Mono-methoxy-poly(3-hydroxybutyrate-co-4-hydroxybutyrate)-graft-hyper-branched polyethylenimine copolymers for siRNA delivery

Biomaterials

Volumn 33, Issue 7, 2012, Pages 2334-2344

  Zhou, Li ^a,d   Chen, Zhifei ^a   Chi, Weilin ^a   Yang, Xiuqun ^b   Wang, Wei ^a   Zhang, Biliang ^a,c  

^a GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH   (China)

^b Guangzhou Science Park   (China)

^c GUANGZHOU MEDICAL UNIVERSITY   (China)

^d UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Non viral vector; Poly(ethyleneimine); Poly(hydroxyalkanoates); SiRNA delivery

Indexed keywords

A549 CELLS; BLOCK LENGTHS; CELL LINES; CELLULAR UPTAKE; IN-VITRO; LIPOFECTAMINE; LOW CONCENTRATIONS; LUCIFERASE EXPRESSION; MICHAEL ADDITIONS; NONVIRAL; NONVIRAL VECTORS; POLY(ETHYLENEIMINE); POLYANIONICS; POLYETHYLENIMINES; POLYHYDROXYALKANOATES; SIRNA DELIVERY; TRANSFECTION AGENTS; TRANSFECTION EFFICIENCY;

ADDITION REACTIONS; CELL CULTURE; CELLS; CONFOCAL MICROSCOPY; FLOW CYTOMETRY; GRAFTING (CHEMICAL); LIPOSOMES; MOLECULAR BIOLOGY; RNA;

COPOLYMERS;

COPOLYMER; HEPARIN; LIPOFECTAMINE; LUCIFERASE; MONO METHOXY POLY(3 HYDROXYBUTYRATE CO 4 HYDROXYBUTYRATE); POLYETHYLENEIMINE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; DEGRADATION; FLOW CYTOMETRY; IN VITRO STUDY; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA BINDING; RNA TRANSPORT; SYNTHESIS;

CELL LINE; GENE SILENCING; GENE TRANSFER TECHNIQUES; HYDROXYBUTYRATES; MATERIALS TESTING; MOLECULAR STRUCTURE; PARTICLE SIZE; POLYESTERS; POLYETHYLENEIMINE; POLYMERS; RNA, SMALL INTERFERING;

EID: 84855747908     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.11.060     Document Type: Article

References (37)

1. Elbashir S.M., Harborth J., Lendeckel W., Yalcin A., Weber K., Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001, 411:494-498.
2. Oh Y.K., Park T.G. siRNA delivery systems for cancer treatment. Adv Drug Deliv Rev 2009, 61:850-862.
3. Castanotto D., Rossi J.J. The promises and pitfalls of RNA-interference-based therapeutics. Nature 2009, 457:426-433.
4. Whitehead K.A., Langer R., Anderson D.G. Knocking down barriers: advances in siRNA delivery. Nat Rev Drug Discov 2009, 8:129-138.
5. Mintzer M.A., Simanek E.E. Nonviral vectors for gene delivery. Chem Rev 2009, 109:259-302.
6. Howard K.A. Delivery of RNA interference therapeutics using polycation-based nanoparticles. Adv Drug Deliv Rev 2009, 61:710-720.
7. Boussif O., Lezoualc'h F., Zanta M.A., Mergny M.D., Scherman D., Demeneix B., et al. Aversatile vector for gene and oligonucleotide transfer into cells in culture and invivo: polyethylenimine. Proc Natl Acad Sci U S A 1995, 92:7297-7301.
8. Godbey W.T., Wu K.K., Mikos A.G. Poly(ethylenimine) and its role in gene delivery. JControl Release 1999, 60:149-160.
9. Grayson A.C., Doody A.M., Putnam D. Biophysical and Structural characterization of polyethylenimine-mediated siRNA delivery invitro. Pharm Res 2006, 23:1868-1876.
10. Moghimi S.M., Symonds P., Murray J.C., Hunter A.C., Debska G., Szewczyk A. Atwo-stage poly(ethylenimine)-mediated cytotoxicity: implications for gene transfer/therapy. Mol Ther 2005, 11:990-995.
11. Hunter A.C. Molecular hurdles in polyfectin design and mechanistic background to polycation induced cytotoxicity. Adv Drug Deliv Rev 2006, 58:1523-1531.
12. Thomas M., Klibanov A.M. Enhancing polyethylenimine's delivery of plasmid DNA into mammalian cells. Proc Natl Acad Sci U S A 2002, 99:14640-14645.
13. Doody A.M., Korley J.N., Dang K.P., Zawaneh P.N., Putnam D. Characterizing the structure/function parameter space of hydrocarbon-conjugated branched polyethylenimine for DNA delivery invitro. JControl Release 2006, 116:227-237.
14. Schiffelers R.M., Ansari A., Xu J., Zhou Q., Tang Q., Storm G., et al. Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle. Nucleic Acids Res 2004, 32:e149.
15. Dehshahri A., Oskuee R.K., Shier W.T., Hatefi A., Ramezani M. Gene transfer efficiency of high primary amine content, hydrophobic, alkyl-oligoamine derivatives of polyethylenimine. Biomaterials 2009, 30:4187-4194.
16. Wang C.F., Lin Y.X., Jiang T., He F., Zhuo R.X. Polyethylenimine-grafted polycarbonates as biodegradable polycations for gene delivery. Biomaterials 2009, 30:4824-4832.
17. Qiu L.Y., Bae Y.H. Self-assembled polyethylenimine-graft-poly(epsilon-caprolactone) micelles as potential dual carriers of genes and anticancer drugs. Biomaterials 2007, 28:4132-4142.
18. Rai R., Keshavarz T., Roether J.A., Boccaccini A.R., Roy I. Medium chain length polyhydroxyalkanoates, promising new biomedical materials for the future. Mat Sci Eng R 2011, 72:29-47.
19. Chen G.Q., Wu Q. The application of polyhydroxyalkanoates as tissue engineering materials. Biomaterials 2005, 26:6565-6578.
20. Chen Z., Cheng S., Xu K. Block poly(ester-urethane)s based on poly(3-hydroxybutyrate-co-4-hydroxybutyrate) and poly(3-hydroxyhexanoate-co-3- hydroxyoctanoate). Biomaterials 2009, 30:2219-2230.
21. Blow N. Small RNAs: Delivering the future. Nature 2007, 450:1117-1120.
22. Zhang H., Li Y., Wang Z., Zhang B. Establishment of xenograft mouse models to study human lung cancer by using invivo imaging system. Sheng Wu Gong Cheng Xue Bao 2009, 25:1204-1210.
23. Li Y., Zhang H., Wang Z., Zhang B. Establishment of an animal model of breast cancer based on invivo bioluminescence imaging. Tumor 2009, 29:76-80.
24. Merdan T., Callahan J., Petersen H., Kunath K., Bakowsky U., Kopecková P., et al. Pegylated Polyethylenimine-Fab' antibody fragment conjugates for targeted gene delivery to human ovarian carcinoma cells. Bioconjug Chem 2003, 14:989-996.
25. Tseng W.C., Haselton F.R., Giorgio T.D. Transfection by cationic liposomes using simultaneous single cell measurements of plasmid delivery and transgene expression. JBiol Chem 1997, 272:25641-25647.
26. Hoon Jeong J., Christensen L.V., Yockman J.W., Zhong Z., Engbersen J.F., Jong Kim W., et al. Reducible poly(amido ethylenimine) directed to enhance RNA interference. Biomaterials 2007, 28:1912-1917.
27. Xu D.M., Yao S.D., Liu Y.B., Sheng K.L., Hong J., Gong P.J., et al. Size-dependent properties of M-PEIs nanogels for gene delivery in cancer cells. Int J Pharm 2007, 338:291-296.
28. Mao S., Neu M., Germershaus O., Merkel O., Sitterberg J., Bakowsky U., et al. Influence of polyethylene glycol chain length on the physicochemical and biological properties of poly(ethylene imine)-graft-poly(ethylene glycol) block copolymer/siRNA polyplexes. Bioconjug Chem 2006, 17:1209-1218.
29. Zhang X.Q., Intra J., Salem A.K. Conjugation of polyamidoamine dendrimers on biodegradable microparticles for nonviral gene delivery. Bioconjug Chem 2007, 18:2068-2076.
30. Xiong X.B., Uludaĝ H., Lavasanifar A. Biodegradable amphiphilic poly(ethylene oxide)-block-polyesters with grafted polyamines as supramolecular nanocarriers for efficient siRNA delivery. Biomaterials 2009, 30:242-253.
31. Neu M., Sitterberg J., Bakowsky U., Kissel T. Stabilized nanocarriers for plasmids based upon cross-linked poly(ethylene imine). Biomacromolecules 2006, 7:3428-3438.
32. Chen T.H., Bae Y., Furgeson D.Y. Intelligent biosynthetic nanobiomaterials (IBNs) for hyperthermic gene delivery. Pharm Res 2008, 25:683-691.
33. Oskuee R.K., Philipp A., Dehshahri A., Wagner E., Ramezani M. The impact of carboxyalkylation of branched polyethylenimine on effectiveness in small interfering RNA delivery. JGene Med 2010, 12:729-738.
34. Park M.R., Han K.O., Han I.K., Cho M.H., Nah J.W., Choi Y.J., et al. Degradable polyethylenimine-alt-poly(ethylene glycol) copolymers as novel gene carriers. JControl Release 2005, 105:367-380.
35. Merkel O.M., Mintzer M.A., Librizzi D., Samsonova O., Dicke T., Sproat B., et al. Triazine dendrimers as nonviral vectors for invitro and invivo RNAi: the effects of peripheral groups and core structure on biological activity. Mol Pharm 2010, 7:969-983.
36. Savic R., Luo L., Eisenberg A., Maysinger D. Micellar nanocontainers distribute to defined cytoplasmic organelles. Science 2003, 300:615-618.
37. Arote R., Kim T.H., Kim Y.K., Hwang S.K., Jiang H.L., Song H.H., et al. Abiodegradable poly(ester amine) based on polycaprolactone and polyethylenimine as a gene carrier. Biomaterials 2007, 28:735-744.