Survival despite extremely high plasma diltiazem level in a case of acute poisoning treated by the molecular-adsorbent recirculating system

European Journal of Emergency Medicine

Volumn 19, Issue 1, 2012, Pages 59-61

  Belleflamme, Marie ^a   Hantson, Philippe ^a,b   Gougnard, Thierry ^c   Minon, Jean Marc ^c   Wittebole, Xavier ^a   Laterre, Pierre François ^a   Mairesse, Jacques ^d   Dugernier, Thierry ^d  

^a CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^c Centre Hospitalier Regional de La Citadelle   (Belgium)

^d Clinique Saint Pierre of Ottignies   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; CALCIUM SALT; DILTIAZEM; HYPERTENSIVE FACTOR; NORADRENALIN; OROSOMUCOID; PHENYLEPHRINE; VASOACTIVE AGENT;

ADRENAL FUNCTION; ADULT; AGED; ALBUMIN DIALYSIS; ANURIA; AORTA BALLOON; ARTIFICIAL VENTILATION; CASE REPORT; CONTINUOUS HEMOFILTRATION; DETOXIFICATION; DISEASE COURSE; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG FORMULATION; DRUG HALF LIFE; DRUG INTOXICATION; DRUG OVERDOSE; EXTRACORPOREAL CIRCULATION; FEMALE; HEMOPERFUSION; HUMAN; HYPERINSULINEMIA; HYPOGLYCEMIA; HYPOTENSION; HYPOXEMIA; LACTATE BLOOD LEVEL; LACTIC ACIDOSIS; LETTER; MEDICAL CARE; PRIORITY JOURNAL; SHOCK; SURVIVAL; SUSTAINED DRUG RELEASE; VASOPLEGIA;

ACIDOSIS, LACTIC; ACUTE DISEASE; AGED; ANTIHYPERTENSIVE AGENTS; DELAYED-ACTION PREPARATIONS; DILTIAZEM; FEMALE; HEMODYNAMICS; HUMANS; OVERDOSE; VASOPLEGIA;

EID: 84855766221     PISSN: 09699546     EISSN: 14735695     Source Type: Journal    
DOI: 10.1097/MEJ.0b013e3283474a9f     Document Type: Letter

References (5)

1. Roper TA, Sykes R, Gray C. Fatal diltiazem overdose: report of four cases and review of the literature. Postgrad Med J 1993; 69:474-476. (Pubitemid 23193985)
2. Belpaire FM, Bogaert MG. Binding of diltiazem to albumin, alpha 1-acid glycoprotein and to serum in man. J Clin Pharmacol 1990; 30:311-317. (Pubitemid 20274108)
3. Pichon N, Francois B, Clavel M, Vignon P, Chevreuil C, Gaulier JM. Albumin dialysis: a new therapeutic alternative for severe diltiazem intoxication. Clin Toxicol 2006; 44:195-196. (Pubitemid 44112957)
4. Luomanmäki K, Tiula E, Kivistö KT, Neuvonen PJ. Pharmacokinetics of diltiazem in massive overdose. Ther Drug Monit 1997; 19: 240242. (Pubitemid 28056041)
5. Levine M, Boyer EW, Pozner CN, Geib AJ, Thomsen T, Mick N, et al. Assessment of hyperglycemia after calcium channel blocker overdoses involving diltiazem or verapamil. Crit Care Med 2007; 35:2071-2075. (Pubitemid 47326443)