng, K.; Adams, M. M.; Damani, P.; Livingston, P. O.; Ragupathi, G.; Gin, D. Y. Synthesis of QS-21-xylose: establishment of the immunopotentiating activity of synthetic QS-21 adjuvant with a melanoma vaccine. Angew Chem. Int. Ed. Engl. 2008, 47, 6395-6398.
21. Boonyarattanakalin, S.; Liu, X.; Michieletti, M.; Lepenies, B.; Seeberger, P. H. Chemical synthesis of all phosphatidylinositol mannoside (PIM) glycans from Mycobacterium tuberculosis. J. Am. Chem. Soc. 2008, 130, 16791-16799.