Anti-AIDS agents 85. Design, synthesis, and evaluation of 1R,2R-dicamphanoyl-3,3-dimethyldihydropyrano-[2,3-c]xanthen-7(1H)-one (DCX) derivatives as novel anti-HIV agents

European Journal of Medicinal Chemistry

Volumn 47, Issue 1, 2012, Pages 86-96

  Zhou, Ting ^a   Shi, Qian ^a   Chen, Chin Ho ^b   Huang, Li ^b   Ho, Phong ^b   Morris Natschke, Susan L ^a   Lee, Kuo Hsiung ^a,c  

^a University of North Carolina   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

1R,2R dicamphanoyl 3,3 dimethydihydropyrano 2,3 c xanthen 7(1H) one (DCX); Anti HIV activity; Structure activity relationship (SAR)

Indexed keywords

1,2 DICAMPHANOYL 3,3 DIMETHYL 1,2 DIHYDROPYRANO [2,3 C]XANTHEN 7 (1H)ONE; 1,2 DICAMPHANOYL 3,3 DIMETHYL 5 BROMO 6 METHOXY 1,2 DIHYDROPYRANO[2,3 C]XANTHEN 7 (1H)ONE; 1,2 DICAMPHANOYL 3,3 DIMETHYL 6 HYDROXY 1,2 DIHYDROPYRANO[2,3 C]XANTHEN 7 (1H)ONE; 1,2 DICAMPHANOYL 3,3 DIMETHYL 6 HYDROXY 9 BROMOMETHYL 1,2 DIHYDROPYRANO[2,3 C]XANTHEN 7 (1H)ONE; 1,2 DICAMPHANOYL 3,3 DIMETHYL 6 METHOXY 1,2 DIHYDROPYRANO[2,3 C]XANTHEN 7 (1H)ONE; 1,2 DICAMPHANOYL 3,3 DIMETHYL 6 METHOXY 1,2 DIHYDROPYRANO[2,3 C]XANTHEN 7 (1H)ONE OXIME; 1,2 DICAMPHANOYL 3,3 DIMETHYL 6 METHOXY 10 BROMO 1,2 DIHYDROPYRANO[2,3 C]XANTHEN 7 (1H)ONE; 1,2 DICAMPHANOYL 3,3 DIMETHYL 6 METHOXY 10 CYANO 1,2 DIHYDROPYRANO[2,3 C]XANTHEN 7 (1H)ONE; 1,2 DICAMPHANOYL 3,3 DIMETHYL 6 METHOXY 8 HYDROXY 1,2 DIHYDROPYRANO[2,3 C]XANTHEN 7 (1H)ONE; 1,2 DICAMPHANOYL 3,3 DIMETHYL 6 METHOXY 9 CYANO 1,2 DIHYDROPYRANO[2,3 C]XANTHEN 7 (1H)ONE; 1,2 DICAMPHANOYL 3,3 DIMETHYL 6,10 DIMETHOXY 1,2 DIHYDROPYRANO[2,3 C]XANTHEN 7 (1H)ONE; 1,2 DICAMPHANOYL 3,3 DIMETHYL 6,11 DIMETHOXY 1,2 DIHYDROPYRANO[2,3 C]XANTHEN 7 (1H)ONE; 1,2 DICAMPHANOYL 3,3 DIMETHYL 6,8 DIMETHOXY 1,2 DIHYDROPYRANO[2,3 C]XANTHEN 7 (1H)ONE; 1,2 DICAMPHANOYL 3,3 DIMETHYL 6,9 DIMETHOXY 1,2 DIHYDROPYRANO[2,3 C]XANTHEN 7 (1H)ONE; 1,2 DICAMPHANOYL 3,3 DIMETHYL 9 BROMO 6 METHOXY 1,2 DIHYDROPYRANO[2,3 C]XANTHEN 7 (1H)ONE; 1,2 DICAMPHANOYL 3,3 TRIMETHYL 6 METHOXY 11 FLUORO 1,2 DIHYDROPYRANO[2,3 C]XANTHEN 7 (1H)ONE; 1,2 DICAMPHANOYL 3,3 TRIMETHYL 6 METHOXY 8 FLUORO 1,2 DIHYDROPYRANO[2,3 C]XANTHEN 7 (1H)ONE; 1,2 DICAMPHANOYL 3,3 TRIMETHYL 6 METHOXY 9 FLUORO 1,2 DIHYDROPYRANO[2,3 C]XANTHEN 7 (1H)ONE; 1,2 DICAMPHANOYL 3,3,10 TRIMETHYL 6 METHOXY 1,2 DIHYDROPYRANO[2,3 C]XANTHEN 7 (1H)ONE; 1,2 DICAMPHANOYL 3,3,11 TRIMETHYL 6 METHOXY 1,2 DIHYDROPYRANO[2,3 C]XANTHEN 7 (1H)ONE; 1,2 DICAMPHANOYL 3,3,8 TRIMETHYL 6 METHOXY 1,2 DIHYDROPYRANO[2,3 C]XANTHEN 7 (1H)ONE; 1,2 DICAMPHANOYL 3,3,8 TRIMETHYL 6,10 DIMETHOXY 1,2 DIHYDROPYRANO[2,3 C]XANTHEN 7 (1H)ONE; 1,2 DICAMPHANOYL 3,3,9 TRIMETHYL 5 BROMO 6 METHOXY 1,2 DIHYDROPYRANO[2,3 C]XANTHEN 7 (1H)ONE; 1,2 DICAMPHANOYL 3,3,9 TRIMETHYL 6 METHOXY 1,2 DIHYDROPYRANO[2,3 C]XANTHEN 7 (1H)ONE; 2 ETHYL 3',4'DI O CAMPHANOYL 2',2' DIMETHYLDIHYDROPYRANO[2,3 F]CHROMONE; ANTIVIRUS AGENT; COUMARIN DERIVATIVE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANTIVIRAL ACTIVITY; ANTIVIRAL RESISTANCE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; VIRUS ATTACHMENT; VIRUS INFECTIVITY; VIRUS STRAIN;

ANTI-HIV AGENTS; CAMPHOR; DRUG DESIGN; DRUG RESISTANCE, VIRAL; HIV-1; XANTHENES;

EID: 84855782604     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.10.025     Document Type: Article

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