Signaling transduction analysis in gingival epithelial cells after infection with Aggregatibacter actinomycetemcomitans

Molecular Oral Microbiology

Volumn 27, Issue 1, 2012, Pages 23-33

  Umeda, J E ^a   Demuth, D R ^b   Ando, E S ^a   Faveri, M ^c   Mayer, M P A ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF LOUISVILLE   (United States)

^c GUARULHOS UNIVERSITY   (Brazil)

Author keywords

Aggregatibacter actinomycetemcomitans; Epithelial cell; Gene expression; Infection

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AGGREGATIBACTER ACTINOMYCETEMCOMITANS; AGGREGATIBACTER ACTINOMYCETEMCOMITANS INFECTION; APOPTOSIS; ARTICLE; BACTERIAL INFECTION; CELL ADHESION; CELL INVASION; CHRONIC PERIODONTITIS; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; GINGIVAL EPITHELIAL CELL; HUMAN; HUMAN TISSUE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOCLASTOGENESIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SUPERNATANT;

ACTINOBACILLUS ACTINOMYCETEMCOMITANS; AGGRESSIVE PERIODONTITIS; APOPTOSIS; BACTERIAL ADHESION; CASE-CONTROL STUDIES; CELL LINE, TRANSFORMED; CHRONIC PERIODONTITIS; COLONY-STIMULATING FACTORS; CULTURE MEDIA, CONDITIONED; CYTOKINES; EPITHELIAL CELLS; GENE EXPRESSION PROFILING; GINGIVA; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84855752780     PISSN: 20411006     EISSN: 20411014     Source Type: Journal    
DOI: 10.1111/j.2041-1014.2011.00629.x     Document Type: Article

References (50)

1. Aas, J.A., Paster, B.J., Stokes, L.N., Olsen, I. and Dewhirst, F.E. (2005) Defining the normal bacterial flora of the oral cavity. J Clin Microbiol 43: 5721-5732.
2. Abdel-Latif, M.M.M., Windle, H.J., Fitzgerald, K.A. et al. (2004) Helicobacter pylori activates the early growth response 1 protein in gastric epithelial cells. Infect Immun 72: 3549-3560.
3. Ambili, R., Santhi, W.S., Janam, P., Nandakumar, K. and Pilai, M.R. (2005) Expression of activated transcription factor nuclear factor-kappaB in periodontally diseased tissues. J Periodontol 76: 1148-1153.
4. Armitage, G.C. (1999) Development of a classification system for periodontal diseases and conditions. Ann Periodontol 4: 1-6.
5. Baron, V., Adamson, E.D., Calogero, A., Ragona, G. and Mercola, D. (2006) The transcription factor Egr-1 is a direct regulator of multiple tumor suppressors including TGFβ-1, PTEN, p53 and fibronectin. Cancer Gene Ther 13: 115-124.
6. Bloemen, V., Vries, T.J., Shoenmaker, T. and Everts, V. (2009) Intercellular adhesion molecule-1 clusters during osteoclastogenesis. Biochem Biophys Res Commun 385: 640-645.
7. Dale, B.A. (2002) Periodontal epithelium: a newly recognized role in health and disease. Periodontol 2000(30): 70-78.
8. Faveri, M., Figueiredo, L.C., Duarte, P.M., Mestnik, M.J., Mayer, M.P.A. and Feres, M. (2009) Microbiological profile of untreated subjects with localized aggressive periodontitis. J Clin Periodontol 36: 739-749.
9. Feldmann, M. and Maini, R.N. (2003) Lasker clinical medical research award: TNF defined as a therapeutic target for a rheumatoid arthritis and other autoimmune diseases. Nat Med 9: 1245.
10. Feldmann, M., Brennan, F.M., Foxwell, B.M. and Maini, R.N. (2001) The role of TNF-α and IL-1 in rheumatoid arthritis. Curr Dir Autoimmun 3: 188-199.
11. Fukushima, H., Jimi, E., Okamoto, F., Motokawa, W. and Okabe, K. (2005) IL-1-induced receptor activator of NF-κB ligand in human periodontal ligament cells involves ERK-dependent PGE2 production. Bone 36: 267-275.
12. Garlet, G.P., Martins, W. Jr, Ferreira, B.R., Mailanezi, C.M. and Silva, J.S. (2003) Patterns of chemokines and chemokines receptors expression in different forms of human periodontal disease. J Periodontal Res 38: 210-217.
13. Garrison, J.B., Samuel, T. and Reed, J.C. (2009) TRAF2-binding BIR1 domain of c-IAP2/MALT1 fusion protein is essential for activation of NF-κB. Oncogene 28: 1584-1593.
14. Gupta, M., Gupta, S.K., Hoffman, B. and Liebermann, D.A. (2006) Gadd45a and gadd45b protect hematopoietic cells from UV induced apoptosis via distinct signaling pathways including p38 activation and JNK inhibition. J Biol Chem 281: 17552-17558.
15. Hamilton, J.A. (2008) Colony-stimulating factors in inflammation and autoimmunity. Nat Rev Immunol 8: 533-544.
16. Huang, G.T.J., Kinder Haake, S., Kim, J.W. and Park, N.H. (1998) Differential expression of interleukin-8 and intercellular adhesion molecule-1 by human gingival epithelial cells in response to Actinobacillus actinomycetemcomitans or Porphyromonas gingivalis infection. Oral Microbiol Immunol 13: 301-309.
17. Huang, G.T., Zhang, H.B., Dang, H.N. and Haake, S.K. (2004) Differential regulation of cytokines genes in gingival epithelial cells challenged by Fusobacterium nucleatum and Porphyromonas gingivalis. Microb Pathog 37: 303-312.
18. Jia, T., Serbina, N.V., Brandl, K. et al. (2008) Additive roles for MCP-1 and MCP-3 in CCR2-mediated recruitment of inflammatory monocytes during Listeria monocytogenes infection. J Immunol 180: 6846-6853.
19. Jimi, E., Ikebe, T., Takahashi, N., Hirata, M., Suda, T. and Koga, T. (1996) Interleulin-1α activates an NF-κB-like factor in osteoclast-like cells. J Biol Chem 271: 4605-4608.
20. Kajiya, M., Komatsuzawa, H., Papantonakis, A. et al. (2011) Aggregatibacter actinomicetemcomitansOmp29 is associated with bacterial entry to gingival epithelial cells by F-actin rearrangement. PLoS One 6: e18287.
21. Kikkert, R., Laine, M.L., Aarden, L.A. and Van Winkelhoff, A.J. (2007) Activation of toll-like receptors 2 and 4 by gram-negative periodontal bacteria. Oral Microbiol Immunol 22: 145-151.
22. Laube, D.M., Dongari-Bagtzoglou, A., Kashleva, H., Eskadale, J., Gallagher, G. and Diamond, G. (2008) Differential regulation of innate immune response genes in gingival epithelial cells stimulated with Aggregatibacter actinomycetemcomitans. J Periodontal Res 43: 116-123.
23. Lawson, C. and Wolf, S. (2009) ICAM-1 signaling in endothelial cells. Pharmacol Rep 61: 22-32.
24. Liebermann, D.A. and Hoffman, B (2008) Gadd45 in stress signaling. J Mol Signal 12: 3-15.
25. MacDonald, B.R., Mundy, G.R., Clark, S. et al. (1986) Effects of human recombinant CSCM and highly purified CSF-1 on the formation of multi-nucleated cells with osteoclasts characteristics in long term bone marrow cultures. J Bone Min Res 1: 977-985.
26. Maekawa, Y., Takahashi, N., Honda, T. et al. (2010) Porphyromonas gingivalis antigens and interleukin-6 stimulate the production of monocyte chemoattractant protein-1 via the upregulation of early growth response-1 transcription in human coronary artery endothelial cells. J Vasc Res 47: 346-354.
27. Meyer, D.H., Lippmann, J.E. and Fives-Taylor, P.M. (1996) Invasion of epithelial cells by Actinobacillus actinomycetemcomitans: a dynamic, multistep process. Infect Immun 64: 2988-2997.
28. Milward, M.R., Chapple, I.L.C., Wright, H.J., Millard, J.L., Matthews, J.B. and Cooper, P.R. (2007) Differential activation of NF-κB and gene expression in oral epithelial cells by periodontal pathogens. Clin Exp Immunol 148: 307-324.
29. Muhle, I., Rau, J. and Ruskin, J. (1979) Vertebral osteomyelitis due to Actinobacillus actinomycetemcomitans. JAMA 241: 1824-1825.
30. Nichols, T.C., Fischer, T.H., Deljarqvris, E.N. and Baldwin, A.S. Jr (2001) Role of nuclear factor-kappa B (NF-kappa B) inflammation, periodontitis and atherogenesis. Ann Periodontol 6: 20-29.
31. Nomura, K., Kuroda, S., Yoshikawa, H. and Tomita, T. (2008) Inflammatory osteoclastogenesis can be induced by GM-CSF and activated under TNF immunity. Bioch Biophysical Res Comm 367: 881-887.
32. O' Hara, A.M., Bhattacharyya, A., Bai, J. et al. (2009) Tumor necrosis factor (TNF)-α induced IL-8 expression in gastric epithelial cells: role of reactive oxygen species and AD endonuclease-1/redox factor (Ref)-1. Cytokine 46: 359-369.
33. Park, B.K., Zhang, H., Zeng, Q. et al. (2007) NF-κB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF. Nat Med 13: 62-69.
34. Paturel, L., Casalta, J.P., Habib, G., Nezri, M. and Raoult, D. (2004) Actinobacillus actinomycetemcomitans endocarditis. Clin Microbiol Infect 10: 98-118.
35. Polyak, K., Kato, J.Y., Solomon, M.J. et al. (1994) p27kip1, a cyclin-cdk inhibitor, links transforming growth factor-beta and contact and inhibition to cell cycle arrest. Genes Dev 8: 9-22.
36. Pradepp, A.R., Daisy, H., Hadge, P., Grarg, G. and Thorat, M. (2009) Correlation of gingival crevicular fluid interleukin-18 and monocyte chemoattractant protein-1 levels in periodontal health and disease. J Periodontol 80: 1454-1461.
37. Shan, L., He, P. and Sheen, J. (2007) Intercepting host MAPK signaling cascades by bacterial type III effectors. Cell Host Microbe 1: 167-174.
38. Shenker, B.J., Dlakic, M., Walker, L.P. et al. (2007) A novel mode of activation for a microbial-derived immunotoxin: the cytolethal distending toxin subunit B exhibits phosphatidylinositol 3, 4, 5-triphosphate phosphatase activity. J Immunol 178: 5099-5108.
39. Shimada, T., Sugano, N., Nishihara, R., Suzuki, K., Tanaka, H. and Ito, K. (2008) Differential effects of five Aggregatibacter actinomycetemcomitans strains on gingival epithelial cells. Oral Microbiol Immunol 23: 455-458.
40. Silva, N., Dutzan, N., Hernandez, M. et al. (2008) Characterization of progressive lesions in chronic periodontits patients: levels of chemokines, cytokines, matrix metalloproteinase-13, periodontal pathogens and inflammatory cells. J Clin Periodontol 35: 206-214.
41. Slots, J., Reynolds, H.S. and Genco, R. (1980) Actinobacillus actinomycetemcomitans in human periodontal disease: a cross sectional microbiological investigation. Infect Immun 29: 1013-1020.
42. Spehlmann, M.E. and Eckmann, L. (2009) Nuclear factor-kappa B in intestinal protection and destruction. Curr Opin Gastroenterol 25: 92-99.
43. Stathopoulou, P.G, Benakanakere, M.R., Galicia, J.C. and Kinane, D.F. (2010) Epithelial cell proinflammatory cytokine response differs across dental bacterial species. J Clin Periodontol 37: 24-29.
44. Tancharoen, S., Matsuyama, T., Abeyama, K. et al. (2008) The role of water channel aquaporin 3 in the mechanism of TNF-α-mediated proinflammatory events: implication in periodontal inflammation. J Cell Physiol 217: 338-349.
45. Vermes, A.I., Haanen, C., Steffens-Nakken, H. and Reutelingsperger, C. (1995) A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labeled annexinV. J Immunol Methods 184: 39-51.
46. Wang, B., Khachigian, L.M., Esau, L. et al. (2009) A key role for early growth response-1 and nuclear factor-κb in mediating and maintaining gro/cxcr2 proliferative signaling in esophageal cancer. Mol Cancer Res 7: 755-764.
47. Yadav, A., Saini, V. and Sarika, A. (2010) MCP-1: chemoattractant with a role beyond immunity: a review. Clin Chim Acta 411: 1570-1579.
48. Yamamoto, M. and Takeda, K. (2008) Role of nuclear IκB proteins in the regulation of immune responses. J Infect Chemother 14: 265-269.
49. Yoshida, N. and Yoshikawa, T. (2008) Basic and translational research on proteinase-activated receptors: implication of proteinase/proteinase-activated receptor in gastrointestinal inflammation. J Pharmacol Sci 108: 415-421.
50. Zhang, G. and Rudney, J.D. (2011) Streptococcus cristatus attenuates Fusobacterium nucleatum-induced cytokine expression by influencing pathways converging on nuclear factor-κB. Mol Oral Microbiol 26: 150-163.